Searched for: author%3A%22Bouland%2C+G.A.%22
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Slieker, Roderick C. (author), Münch, Magnus (author), Donnelly, Louise A. (author), Bouland, G.A. (author), Dragan, Iulian (author), Kuznetsov, Dmitry (author), Elders, Petra J.M. (author), Rutter, Guy A. (author), Ibberson, Mark (author)
Aims/hypothesis: People with type 2 diabetes are heterogeneous in their disease trajectory, with some progressing more quickly to insulin initiation than others. Although classical biomarkers such as age, HbA<sub>1c</sub> and diabetes duration are associated with glycaemic progression, it is unclear how well such variables predict insulin...
journal article 2024
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Zhang, M. (author), Bouland, G.A. (author), Holstege, H. (author), Reinders, M.J.T. (author)
Background and Objectives - With age, somatic mutations accumulated in human brain cells can lead to various neurologic disorders and brain tumors. Because the incidence rate of Alzheimer disease (AD) increases exponentially with age, investigating the association between AD and the accumulation of somatic mutation can help understand the...
journal article 2023
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Bouland, G.A. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)
With the number of cells measured in single-cell RNA sequencing (scRNA-seq) datasets increasing exponentially and concurrent increased sparsity due to more zero counts being measured for many genes, we demonstrate here that downstream analyses on binary-based gene expression give similar results as count-based analyses. Moreover, a binary...
journal article 2023
document
Bouland, G.A. (author), Mahfouz, A.M.E.T.A. (author), Reinders, M.J.T. (author)
Single-cell RNA sequencing data is characterized by a large number of zero counts, yet there is growing evidence that these zeros reflect biological variation rather than technical artifacts. We propose to use binarized expression profiles to identify the effects of biological variation in single-cell RNA sequencing data. Using 16 publicly...
journal article 2021
Searched for: author%3A%22Bouland%2C+G.A.%22
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