Searched for: author%3A%22Godoy+Hernandez%2C+A.%22
(1 - 6 of 6)
document
Godoy Hernandez, A. (author), Asseri, Amer H. (author), Purugganan, Aiden J. (author), Jiko, Chimari (author), de Ram, C. (author), Lill, Holger (author), Pabst, Martin (author), Mitsuoka, Kaoru (author), Gerle, Christoph (author), Bald, Dirk (author), McMillan, D.G.G. (author)
Functional reintegration into lipid environments represents a major challenge for in vitro investigation of integral membrane proteins (IMPs). Here, we report a new approach, termed LMNG Auto-insertion Reintegration (LAiR), for reintegration of IMPs into lipid bilayers within minutes. The resulting proteoliposomes displayed an unprecedented...
journal article 2023
document
Godoy Hernandez, A. (author)
The rise of multi-drug resistant bacterial infections is a worldwide growing concern. Despite being one of the greatest medical advances of the 20th century, classical antibiotics are no longer effective against such organisms. Unfortunately, patients infected with drug-resistant bacteria are more likely to experience worse clinical outcomes, as...
doctoral thesis 2022
document
Godoy Hernandez, A. (author), McMillan, D.G.G. (author)
Lipids play a pivotal role in cellular respiration, providing the natural environment in which an oxidoreductase interacts with the quinone pool. To date, it is generally accepted that negatively charged lipids play a major role in the activity of quinone oxidoreductases. By changing lipid compositions when assaying a type II NADH:quinone...
journal article 2021
document
Asseri, Amer H. (author), Godoy Hernandez, A. (author), Goojani, Hojjat Ghasemi (author), Lill, Holger (author), Sakamoto, Junshi (author), McMillan, D.G.G. (author), Bald, Dirk (author)
Cardiolipin (CL) is a lipid that is found in the membranes of bacteria and the inner membranes of mitochondria. CL can increase the activity of integral membrane proteins, in particular components of respiratory pathways. We here report that CL activated detergent-solubilized cytochrome bd, a terminal oxidase from Escherichia coli. CL...
journal article 2021
document
Boes, Deborah M. (author), Godoy Hernandez, A. (author), McMillan, D.G.G. (author)
Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction. Peripheral membrane proteins are highly unique amphipathic proteins that interact with the membrane indirectly, using electrostatic or hydrophobic interactions, or directly, using...
journal article 2021
document
Godoy Hernandez, A. (author), Tate, Daniel J. (author), McMillan, D.G.G. (author)
Type-II NADH:quinone oxidoreductases (NDH-2s) are an important element of microbial pathogen electron transport chains and an attractive drug target. Despite being widely studied, its mechanism and catalysis are still poorly understood in a hydrophobic membrane environment. A recent report for the Escherichia coli NDH-2 showed NADH oxidation...
journal article 2019
Searched for: author%3A%22Godoy+Hernandez%2C+A.%22
(1 - 6 of 6)