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Mahler, M.S. (author), Malone Portu, L.M. (author), van den Berg, D.F. (author), Smith, Leah M. (author), Brouns, S.J.J. (author), Fineran, Peter C. (author)Serratia sp. ATCC 39006 is a Gram-negative bacterium that has been used to study the function of phage defences, such as CRISPR-Cas, and phage counter-defence mechanisms. To expand our phage collection to study the phage-host interaction with Serratia sp. ATCC 39006, we isolated the T4-like myovirus LC53 in Ĺtepoti Dunedin, Aotearoa New...journal article 2023
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Mahler, M.S. (author), Martins Costa, A.R. (author), van Beljouw, S.P.B. (author), Fineran, Peter C. (author), Brouns, S.J.J. (author)In recent years, bacteriophage research has been boosted by a rising interest in using phage therapy to treat antibiotic-resistant bacterial infections. In addition, there is a desire to use phages and their unique proteins for specific biocontrol applications and diagnostics. However, the ability to manipulate phage genomes to understand and...review 2023
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Jackson, Simon A. (author), McKenzie, R. (author), Fagerlund, Robert D. (author), Kieper, S.N. (author), Fineran, Peter C. (author), Brouns, S.J.J. (author)Bacteria and archaea are engaged in a constant arms race to defend against the ever-present threats of viruses and invasion by mobile genetic elements. The most flexible weapons in the prokaryotic defense arsenal are the CRISPR-Cas adaptive immune systems. These systems are capable of selective identification and neutralization of foreign DNA...journal article 2017