Searched for: author%3A%22Eppink%2C+Michel+H.M.%22
(1 - 6 of 6)
document
Neves Sao Pedro, M. (author), Isaksson, Madelène (author), Gomis-Fons, Joaquín (author), Eppink, Michel H.M. (author), Nilsson, Bernt (author), Ottens, M. (author)
The implementation of continuous processing in the biopharmaceutical industry is hindered by the scarcity of process analytical technologies (PAT). To monitor and control a continuous process, PAT tools will be crucial to measure real-time product quality attributes such as protein aggregation. Miniaturizing these analytical techniques can...
journal article 2023
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Neves Sao Pedro, M. (author), Eppink, Michel H.M. (author), Ottens, M. (author)
The lack of process analytical technologies able to provide real-time information and process control over a biopharmaceutical process has long impaired the transition to continuous biomanufacturing. For the monoclonal antibody (mAb) production, aggregate formation is a major critical quality attribute (CQA) with several known process...
journal article 2023
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Neves Sao Pedro, M. (author), Silva dos Santos, M. (author), Eppink, Michel H.M. (author), Ottens, M. (author)
A major challenge in the transition to continuous biomanufacturing is the lack of process analytical technology (PAT) tools which are able to collect real-time information on the process and elicit a response to facilitate control. One of the critical quality attributes (CQAs) of interest during monoclonal antibodies production is aggregate...
journal article 2022
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Neves Sao Pedro, M. (author), Klijn, M.E. (author), Eppink, Michel H.M. (author), Ottens, M. (author)
The transition to continuous biomanufacturing is considered the next step to reduce costs and improve process robustness in the biopharmaceutical industry, while also improving productivity and product quality. The platform production process for monoclonal antibodies (mAbs) is eligible for continuous processing to lower manufacturing costs...
review 2021
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Pirrung, S.M. (author), Berends, Carmen (author), Backx, Antoon H. (author), van Beckhoven, Ruud F.W.C. (author), Eppink, Michel H.M. (author), Ottens, M. (author)
Finding the best purification process is a challenging task. Recently, mechanistic models that can accelerate the development of chromatographic unit operations, the most important purification units, became widely available. In previous work, several chromatographic models have been linked together to simulate and optimize integrated...
journal article 2019
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Pirrung, S.M. (author), Parruca Da Cruz, D.E. (author), Hanke, A.T. (author), Berends, C. (author), Van Beckhoven, Ruud F.W.C. (author), Eppink, Michel H.M. (author), Ottens, M. (author)
The application of mechanistic models for chromatography requires accurate model parameters. Especially for complex feedstocks such as a clarified cell harvest, this can still be an obstacle limiting the use of mechanistic models. Another commonly encountered obstacle is a limited amount of sample material and time to determine all needed...
journal article 2018
Searched for: author%3A%22Eppink%2C+Michel+H.M.%22
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