Searched for: author:"Hang Wong, Tsz"
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Hang Wong, Tsz (author), van der Lee, S.J. (author), van Rooij, Jeroen G.J. (author), Meeter, Lieke H.H. (author), Frick, Petra (author), Melhem, Shamiram (author), Seelaar, Harro (author), Ikram, Mohammad A. (author), Holstege, H. (author), Hulsman, M. (author), More Authors (author)
Next-generation sequencing has contributed to our understanding of the genetics of Alzheimer's disease (AD) and has explained a substantial part of the missing heritability of familial AD. We sequenced 19 exomes from 8 Dutch families with a high AD burden and identified EIF2AK3, encoding for protein kinase RNA-like endoplasmic reticulum...
journal article 2019
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Holstege, H. (author), van der Lee, S.J. (author), Hulsman, M. (author), Hang Wong, Tsz (author), van Rooij, Jeroen (author), Weiss, Marjan M. (author), Louwersheimer, Eva (author), Wolters, Frank J, (author), Amin, Najaf (author), Reinders, M.J.T. (author), More Authors (author)
Accumulating evidence suggests that genetic variants in the SORL1 gene are associated with Alzheimer disease (AD), but a strategy to identify which variants are pathogenic is lacking. In a discovery sample of 115 SORL1 variants detected in 1908 Dutch AD cases and controls, we identified the variant characteristics associated with SORL1...
journal article 2017