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Pries, A.R. (author), Cornelissen, A.J.M. (author), Sloot, A.A. (author), Hinkeldey, M. (author), Dreher, M.R. (author), Höpfner, M. (author), Dewhirst, M.W. (author), Secomb, T.W. (author)
Relative to normal tissues, tumor microcirculation exhibits high structural and functional heterogeneity leading to hypoxic regions and impairing treatment efficacy. Here, computational simulations of blood vessel structural adaptation are used to explore the hypothesis that abnormal adaptive responses to local hemodynamic and metabolic stimuli...
journal article 2009