Searched for: author%3A%22Bomer%2C+N.%22
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Hagenbeek, Fiona A. (author), Bomer, N. (author), van Hilten, J. A. (author), Fu, J. (author), van der Heijden, A. A.W.A. (author), van der Spek, A. (author), Boersma, E. (author), van den Akker, E.B. (author), Reinders, M.J.T. (author)
Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November...
journal article 2019
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Bomer, N. (author), Den Hollander, W.T.H.F. (author), Ramos, Y.F.M. (author), Bos, S.D. (author), Van der Breggen, R. (author), Lakenberg, N. (author), Pepers, B.A. (author), Van Eeden, A.E. (author), Darvishan, A. (author), Tobi, E.W. (author), Duijnisveld, B.J. (author), Van den Akker, E.B. (author), Heijmans, B.T. (author), Van Roon-Mom, W.M.C. (author), Verbeek, F.J. (author), Osch, G.J.V.M. (author), Nelissen, R.G.H.H. (author), Slagboom, P.E. (author), Meulenbelt, I. (author)
Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG...
journal article 2015