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van der Burgh, B.J. (author), Filius, S.J. (author), Radaelli, G. (author), Harlaar, J. (author)Orthotic wrist supports will be beneficial for people with muscular weakness to keep their hand in a neutral rest position and prevent potential wrist contractures. Compensating the weight of the hands is complex since the level of support depends on both wrist and forearm orientations. To explore simplified approaches, two different weight...journal article 2024
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Veerkamp, Kirsten (author), van der Krogt, Marjolein M. (author), Waterval, Niels F.J. (author), Geijtenbeek, T. (author), Walsh, H. P.John (author), Harlaar, J. (author), Buizer, Annemieke I. (author), Lloyd, David G. (author), Carty, Christopher P. (author)Background: Most cases of toe walking in children are idiopathic. We used pathology-specific neuromusculoskeletal predictive simulations to identify potential underlying neural and muscular mechanisms contributing to idiopathic toe walking. Methods: A musculotendon contracture was added to the ankle plantarflexors of a generic musculoskeletal...journal article 2024
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Hulshof, Chantal M. (author), Schallig, Wouter (author), van den Noort, Josien C. (author), Streekstra, Geert J. (author), Kleipool, Roeland P. (author), GG Dobbe, Johannes (author), Maas, Mario (author), Harlaar, J. (author), van der Krogt, Marjolein M. (author)Segment coordinate systems (CSs) of marker-based multi-segment foot models are used to measure foot kinematics, however their relationship to the underlying bony anatomy is barely studied. The aim of this study was to compare marker-based CSs (MCSs) with bone morphology-based CSs (BCSs) for the hindfoot and forefoot. Markers were placed on...journal article 2024
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Haberfehlner, Helga (author), van de Ven, Shankara S. (author), van der Burg, Sven A. (author), Huber, Florian (author), Georgievska, Sonja (author), Aleo, Ignazio (author), Harlaar, J. (author), Bonouvrié, Laura A. (author), van der Krogt, Marjolein M. (author), Buizer, Annemieke I. (author)Introduction: Video-based clinical rating plays an important role in assessing dystonia and monitoring the effect of treatment in dyskinetic cerebral palsy (CP). However, evaluation by clinicians is time-consuming, and the quality of rating is dependent on experience. The aim of the current study is to provide a proof-of-concept for a machine...journal article 2023
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Waterval, N. F.J. (author), Brehm, M. A. (author), Veerkamp, K. (author), Geijtenbeek, T. (author), Harlaar, J. (author), Nollet, F. (author), van der Krogt, M. M. (author)To maximize effects of dorsal leaf ankle foot orthoses (AFOs) on gait in people with bilateral plantarflexor weakness, the AFO properties should be matched to the individual. However, how AFO properties interact regarding their effect on gait function is unknown. We studied the interaction of AFO bending stiffness with neutral angle and...journal article 2023
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Waterval, N. F.J. (author), van der Krogt, M. M. (author), Veerkamp, K. (author), Geijtenbeek, T. (author), Harlaar, J. (author), Nollet, F. (author), Brehm, M. A. (author)Background: The stiffness of a dorsal leaf AFO that minimizes walking energy cost in people with plantarflexor weakness varies between individuals. Using predictive simulations, we studied the effects of plantarflexor weakness, passive plantarflexor stiffness, body mass, and walking speed on the optimal AFO stiffness for energy cost reduction...journal article 2023
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Filius, S.J. (author), Janssen, Mariska (author), van der Kooij, H. (author), Harlaar, J. (author)People with severe muscle weakness in the upper extremity are in need of an arm support to enhance arm function and improve their quality of life. In addition to weight support, compensation of passive joint impedance (pJimp) seems necessary. Existing devices do not compensate for pJimp yet, and the best way to compensate for it is still unknown...conference paper 2023
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Jabeen, S. (author), Baines, P.M. (author), Harlaar, J. (author), Vallery, H. (author), Berry, Andrew (author)Balance recovery after tripping often requires an active adaptation of foot placement. Thus far, few attempts have been made to actively assist forward foot placement for balance recovery employing wearable devices. This study aims to explore the possibilities of active forward foot placement through two paradigms of actuation: assistive...journal article 2023
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Veerkamp, Kirsten (author), Carty, Christopher P. (author), Waterval, Niels F.J. (author), Geijtenbeek, T. (author), Buizer, Annemieke I. (author), Lloyd, David G. (author), Harlaar, J. (author), van der Krogt, Marjolein M. (author)Spasticity is a common impairment within pediatric neuromusculoskeletal disorders. How spasticity contributes to gait deviations is important for treatment selection. Our aim was to evaluate the pathophysiological mechanisms underlying gait deviations seen in children with spasticity, using predictive simulations. A cluster analysis was...journal article 2023
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Flux, Eline (author), Bar-On, Lynn (author), Buizer, Annemieke I. (author), Harlaar, J. (author), van der Krogt, Marjolein M. (author)Background: Children with cerebral palsy often show deviating calf muscle activation patterns during gait, with excess activation during early stance and insufficient activation during push-off. Research question: Can children with cerebral palsy improve their calf muscle activation patterns during gait using one session of biofeedback-driven...journal article 2023
