Searched for: author%3A%22Bengtson%2C+M.L.%22
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document
Oyibo, P.O. (author), Jujjavarapu, S. (author), Meulah, Brice (author), Agbana, T.E. (author), Braakman, I.G. (author), van Diepen, Angela (author), Bengtson, M.L. (author), van Lieshout, Lisette (author), Andi, Wellington Oyibo (author), Vdovin, Gleb (author), Diehl, J.C. (author)
For many parasitic diseases, the microscopic examination of clinical samples such as urine and stool still serves as the diagnostic reference standard, primarily because microscopes are accessible and cost-effective. However, conventional microscopy is laborious, requires highly skilled personnel, and is highly subjective. Requirements for...
journal article 2022
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Bengtson, M.L. (author), Bharadwaj, M. (author), Franch, O. (author), van der Torre, J. (author), Meerdink, V.E.E. (author), Schallig, Henk (author), Dekker, C. (author)
Nucleic-acid detection is crucial for basic research as well as for applications in medicine such as diagnostics. In resource-limited settings, however, most DNA-detection diagnostic schemes are inapplicable since they rely on expensive machinery, electricity, and trained personnel. Here, we present an isothermal DNA detection scheme for the...
journal article 2022
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Bengtson, M.L. (author), Onasanya, A.A. (author), Oyibo, P.O. (author), Meulah, Brice (author), Samenjo, K.T. (author), Braakman, I.G. (author), Andi, Wellington Oyibo (author), Diehl, J.C. (author)
Schistosomiasis is a neglected tropical disease thatis predominantly diagnosed by conventional microscopy in Sub-Saharan Africa. However, effective diagnosis by conventional microscopy is limited by multiple technical and logistic barriers.Alternative diagnostic techniques are needed. The Schistoscope is a digital optical device that has been...
conference paper 2022
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Meulah, Brice (author), Oyibo, P.O. (author), Bengtson, M.L. (author), Agbana, T.E. (author), Laclong Lontchi, Roméo Aimé (author), Adegnika, Ayola Akim (author), Andi, Wellington Oyibo (author), Hokke, C.H. (author), Diehl, J.C. (author), van Lieshout, Lisette (author)
Conventional microscopy is the standard procedure for the diagnosis of schistosomiasis, despite its limited sensitivity, reliance on skilled personnel, and the fact that it is error prone. Here, we report the performance of the innovative (semi-)automated Schistoscope 5.0 for optical digital detection and quantification of Schistosoma...
journal article 2022
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Bengtson, M.L. (author)
The aim of this thesis was to develop a DNA-detection scheme for a point-of-care diagnostic test for Neglected Tropical Diseases (NTDs) for use within resource-limited settings. The scientific innovation is to develop an adaptable DNA-detection scheme, using CRISPR-dCas9 (catalytically inactive Cas9), that can detect the DNA of any pathogen in...
doctoral thesis 2021
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Onasanya, A.A. (author), Bengtson, M.L. (author), Oladepo, Oladimeji (author), van Engelen, J.M.L. (author), Diehl, J.C. (author)
The control and elimination of schistosomiasis have over the last two decades involved several strategies, with the current strategy by the World Health Organization (WHO)<br/>focusing mainly on treatment with praziquantel during mass drug administration (MDA). However, the disease context is complex with an interplay of social, economic,...
journal article 2021
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Bharadwaj, M. (author), Bengtson, M.L. (author), Golverdingen, Mirte (author), Waling, Loulotte (author), Dekker, C. (author)
Inadequate and nonintegrated diagnostics are the Achilles' heel of global efforts to monitor, control, and eradicate neglected tropical diseases (NTDs). While treatment is often available, NTDs are endemic among marginalized populations, due to the unavailability or inadequacy of diagnostic tests that cause empirical misdiagnoses. The need of...
review 2021
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Bengtson, M.L. (author), Bharadwaj, M. (author), ten Bosch, A.P. (author), Nyakundi, Hellen (author), Matoke-Muhia, Damaris (author), Dekker, C. (author), Diehl, J.C. (author)
The rapid growth of point-of-care (POC) diagnostic tests necessitates a clear vision of when, where, and why a new POC diagnostic test needs to be developed and how it can be used in a way that matches a local health care context. Here, we present an innovative approach toward developing a concept target product profile (CTPP), which is a new...
journal article 2020
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Yang, W.W.W. (author), Restrepo Perez, L. (author), Bengtson, M.L. (author), Heerema, S.J. (author), Birnie, A.T.F. (author), van der Torre, J. (author), Dekker, C. (author)
Solid-state nanopores have emerged as promising platforms for biosensing including diagnostics for disease detection. Here we show nanopore experiments that detect CRISPR-dCas9, a sequence-specific RNA-guided protein system that specifically binds to a target DNA sequence. While CRISPR-Cas9 is acclaimed for its gene editing potential, the...
journal article 2018
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