Searched for: author%3A%22Gon%C3%A7alves%2C+Joana%22
(1 - 14 of 14)
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Gisch, Debora L. (author), Brennan, Michelle (author), Lake, Blue B. (author), Basta, Jeannine (author), Keller, Mark S. (author), P. Gonçalves, Joana (author), Migas, L.G. (author), Van de Plas, Raf (author), Lardenoije, R. (author)
There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. Comprehensive integration of gene expression with epigenetic features that define regulatory elements remains a...
journal article 2024
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Liu, Chi (author), Gonçalves, Joana (author), Quist, W.J. (author)
This paper explores the opportunities for locals’ participation as a tool for the sustainable redevelopment of vacant heritage. It focuses on the Politiebureau Groningen Centrum (The Netherlands) as a case study to apply a novel approach to engage community participation in architectural redesign. It fills the academic gap on participation in...
journal article 2023
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Tepeli, Y.I. (author), Seale, C.F. (author), P. Gonçalves, Joana (author)
Motivation<br/><br/>Anti-cancer therapies based on synthetic lethality (SL) exploit tumour vulnerabilities for treatment with reduced side effects, by targeting a gene that is jointly essential with another whose function is lost. Computational prediction is key to expedite SL screening, yet existing methods are vulnerable to prevalent selection...
journal article 2023
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Gonçalves, Joana (author), Mateus, Ricardo (author), Silvestre, José Dinis (author), Pereira Roders, A. (author)
The role of heritage buildings in pursuing a more sustainable built environment has been widely discussed in the last decades, from their importance to cohesive and inclusive communities to their contribution to resources conservation and therefore to reducing materials-related carbon emissions. Norms, policies, standards, and design-aid tools...
book chapter 2023
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Jain, Sanjay (author), Pei, Liming (author), Spraggins, Jeffrey M. (author), Angelo, Michael (author), Carson, James P. (author), Gehlenborg, Niels (author), Ginty, Fiona (author), P. Gonçalves, Joana (author), Van de Plas, Raf (author)
The Human BioMolecular Atlas Program (HuBMAP) aims to create a multi-scale spatial atlas of the healthy human body at single-cell resolution by applying advanced technologies and disseminating resources to the community. As the HuBMAP moves past its first phase, creating ontologies, protocols and pipelines, this Perspective introduces the...
journal article 2023
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Seale, C.F. (author), Tepeli, Y.I. (author), P. Gonçalves, Joana (author)
Motivation<br/>Synthetic lethality (SL) between two genes occurs when simultaneous loss of function leads to cell death. This holds great promise for developing anti-cancer therapeutics that target synthetic lethal pairs of endogenously disrupted genes. Identifying novel SL relationships through exhaustive experimental screens is challenging,...
journal article 2022
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Gonçalves, Joana (author), Mateus, Ricardo (author), Dinis Silvestre, José (author), Pereira Roders, A. (author), Bragança, Luís (author)
Purpose: This research presents the development of a Building Passport for Sustainable Conservation (BPSC) as a questionnaire with a set of 23 core indicators, for a baseline assessment of heritage buildings. The aim of this tool is to identify priorities for future interventions, by recognising the contributions of heritage buildings to...
journal article 2022
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Gonçalves, Joana (author), Mateus, Ricardo (author), Silvestre, José Dinis (author), Pereira Roders, A. (author)
The inclusion of Heritage in the global agenda for sustainable development has contributed to a broader discussion around the interconnection between heritage and sustainability. However, the definitions of both concepts lack consensus. In the last decade, hundreds of definitions of sustainability can be identified in the scientific literature....
conference paper 2021
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Gonçalves, Joana (author), Clarke, Nicholas (author), de Ridder, A.C. (author)
book chapter 2021
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Gonçalves, Joana (author), Mateus, Ricardo (author), Dinis Silvestre, José (author), Pereira Roders, A. (author), Vasconcelos, Graça (author)
This paper presents and discusses the selection of a set of core indicators for the sustainable conservation of built heritage. This core set of indicators was selected by following a two-step methodology: 1) first, a comparative analysis of indicators of two building sustainability assessment (BSA) tools with different approaches was...
journal article 2021
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Gonçalves, Joana (author), Mateus, Ricardo (author), Silvestre, José Dinis (author), Pereira Roders, A. (author), Bragança, Luís (author)
This research applies the theory of planned behaviour (TPB) to measure the gap between designers’ intentions towards heritage conservation and the actual design decisions. It aims at contributing to identify which psychological constructs (attitude, norm, perception of control) are hindering the implementation of sustainable conservation...
journal article 2021
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Gonçalves, Joana (author), Mateus, Ricardo (author), Silvestre, José Dinis (author), Pereira Roders, A. (author)
Despite the recognised importance of built heritage for sustainable development, and the multiple tools, recommendations, guidelines, and policies developed in recent years to support decision-making, good sustainable conservation practices often fail to be implemented. Challenges faced by practitioners often relate to external factors, and...
journal article 2021
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Gonçalves, Joana (author), Mateus, Ricardo (author), Silvestre, José Dinis (author), Pereira Roders, A. (author)
This research addresses the performance gap between intentions towards a sustainable conservation of built heritage and its actual implementation. Socio-psychological models of human behaviour, such as the theory of planned behaviour (TPB), have been studying this dissonance between intention and behaviour, and allow to recognise latent...
review 2020
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Gisler, Santiago (author), P. Gonçalves, Joana (author), Akhtar, Waseem (author), de Jong, Johann (author), Pindyurin, Alexey V. (author), Wessels, L.F.A. (author), van Lohuizen, Maarten (author)
Understanding the impact of guide RNA (gRNA) and genomic locus on CRISPR-Cas9 activity is crucial to design effective gene editing assays. However, it is challenging to profile Cas9 activity in the endogenous cellular environment. Here we leverage our TRIP technology to integrate ~ 1k barcoded reporter genes in the genomes of mouse embryonic...
journal article 2019
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