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Diffuse reflectance spectroscopy of the spine: improved breach detection with angulated fibers

Losch, M.S. (author), Kardux, Famke (author), Dankelman, J. (author), Hendriks, B.H.W. (author)

Accuracy in spinal fusion varies greatly depending on the experience of the physician. Real-time tissue feedback with diffuse reflectance spectroscopy has been shown to provide cortical breach detection using a conventional probe with two parallel fibers. In this study, Monte Carlo simulations and optical phantom experiments were conducted to...

journal article 2023

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Imaging Photoplethysmography for Noninvasive Anastomotic Perfusion Assessment in Intestinal Surgery

van der Stel, Stefan D. (author), Lai, Marco (author), Groen, Harald C. (author), Witteveen, Mark (author), Kuhlmann, Koert F.D. (author), Grotenhuis, Brechtje A. (author), Kok, Niels F.M. (author), van Gastel, Mark (author), Hendriks, B.H.W. (author), Ruers, Theo J.M. (author)

Introduction: Anastomotic leakage after gastrointestinal surgery has a high impact on patient's quality of life and its origin is associated with inadequate perfusion. Imaging photoplethysmography (iPPG) is a noninvasive imaging technique that measures blood-volume changes in the microvascular tissue bed and detects changes in tissue...

journal article 2023

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Automatic Camera Pose Estimation by Key-Point Matching of Reference Objects

Zeng, Jinchen (author), Butler, R.M. (author), van den Dobbelsteen, J.J. (author), Hendriks, B.H.W. (author), van der Elst, M. (author), Dauwels, J.H.G. (author)

In this paper, we aim to design an automatic camera pose estimation pipeline for clinical spaces such as catheterization laboratories. Our proposed pipeline exploits Scaled-YOLOv4 to detect fixed objects. We adopt the self-supervised key-point detector SuperPoint in combination with SuperGlue, a keypoint matching technique based on graph neural...

conference paper 2023

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Hyperspectral Imaging for Tissue Classification after Advanced Stage Ovarian Cancer Surgery: A Pilot Study

Perez, S.M. (author), van de Berg, N.J. (author), Manni, Francesca (author), Lai, Marco (author), Rijstenberg, Lucia (author), Hendriks, B.H.W. (author), Dankelman, J. (author), Ewing-Graham, Patricia C. (author), Nieuwenhuyzen, G.M. (author), Van Beekhuizen, Heleen J. (author)

The most important prognostic factor for the survival of advanced-stage epithelial ovarian cancer (EOC) is the completeness of cytoreductive surgery (CRS). Therefore, an intraoperative technique to detect microscopic tumors would be of great value. The aim of this pilot study is to assess the feasibility of near-infrared hyperspectral imaging ...

journal article 2022

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Development of a CT-Compatible, Anthropomorphic Skull and Brain Phantom for Neurosurgical Planning, Training, and Simulation

Lai, Marco (author), Skyrman, Simon (author), Kor, Flip (author), Homan, Robert (author), El-Hajj, Victor Gabriel (author), Babic, Drazenko (author), Edstrom, Erik (author), Terander, Adrian Elmi (author), Hendriks, B.H.W. (author), De With, Peter H.N. (author)

Background: Neurosurgical procedures are complex and require years of training and experience. Traditional training on human cadavers is expensive, requires facilities and planning, and raises ethical concerns. Therefore, the use of anthropomorphic phantoms could be an excellent substitute. The aim of the study was to design and develop a...

journal article 2022

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Tissue-mimicking phantom materials with tunable optical properties suitable for assessment of diffuse reflectance spectroscopy during electrosurgery

Azizian Amiri, S. (author), van Berckel, Pieter (author), Lai, Marco (author), Dankelman, J. (author), Hendriks, B.H.W. (author)

Emerging intraoperative tumor margin assessment techniques require the development of more complex and reliable organ phantoms to assess the performance of the technique before its translation into the clinic. In this work, electrically conductive tissue-mimicking materials (TMMs) based on fat, water and agar/gelatin were produced with...

journal article 2022

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Imaging PPG for In Vivo Human Tissue Perfusion Assessment during Surgery

Lai, Marco (author), van der Stel, Stefan D. (author), Groen, Harald C. (author), van Gastel, Mark (author), Kuhlmann, Koert F.D. (author), Ruers, Theo J.M. (author), Hendriks, B.H.W. (author)

