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van Oossanen, R. (author), Maier, A. (author), Godart, Jérémy (author), Pignol, Jean Philippe (author), Denkova, A.G. (author), van Rhoon, Gerard C. (author), Djanashvili, K. (author)Objective: To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field. Methods: Hybrid nanoparticles consisting of palladium-core and iron oxide shell of increasing thickness,...journal article 2024
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Androulakis, Ioannis (author), Ferrero, Riccardo (author), van Oossanen, R. (author), Manzin, Alessandra (author), Denkova, A.G. (author), Djanashvili, K. (author), Nadar, R.A. (author), van Rhoon, G.C. (author)While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose–effect relationship is still not well quantified, and it is still unclear how it can be optimally combined with other treatment modalities. Additionally, it is speculated that different methods of applying...journal article 2023
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Peters, J.A. (author), Djanashvili, K. (author)In this review, the chemical mechanisms behind the interactions between boronic acids and N-acetylneuraminic acids, which have been widely utilized in biomedicine in recent decades, will be examined. It will also be highlighted that the affinity of boronic acids for N-acetylneuraminic acids is dependent on pH and is complementary to their...review 2023
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Lacerda, Sara (author), Zhang, W. (author), T. M. De Rosales, Rafael (author), Da Silva, Isidro (author), Sobilo, Julien (author), Lerondel, Stéphanie (author), Tóth, Éva (author), Djanashvili, K. (author)Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/colloidal stability and desired biological properties, the...journal article 2022
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Gupta, Aastha (author), Sood, Ankur (author), Fuhrer, Erwin (author), Djanashvili, K. (author), Agrawal, Garima (author)Designing novel systems for efficient cancer treatment and improving the quality of life for patients is a prime requirement in the healthcare sector. In this regard, theranostics have recently emerged as a unique platform, which combines the benefits of both diagnosis and therapeutics delivery. Theranostics have the desired contrast agent...review 2022
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van Oossanen, R. (author), Godart, Jeremy (author), Brown, J.M.C. (author), Maier, A. (author), Pignol, Jean-Philippe (author), Denkova, A.G. (author), Djanashvili, K. (author), van Rhoon, G.C. (author)Background: Treatment of early-stage breast cancer currently includes surgical removal of the tumor and (partial) breast irradiation of the tumor site performed at fractionated dose. Although highly effective, this treatment is exhaustive for both patient and clinic. In this study, the theoretical potential of an alternative treatment combining...journal article 2022
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Maier, A. (author), van Oossanen, R. (author), van Rhoon, G.C. (author), Pignol, J.P.M. (author), Dugulan, A.I. (author), Denkova, A.G. (author), Djanashvili, K. (author)Heterostructured magnetic nanoparticles show great potential for numerous applications in biomedicine due to their ability to express multiple functionalities in a single structure. Magnetic properties are generally determined by the morphological characteristics of nanoparticles, such as the size/shape, and composition of the nanocrystals....journal article 2022
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Martinelli, J. (author), Tei, Lorenzo (author), Geninatti Crich, Simonetta (author), Alberti, Diego (author), Djanashvili, K. (author)It is known that phenylboronic acid (PBA) can target tumor tissues by binding to sialic acid, a substrate overexpressed by cancer cells. This capability has previously been explored in the design of targeting diagnostic probes such as Gd- and 68Ga-DOTA-EN-PBA, two contrast agents for magnetic resonance imaging (MRI) and positron emission...journal article 2021
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López-Pérez, Lidia (author), López-Martínez, Marco Antonio (author), Djanashvili, K. (author), Góra-Marek, Kinga (author), Tarach, Karolina A. (author), Borges, María Emma (author), Melián-Cabrera, Ignacio (author)Mesoporous materials are of vital importance for use in separation, adsorption, and catalysis. The first step in their preparation consists of synthesizing an organic-inorganic hybrid in which a structuring directing agent (SDA, normally a surfactant) is used to provide the desired porosity. The most common method to eliminate the SDA, and...journal article 2020
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Zhang, W. (author), Liu, H. (author), van Schie, M.M.C.H. (author), Hagedoorn, P.L. (author), Alcalde, Miguel (author), Denkova, A.G. (author), Djanashvili, K. (author), Hollmann, F. (author)It is well-known that energy-rich radiation induces water splitting, eventually yielding hydrogen peroxide. Synthetic applications, however, are scarce and to the best of our knowledge, the combination of radioactivity with enzyme-catalysis has not been considered yet. Peroxygenases utilize H2O2 as an oxidant to promote highly selective...journal article 2020
