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Porphyrinic metal-organic frameworks as molybdenum adsorbents for the ⁹⁹Mo/^99mTc generator

Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

Two porphyrinic metal-organic frameworks (PCN-222 and PCN-224) were prepared and their potential as molybdenum adsorbents for the ⁹⁹Mo/^99mTc generator was explored. The molybdenum adsorption properties of the two adsorbents, including adsorption kinetics and equilibrium isotherms, were evaluated at different molybdenum...

journal article 2023

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A cerium-based metal-organic framework as adsorbent for the ⁹⁹Mo/^99mTc generator

Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the ⁹⁹Mo/^99mTc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was...

journal article 2022

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Effects of High Gamma Doses on the Structural Stability of Metal-Organic Frameworks

Ma, C. (author), Liu, H. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

Four different MOFs were exposed to γrays by a cobalt-60 source reaching a maximum dose of 5 MGy. The results showed that the MIL-100 (Cr) and MIL-100 (Fe) did not exhibit obvious structural damage, suggesting their excellent radiation stability. MIL-101 (Cr) showed good radiation stability up to 4 MGy, but its structure started degrading...

journal article 2022

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Adsorption of molybdenum on Zr-based MOFs for potential application in the ⁹⁹Mo/^99mTc generator

Ma, C. (author), Vasileiadis, A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

The potential of the metal–organic framework UiO-66 and its functionalized derivatives for their utilization in the ⁹⁹Mo/^99mTc generator was assessed. Molybdenum adsorption experiments, structure characterization, molecular simulations and column experiments with molybdenum-99 were carried out. The results showed that...

journal article 2021

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Solid phase extraction-based separation of the nuclear isomers ^177mLu and ¹⁷⁷Lu

Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

A solid phase extraction based ^177mLu-¹⁷⁷Lu separation method has been investigated for its feasibility to be used in the radionuclide generator. The use of 2,2′,2”-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid, (DOTAGA-anhydride) allowed grafting of DOTA (1,4,7,10...

journal article 2020

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Modelling of the ^177mLu/¹⁷⁷Lu radionuclide generator

Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

In order to determine the potential of ^177mLu/¹⁷⁷Lu radionuclide generator in ¹⁷⁷Lu production it is important to establish the technical needs that can lead to a clinically acceptable ¹⁷⁷Lu product quality. In this work, a model that includes all the processes and the parameters affecting the...

journal article 2020

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Radionuclide generator-based production of therapeutic 177Lu from its long-lived isomer 177mLu

Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

Background In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction. Methods The 177mLu cations were complexed with DOTA &...

journal article 2019

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Isolated fe sites in metal organic frameworks catalyze the direct conversion of methane to methanol

Osadchii, D. (author), Olivos Suarez, A.I. (author), Szécsényi, A. (author), Li, G. (author), Nasalevich, M. (author), Dugulan, A.I. (author), Serra Crespo, P. (author), Hensen, Emiel J.M. (author), Veber, Sergey L. (author), Fedin, Matvey V. (author), Sankar, Gopinathan (author), Pidko, E.A. (author), Gascon, Jorge (author)

Hybrid materials bearing organic and inorganic motifs have been extensively discussed as playgrounds for the implementation of atomically resolved inorganic sites within a confined environment, with an exciting similarity to enzymes. Here, we present the successful design of a site-isolated mixed-metal metal organic framework (MOF) that...

journal article 2018

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Optimization of the signal-to-background ratio in prompt gamma imaging using energy- and shifting time-of-flight discrimination: experiments with a scanning parallel-slit collimator

Cambraia Lopes Ferreira da Silva, P. (author), Serra Crespo, P. (author), Huizenga, J. (author), Schaart, D.R. (author)

Much attention is currently being paid to imaging prompt gamma (PG) rays for in vivo proton range monitoring in proton therapy. PG imaging using a collimator is affected by neutron-related background. We study the effectiveness of background reduction experimentally, using a scanning parallel-slit PG collimator as a simplified model of a...

journal article 2018

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Separation of nuclear isomers for cancer therapeutic radionuclides based on nuclear decay after-effects

Bhardwaj, R. (author), van der Meer, A.J.G.M. (author), Das, S.K. (author), de Bruin, M (author), Gascon, Jorge (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)

177Lu has sprung as a promising radionuclide for targeted therapy. The low soft tissue penetration of its β− emission results in very efficient energy deposition in small-size tumours. Because of this, 177Lu is used in the treatment of neuroendocrine tumours and is also clinically approved for prostate cancer therapy. In this work, we report a...

journal article 2017

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Nanocarrier-Mediated Photochemotherapy and Photoradiotherapy

Denkova, A.G. (author), de Kruijff, R.M. (author), Serra Crespo, P. (author)

Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treatments. However, most preclinical studies show that complete elimination of tumors is rarely...

journal article 2017

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Analysis of Sedimentation in the Guayas River at Guayaquil, Ecuador (PPT)

