Searched for: author%3A%22Gijsen%2C+F.J.H.%22
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Jansen, Imke (author), Cahalane, Rachel (author), Hengst, Ranmadusha (author), Akyildiz, A.C. (author), Farrell, Eric (author), Gijsen, F.J.H. (author), Aikawa, Elena (author), van der Heiden, Kim (author), Wissing, Tamar (author)
The rupture of an atherosclerotic plaque cap overlying a lipid pool and/or necrotic core can lead to thrombotic cardiovascular events. In essence, the rupture of the plaque cap is a mechanical event, which occurs when the local stress exceeds the local tissue strength. However, due to inter- and intra-cap heterogeneity, the resulting ultimate...
review 2024
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Cruts, Janneke M. H. (author), Giezen, Jo-Anne (author), van Gaalen, Kim (author), Beurskens, Robert (author), Ridwan, Yanto (author), Dijkshoorn, Marcel L. (author), Boodt, Nikki (author), Gijsen, F.J.H. (author), Cahalane, R.M.E. (author)
Background<br/>Clot composition, contraction, and mechanical properties are likely determinants of endovascular thrombectomy success. A pre-interventional estimation of these properties is hypothesized to aid in selecting the most suitable treatment for different types of thrombi. Here we determined the association between the aforementioned...
journal article 2023
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Cahalane, R.M.E. (author), de Vries, J.J. (author), de Maat, Moniek P.M. (author), van Gaalen, Kim (author), van Beusekom, Heleen M. (author), van der Lugt, Aad (author), Fereidoonnezhad, B.F. (author), Akyildiz, A.C. (author), Gijsen, F.J.H. (author)
Endovascular thrombectomy procedures are significantly influenced by the mechanical response of thrombi to the multi-axial loading imposed during retrieval. Compression tests are commonly used to determine compressive ex vivo thrombus and clot analogue stiffness. However, there is a shortage of data in tension. This study compares the tensile...
journal article 2023
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Cahalane, R.M.E. (author), Akyildiz, A.C. (author), Kavousi, Maryam (author), Vernooij, Meike W. (author), Ikram, M. Kamran (author), Gijsen, F.J.H. (author), Bos, Daniel (author)
Background The purpose of this study was to validate a technique for measuring mean calcium density and to determine associations of cardiovascular risk factors with carotid calcium density. Methods and Results We performed a cross-sectional study in a random sample of 100 stroke-free participants from the population-based Rotterdam Study....
journal article 2023
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Jansen, Imke (author), Crielaard, Hanneke (author), Wissing, Tamar (author), Bouten, Carlijn (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author), Farrell, Eric (author), van der Heiden, Kim (author)
Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has been suggested, through computational models, that the presence of microcalcifications in the atherosclerotic cap can increase the risk of cap rupture. However, the experimental confirmation of this hypothesis is still lacking. In this study,...
journal article 2023
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Migliavacca, Francesco (author), Luraghi, G. (author), Akyildiz, A.C. (author), Gijsen, F.J.H. (author)
contribution to periodical 2022
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Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author)
The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two...
journal article 2022
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Wissing, T. B. (author), Van der Heiden, K. (author), Serra, S.M. (author), Smits, A. I.P.M. (author), Bouten, C. V.C. (author), Gijsen, F.J.H. (author)
A significant amount of vascular thrombotic events are associated with rupture of the fibrous cap that overlie atherosclerotic plaques. Cap rupture is however difficult to predict due to the heterogenous composition of the plaque, unknown material properties, and the stochastic nature of the event. Here, we aim to create tissue engineered...
journal article 2022
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Luraghi, G. (author), Bridio, Sara (author), Lissoni, Vittorio (author), Dubini, Gabriele (author), Dwivedi, Anushree (author), McCarthy, Ray (author), Fereidoonnezhad, B.F. (author), McGarry, Patrick (author), Gijsen, F.J.H. (author)
Mechanical thrombectomy (MT) treatment of acute ischemic stroke (AIS) patients typically involves use of stent retrievers or aspiration catheters alone or in combination. For in silico trials of AIS patients, it is crucial to incorporate the possibility of thrombus fragmentation during the intervention. This study focuses on two aspects of...
journal article 2022
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Guvenir Torun, Su (author), Torun, Hakki M. (author), Hansen, Hendrik H.G. (author), de Korte, Chris L. (author), van der Steen, Antonius F.W. (author), Gijsen, F.J.H. (author), Akyildiz, A.C. (author)
Objective: Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it is correlated with high plaque stresses. Hence, analyzing stress patterns is essential for plaque specific rupture risk assessment. However, the critical information of the multicomponent material properties of atherosclerotic carotid...
journal article 2022
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Crielaard, Hanneke (author), Guvenir Torun, Su (author), Wissing, Tamar B. (author), de Miguel Muñoz, Pablo (author), Kremers, Gert Jan (author), Gijsen, F.J.H. (author), Van Der Heiden, Kim (author), Akyildiz, A.C. (author)
The rupture of atherosclerotic plaques in coronary and carotid arteries is the primary cause of fatal cardiovascular events. However, the rupture mechanics of the heterogeneous, highly collagenous plaque tissue, and how this is related to the tissue's fibrous structure, are not known yet. Existing pipelines to study plaque mechanics are...