Surgical excision is the golden standard for treatment of intestinal tumors. In this surgical procedure, inadequate perfusion of the anastomosis can lead to postoperative complications, such as anastomotic leakages. Imaging photoplethysmography (iPPG) can potentially provide objective and real-time feedback of the perfusion status of tissues....

journal article 2022

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Steering light in fiber-optic medical devices: a patent review

Losch, M.S. (author), Kardux, Famke (author), Dankelman, J. (author), Hendriks, B.H.W. (author)

Introduction: Steering light is relevant to many medical applications that require tissue illumination, sensing, or modification. To control the propagation direction of light beams, a great variety of innovative fiber-optic medical devices have been designed. Areas covered: This review provides a comprehensive overview of the patent...

review 2022

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Diffuse reflectance spectroscopy sensor to differentiate between glial tumor and healthy brain tissue: A proof-of-concept study

Skyrman, Simon (author), Burström, Gustav (author), Lai, Marco (author), Manni, Francesca (author), Hendriks, B.H.W. (author), Frostell, Arvid (author), Edström, Erik (author), Persson, Oscar (author), Elmi-Terander, Adrian (author)

Glial tumors grow diffusely in the brain. Survival is correlated to the extent of tumor removal, but tumor borders are often invisible. Resection beyond the borders as defined by conventional methods may further improve prognosis. In this proof-of-concept study, we evaluate diffuse reflectance spectroscopy (DRS) for discrimination between...

journal article 2022

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Reprocessing Zamak laryngoscope blades into new instrument parts: an ‘all-in-one’ experimental study

van Straten, Bart (author), Tantuo, B.N. (author), Sperna Weiland, Nicolaas H. (author), Dankelman, J. (author), Hendriks, B.H.W. (author), Horeman, T. (author)

Introduction: Disposable instruments in healthcare have led to a significant increase of medical waste. The aim of this study is to validate the recycling of disposable Zamak laryngoscope blades into new medical products by using a new ‘all-in-one’ affordable reprocessing setup as alternative for die-casting. <br/>Methods: An “all-in-one”...

journal article 2022

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Layer thickness prediction and tissue classification in two-layered tissue structures using diffuse reflectance spectroscopy

Geldof, Freija (author), Dashtbozorg, Behdad (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)

During oncological surgery, it can be challenging to identify the tumor and establish adequate resection margins. This study proposes a new two-layer approach in which diffuse reflectance spectroscopy (DRS) is used to predict the top layer thickness and classify the layers in two-layered phantom and animal tissue. Using wavelet-based and peak...

journal article 2022

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Electrosurgical knife equipped with diffused reflectance spectroscopy sensing for tumor margin detection during breast conserving surgery: A phantom study

Azizian Amiri, S. (author), van Berckel, Pieter (author), Dankelman, J. (author), Hendriks, B.H.W. (author)

Distinguishing the diseased breast tissue from the healthy tissue is a sorely challenging task for the surgeons during breast conserving surgery (BCS) as both tissues own relatively similar visual and haptic characteristics. It has been shown that diffused reflectance spectroscopy (DRS) has the potential to be used as a real-time tumor margin...

conference paper 2021

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Proton density fat fraction of the spinal column: an MRI cadaver study

Losch, M.S. (author), Swamy, A. (author), Elmi-Terander, Adrian (author), Edström, Erik (author), Hendriks, B.H.W. (author), Dankelman, J. (author)

Background: The increased popularity of minimally invasive spinal surgery calls for a revision of guidance techniques to prevent injuries of nearby neural and vascular structures. Lipid content has previously been proposed as a distinguishing criterion for different bone tissues to provide guidance along the interface of cancellous and...

journal article 2021

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Evaluation of a non-contact Photo-Plethysmographic Imaging (iPPG) system for peripheral arterial disease assessment

Lai, Marco (author), Dicorato, Claudio Spiridione (author), de Wild, Marco (author), Verbakel, Frank (author), Shulepov, Sergei (author), Groen, Joanneke (author), Notten, Marc (author), Lucassen, Gerald (author), Van Sambeek, Marc R.H.M. (author), Hendriks, B.H.W. (author), de With, Peter H.N. (author)