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Satam, Anuja P. (author), van der Leeden, Marike (author), de Zwart, Arjan (author), Verberne, Simon (author), Schrijvers, Jim C. (author), Hall, Michelle (author), Dekker, Joost (author), Lems, Willem F. (author), Harlaar, J. (author), van der Esch, Martin (author)Background: Muscle weakness is characteristic of knee osteoarthritis. Muscle steadiness may be an important adjunct to knee muscle strength in improving physical function in knee osteoarthritis. However, the role of muscle steadiness is uncertain. Aims: To determine the associations of knee extensor muscle steadiness with maximal voluntary...journal article 2022
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Harlaar, J. (author), Macri, E.M. (author), Wesseling, M.G.H. (author)Osteoarthritis (OA) has a complex, heterogeneous and only partly understood etiology. There is a definite role of joint cartilage pathomechanics in originating and progressing of the disease. Although it is still not identified precisely enough to design or select targeted treatments, the progress of this year's research demonstrates that...review 2022
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Waterval, N.F.J. (author), Brehm, M. A. (author), Harlaar, J. (author), Nollet, F. (author)Background: In individuals with unilateral plantar flexor weakness, the second peak of the vertical ground reaction force (GRF) is decreased. This leads to a higher ground reaction force, e.g. impact, of the contralateral leg, potentially explaining quadriceps muscle and/or knee joint pain. Energy cost optimized dorsal leaf ankle-foot...journal article 2022
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Booij, M.J. (author), van Royen, B. J. (author), Nolte, P. A. (author), Twisk, J. W.R. (author), Harlaar, J. (author), van den Noort, J. C. (author)Background: Gait adaptability is of utmost importance for keeping balance during gait in patients with knee osteoarthritis, also after total knee arthroplasty (TKA). The aims of this explorative study are: (1) assess the effect of age, knee osteoarthritis and TKA on gait adaptability; (2) assess changes in gait adaptability pre-to post-TKA...journal article 2022
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Schallig, Wouter (author), van den Noort, Josien C. (author), Piening, Marjolein (author), Streekstra, Geert J. (author), Maas, Mario (author), van der Krogt, Marjolein M. (author), Harlaar, J. (author)Background: Foot and ankle joint kinematics are measured during clinical gait analyses with marker-based multi-segment foot models. To improve on existing models, measurement errors due to soft tissue artifacts (STAs) and marker misplacements should be reduced. Therefore, the aim of this study is to define a clinically informed, universally...journal article 2022
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Veerkamp, Kirsten (author), van der Krogt, Marjolein M. (author), Harlaar, J. (author), O’Brien, Thomas D. (author), Kalkman, Barbara (author), Seth, A. (author), Bar-On, Lynn (author)Neuromusculoskeletal models can be used to evaluate aberrant muscle function in cerebral palsy (CP), for example by estimating muscle and joint contact forces during gait. However, to be accurate, models should include representative musculotendon parameters. We aimed to estimate personalised parameters that capture the mechanical behaviour...journal article 2022
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- Veerkamp, Kirsten (author), van der Krogt, Marjolein M. (author), Waterval, Niels F.J. (author), Geijtenbeek, T. (author), Walsh, Henry P.J. (author), Harlaar, J. (author), Buizer, Annemieke I. (author), Lloyd, David G. (author), Carty, Christopher P. (author) journal article 2022
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Urbanus, Francine C.A. (author), Grayson, Jane (author), Harlaar, J. (author), Simic, Milena (author)Load modifying gait retraining strategies, such as changing the foot progression angle (FPA) to toe-in and toe-out gait, are used for people with medial knee osteoarthritis. The FPA can be measured using a pressure sensitive walkway (PSW), but inertial measurement units (IMUs) are considered more suitable for clinical use. This study...journal article 2022
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McCahill, Jennifer (author), Stebbins, Julie (author), Prescott, Robin J. (author), Harlaar, J. (author), Theologis, Tim (author)Background: The Foot Profile Score (FPS) is a single score that summarises foot posture and dynamic foot motion during the gait cycle based on the kinematic data of the Oxford Foot Model. The FPS enables clinicians and researchers to quantify foot abnormalities during gait, to monitor change in foot/ankle motion over time, and to measure the...journal article 2022
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Den Hartog, Dylan (author), van der Krogt, Marjolein M. (author), van der Burg, Sven (author), Aleo, Ignazio (author), Gijsbers, Johannes (author), Bonouvrié, Laura A. (author), Harlaar, J. (author), Buizer, Annemieke I. (author), Haberfehlner, Helga (author)Accurate and reliable measurement of the severity of dystonia is essential for the indication, evaluation, monitoring and fine‐tuning of treatments. Assessment of dystonia in children and adolescents with dyskinetic cerebral palsy (CP) is now commonly performed by visual evaluation either directly in the doctor’s office or from video...journal article 2022