journal article 2022
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Gijsen, F.J.H. (author), Vis, Bas (author), Barrett, Hilary E. (author), Zadpoor, A.A. (author), Verhagen, Hence J. (author), Bos, Daniel (author), van der Steen, A.F.W. (author), Akyildiz, A.C. (author)
Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent in carotid plaques, but their role in plaque rupture remains poorly understood. This work studied the morphometric features of calcifications in carotid plaques and their effect on the stress...
journal article 2021
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McElroy, Michael (author), Kim, Yongcheol (author), Niccoli, Giampaolo (author), Vergallo, Rocco (author), Langford-Smith, Alexander (author), Crea, Filippo (author), Gijsen, F.J.H. (author), Johnson, Thomas (author), Keshmiri, Amir (author)
Endothelial erosion of atherosclerotic plaques is the underlying cause of approximately 30% of acute coronary syndromes (ACS). As the vascular endothelium is profoundly affected by the haemodynamic environment to which it is exposed, we employed computational fluid dynamic (CFD) analysis of the luminal geometry from 17 patients with optical...
journal article 2021
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Van der Heiden, K. (author), Barrett, H. E. (author), van Gaalen, K.C. (author), Krenning, B. J. (author), Beekman, F.J. (author), Verhagen, H. J.M. (author), Norenberg, J. P. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Background: Calcification and inflammation are atherosclerotic plaque compositional biomarkers that have both been linked to stroke risk. The aim of this study was to evaluate their co-existing prevalence in human carotid plaques with respect to plaque phenotype to determine the value of hybrid imaging for the detection of these biomarkers....
journal article 2021
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Boodt, Nikki (author), Snouckaert Van Schauburg, Philip R.W. (author), Hund, Hajo M. (author), Fereidoonnezhad, B.F. (author), McGarry, J. Patrick (author), Akyildiz, A.C. (author), Van Es, Adriaan C.G.M. (author), Van Der Lugt, Aad (author), Gijsen, F.J.H. (author)
Background and Purpose: Mechanical properties of thromboemboli play an important role in the efficacy of endovascular thrombectomy (EVT) for acute ischemic stroke. However, very limited data on mechanical properties of human stroke thrombi are available. We aimed to mechanically characterize thrombi retrieved with EVT, and to assess the...
journal article 2021
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Barrett, Hilary E. (author), Meester, Eric J. (author), van Gaalen, Kim (author), van der Heiden, Kim (author), Krenning, Boudewijn J. (author), Beekman, F.J. (author), Verhagen, H. J. (author), de Jong, M. (author), Gijsen, F.J.H. (author)
Purpose: Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer...
journal article 2020
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Voorneveld, J.D. (author), Saaid, H. (author), Schinkel, C.V. (author), Radeljic, Nikola (author), Lippe, Boris (author), Gijsen, F.J.H. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Claessens, Tom (author), Vos, H.J. (author), Kenjeres, S. (author), Bosch, Johan G. (author)
Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for...
journal article 2020
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Saaid, Hicham (author), Voorneveld, Jason (author), Schinkel, C.V. (author), Westenberg, Jos (author), Gijsen, F.J.H. (author), Segers, Patrick (author), Verdonck, Pascal (author), de Jong, N. (author), Kenjeres, S. (author)
Left ventricular flow is intrinsically complex, three-dimensional and unsteady. Its features are susceptible to cardiovascular pathology and treatment, in particular to surgical interventions involving the valves (mitral valve replacement). To improve our understanding of intraventricular fluid mechanics and the impact of various types of...
journal article 2019
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Voorneveld, J.D. (author), Engelhard, S. (author), Vos, H.J. (author), Reijnen, M. (author), Gijsen, F.J.H. (author), Versluis, M. (author), Jebbink, E. Groot (author), de Jong, N. (author), Bosch, J. G. (author)
Treatment of abdominal aortic (AA) aneurysms and stenotic lesions may be improved by analyzing their associated blood flow patterns. Angle-independent blood flow patterns in the AA can be obtained by combining echo-particle image velocimetry (ePIV) with high frame rate contrast-enhanced ultrasonography. However, ePIV performance is affected...
journal article 2018
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Kok, Annette M. (author), Speelman, Lambert (author), Virmani, Renu (author), van der Steen, A.F.W. (author), Gijsen, F.J.H. (author), Wentzel, Jolanda J. (author)
Background: Stress calculations in atherosclerotic coronary vulnerable plaques can aid in predicting coronary cap rupture. In vivo plaque geometry and composition of coronary arteries can merely be obtained via intravascular imaging. Only optical driven imaging techniques have sufficient resolution to visualize the fibrous cap, but due to...
journal article 2016
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