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Peters, J.A. (author), Djanashvili, K. (author), Geraldes, Carlos F.G.C. (author), Platas-Iglesias, Carlos (author)In the periodical system, the lanthanides (the 15 elements in the periodic table between barium and hafnium) are unique in the sense that their trivalent cations have their valence electrons hidden behind the 5s and 5p electrons. They show a gradual decrease in ionic radius with increasing atomic number (also known as the lanthanide...review 2020
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Martinelli, J. (author), Jiménez-Juárez, R. (author), Alberti, Diego (author), Geninatti Crich, Simonetta (author), Djanashvili, K. (author)Paramagnetic macrocycles functionalized with phenylboronic moieties have proven to be interesting for MRI applications based on their ability to recognize cancer cells and generate local contrast. However, full use of the potential of this class of compounds is hampered by laborious and inefficient synthetic and, especially, purification...journal article 2020
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Fauzia, R.P. (author), Denkova, A.G. (author), Djanashvili, K. (author)Radiation therapy has made tremendous progress in oncology over the last decades due to advances in engineering and physical sciences in combination with better biochemical, genetic and molecular understanding of this disease. Local delivery of optimal radiation dose to a tumor, while sparing healthy surrounding tissues, remains a great...journal article 2019
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Tsoukalas, Charalambos (author), Geninatti-Crich, Simonetta (author), Gaitanis, Anastasios (author), Tsotakos, Theodoros (author), Paravatou-Petsotas, Maria (author), Aime, Silvio (author), Jiménez-Juárez, R. (author), Anagnostopoulos, Constantinos D. (author), Djanashvili, K. (author), Bouziotis, Penelope (author)Purpose: The aim of this study was to demonstrate the potential of Ga-68-labeled macrocycle (DOTA-en-pba) conjugated with phenylboronic vector for tumor recognition by positron emission tomography (PET), based on targeting of the overexpressed sialic acid (Sia). Procedures: The imaging reporter DOTA-en-pba was synthesized and labeled with Ga...journal article 2018
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Mayer, F. (author), Tiruvadi Krishnan, S. (author), Schuhle, DT (author), Eliseeva, Svetlana V. (author), Petoud, Stephane (author), Toth, Eva (author), Djanashvili, K. (author)Self-aggregating calix[4]arenes carrying four DOTA ligands on the upper rim for stable complexation of paramagnetic GdIII-ions have already been proposed as MRI probes. In this work, we investigate the luminescence properties of TbIII-DOTA-calix[4]arene-4OPr containing four propyl-groups and compare them with those of the analog substituted with...journal article 2018
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ten Dam, J. (author), Ramanathan, A. (author), Djanashvili, K. (author), Kapteijn, F. (author), Hanefeld, U. (author)The synthesis of a series of bifunctional catalysts (1 wt% Pt/W-TUD-1 (Technische Universiteit Delft-1) and 1 wt% Pt/WO<sub>3</sub>/TUD-1) with different tungsten loadings (5-30 wt% WO<sub>3</sub>) is described. They were characterized using ICP-OES, INAA, N<sub>2</sub> physisorption, XRD and TEM. Their catalytic performance (activity and...journal article 2017
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Zhang, W. (author), Martinelli, J. (author), Peters, J.A. (author), van Hengst, Jacob M.A. (author), Bouwmeester, Hans (author), Kramer, Evelien (author), Bonnet, Celia S. (author), Szeremeta, Frederic (author), Toth, Eva (author), Djanashvili, K. (author)Surface PEGylation of nanoparticles designed for biomedical applications is a common and straightforward way to stabilize the materials for in vivo administration and to increase their circulation time. This strategy becomes less trivial when MRI active porous nanomaterials are concerned as their function relies on water/proton-exchange between...journal article 2017
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Zhang, W. (author), Arends, I.W.C.E. (author), Djanashvili, K. (author)Lanthanide oxysulfates have the ability to store and release large volumes of oxygen under oxidizing/reducing conditions, rendering them interesting as automotive catalysts. Herein we demonstrate a remarkable improvement of both processes by utilization of nanoparticles compared to the bulk materials. A further improvement of the catalytic...journal article 2016
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Zhang, W. (author), Martinelli, J. (author), Mayer, F. (author), Bonnet, C.S. (author), Szeremeta, F. (author), Djanashvili, K. (author)Among the procedures to prepare lanthanide-containing nanoparticles a gap exists in the range between 5 and 40 nm. The miniemulsion technique presented here is intended to fill this discontinuity and offers a facile method that can be applied for the preparation of nanoparticles for various applications, e.g. medical imaging, optics and...journal article 2015
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Cui, X. (author), Green, M.A. (author), Blower, P.J. (author), Zhou, D. (author), Yan, Y. (author), Zhang, W. (author), Djanashvili, K. (author), Mathe, D. (author), Veres, D.S. (author), Szigeti, K. (author)Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)3-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with 18F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate...journal article 2015
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