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de Jong, S.I. (author), van den Broek, M.A. (author), Merkel, Alexander Y. (author), de la Torre Cortes, Pilar (author), Kalamorz, Falk (author), Cook, Gregory M. (author), van Loosdrecht, Mark C.M. (author), McMillan, D.G.G. (author)
The aerobic thermoalkaliphile Caldalkalibacillus thermarum strain TA2.A1 is a member of a separate order of alkaliphilic bacteria closely related to the Bacillales order. Efforts to relate the genomic information of this evolutionary ancient organism to environmental adaptation have been thwarted by the inability to construct a complete...
journal article 2020
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Hards, Kiel (author), McMillan, D.G.G. (author), Schurig-Briccio, Lici A. (author), Gennis, Robert B. (author), Lill, Holger (author), Bald, Dirk (author), Cook, Gregory M. (author)
Bedaquiline (BDQ), an inhibitor of the mycobacterial F<sub>1</sub>F<sub>o</sub>-ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent new target space. Several studies have recently suggested that BDQ ultimately causes mycobacterial cell death through a phenomenon known as...
journal article 2018