Peripheral Artery Diseases (PAD) are caused by the occlusions of arteries in the peripheral locations of the circulatory system. The severity of PAD is usually assessed using the Ankle Brachial Index (ABI) and the Ultrasound Doppler. Non-contact Photoplethysmography (PPG) imaging is a recent emerging technology capable of monitoring skin...

conference paper 2021

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Development of a CT-compatible anthropomorphic skull phantom for surgical planning, training, and simulation

Lai, Marco (author), Skyrman, Simon (author), Kor, Flip (author), Homan, Robert (author), Babic, Drazenko (author), Edström, Erik (author), Persson, Oscar (author), Burström, Gustav (author), Elmi-Terander, Adrian (author), Hendriks, B.H.W. (author), De With, Peter H.N. (author)

Neurosurgical training is performed on human cadavers and simulation models, such as VR platforms, which have several drawbacks. Head phantoms could solve most of the issues related to these trainings. The aim of this study was to design a realistic and CT-compatible head phantom, with a specific focus on endo-nasal skull-base surgery and...

conference paper 2021

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Optical tissue measurements of invasive carcinoma and ductal carcinoma in situ for surgical guidance

de Boer, Lisanne L. (author), Kho, Esther (author), Van de Vijver, Koen K. (author), Vranken Peeters, Marie Jeanne T.F.D. (author), van Duijnhoven, Frederieke (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)

Background: Although the incidence of positive resection margins in breast-conserving surgery has decreased, both incomplete resection and unnecessary large resections still occur. This is especially the case in the surgical treatment of ductal carcinoma in situ (DCIS). Diffuse reflectance spectroscopy (DRS), an optical technology based on...

journal article 2021

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Combining diffuse reflectance spectroscopy and ultrasound imaging for resection margin assessment during colorectal cancer surgery

Geldof, Freija (author), Jong, Lynn-Jade (author), Dashtbozorg, Behdad (author), Hendriks, B.H.W. (author), Sterenborg, Henricus J.C.M. (author), Ruers, Theo J.M. (author)

Establishing adequate resection margins during colorectal cancer surgery is challenging. Currently, in up to 30% of the cases the tumor is not completely removed, which emphasizes the lack of a real-time tissue discrimination tool that can assess resection margins up to multiple millimeters in depth. Therefore, we propose to combine spectral...

conference paper 2021

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Fusion of augmented reality imaging with the endoscopic view for endonasal skull base surgery: a novel application for surgical navigation based on intraoperative cone beam computed tomography and optical tracking

Lai, Marco (author), Skyrman, Simon (author), Shan, Caifeng (author), Babic, Drazenko (author), Homan, Robert (author), Edström, Erik (author), Persson, Oscar (author), Burström, Gustav (author), Elmi-Terander, Adrian (author), Hendriks, B.H.W. (author), de With, Peter H.N. (author)

OBJECTIVE: Surgical navigation is a well-established tool in endoscopic skull base surgery. However, navigational and endoscopic views are usually displayed on separate monitors, forcing the surgeon to focus on one or the other. Aiming to provide real-time integration of endoscopic and diagnostic imaging information, we present a new...

review 2020

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Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: The effect of electrosurgery on tissue discrimination using ex vivo animal tissue models

Azizian Amiri, S. (author), van Gent, Carlijn M. (author), Dankelman, J. (author), Hendriks, B.H.W. (author)

Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance of an electrosurgical knife...

journal article 2020

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Automated classification of brain tissue: Comparison between hyperspectral imaging and diffuse reflectance spectroscopy

Lai, Marco (author), Skyrman, Simon (author), Shan, Caifeng (author), Paulussen, Elvira (author), Manni, Francesca (author), Swamy, A. (author), Babic, Drazenko (author), Edstrom, Erik (author), Persson, Oscar (author), Burstrom, Gustav (author), Elmi-Terander, Adrian (author), Hendriks, B.H.W. (author), De With, Peter H.N. (author)

In neurosurgery, technical solutions for visualizing the border between healthy brain and tumor tissue is of great value, since they enable the surgeon to achieve gross total resection while minimizing the risk of damage to eloquent areas. By using real-time non-ionizing imaging techniques, such as hyperspectral imaging (HSI), the spectral...

conference paper 2020