Mosselman, E. (author), Barrera Crespo, P. (author), Becker, A (author), Ottevanger, W. (author), Nabi, M. (author), Giardino, A (author), de Keizer, O (author), Arias Hidalgo, M.E. (author), Sanchez, D. (author), Pazmiño Nelson, N. (author)

The Equatorian Daule and Babahoyo rivers combine into the tidal Guayas River with the largest estuary on the Pacific coast of South America. The city of Guayaquil, located along the Guayas, is the main port of Ecuador but at the same time the planet’s fourth most vulnerable city for future flooding due to climate change, after Guangzhou, Mumbai...

other 2017

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Analysis of Sedimentation in the Guayas River at Guayaquil, Ecuador

Barrera Crespo, P. (author), Becker, A (author), Ottevanger, W. (author), Nabi, M. (author), Giardino, A (author), de Keizer, O (author), Arias Hidalgo, M.E. (author), Sanchez, D. (author), Mosselman, E. (author), Pazmiño Nelson, N. (author)

The Equatorian Daule and Babahoyo rivers combine into the tidal Guayas River with the largest estuary on the Pacific coast of South America. The city of Guayaquil, located along the Guayas, is the main port of Ecuador but at the same time the planet’s fourth most vulnerable city for future flooding due to climate change, after Guangzhou, Mumbai...

abstract 2017

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Temperature-Dependent Supramolecular Isomerism of Lutetium-Aminoterephthalate Metal-Organic Frameworks: Synthesis, Crystallography, and Physical Properties

Dikhtiarenko, A. (author), Serra Crespo, P. (author), Castellanos Ortega, S. (author), Pustovarenko, Alexey (author), Mendoza-Merono, Rafael (author), García-Granda, Santiago (author), Gascon, Jorge (author)

Three supramolecular isomers of lutetium metal-organic framework, {Lu₂(H₂O)₄(ATA)₃·4H₂O}_n (Lu-ATA@RT), {Lu₂(H₂O)₂(C₃H₇NO)₂(ATA)₃}_n (Lu-ATA@100), and {Lu₂(C₃H<sub>7</sub...

journal article 2016

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Evidence for a chemical clock in oscillatory formation of UiO-66

Goesten, M.G. (author), de Lange, M.F. (author), Olivos Suarez, A.I. (author), Bavykina, A.V. (author), Serra Crespo, P. (author), Krywka, C. (author), Bickelhaupt, F. M. (author), Kapteijn, F. (author), Gascon, Jorge (author)

Chemical clocks are often used as exciting classroom experiments, where an induction time is followed by rapidly changing colours that expose oscillating concentration patterns. This type of reaction belongs to a class of nonlinear chemical kinetics also linked to chaos, wave propagation and Turing patterns. Despite its vastness in occurrence...

journal article 2016

document

The impact of post-synthetic linker functionalization of MOFS on methane storage: the role of defects

Szilagyi, Petra (author), Serra Crespo, P. (author), Gascon, Jorge (author), Geerlings, J.J.C. (author), Dam, B. (author)

journal article 2016

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First in situ TOF-PET study using digital photon counters for proton range verification

Cambraia Lopes, P (author), Bauer, J. (author), Salomon, A. (author), Rinaldi, I (author), Tabacchini, V. (author), Tessonnier, T. (author), Crespo, P (author), Parodi, K (author), Schaart, D.R. (author)

Positron emission tomography (PET) is the imaging modality most extensively tested for treatment monitoring in particle therapy. Optimal use of PET in proton therapy requires in situ acquisition of the relatively strong ¹⁵O signal due to its relatively short half-life (∼2 min) and high oxygen content in biological tissues, enabling...

journal article 2016

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Time-resolved imaging of prompt-gamma rays for proton range verification using a knife-edge slit camera based on digital photon counters

Cambraia Lopes, P. (author), Clementel, E. (author), Crespo, P. (author), Henrotin, S. (author), Huizenga, J. (author), Janssens, G. (author), Parodi, K. (author), Prieels, D. (author), Roellinghoff, F. (author), Smeets, J. (author), Stichelbaut, F. (author), Schaart, D.R. (author)

Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as a potential tool for real-time proton range monitoring. A major challenge in collimated PG imaging is the suppression of...

journal article 2015

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Aminoterephthalate Metal-Organic Frameworks: Synthesis, Characterization and Applications

Serra Crespo, P. (author)

doctoral thesis 2014

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Molecular simulation of gas adsorption and diffusion in a breathing MOF using a rigid force field

García-Pérez, E. (author), Serra-Crespo, P. (author), Hamad, S. (author), Kapteijn, F. (author), Gascon, J. (author)

Simulation of gas adsorption in flexible porous materials is still limited by the slow progress in the development of flexible force fields. Moreover, the high computational cost of such flexible force fields may be a drawback even when they are fully developed. In this work, molecular simulations of gas adsorption and diffusion of carbon...

journal article 2014