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Zonneveld, Hazel I. (author), Pruim, R.H.R. (author), Bos, Daniel (author), Vrooman, Henri A. (author), Muetzel, Ryan L. (author), Hofman, Albert (author), Rombouts, Serge ARB (author), van der Lugt, Aad (author), Niessen, W.J. (author)Structural brain markers are studied extensively in the field of neurodegeneration, but are thought to occur rather late in the process. Functional measures such as functional connectivity are gaining interest as potentially more subtle markers of neurodegeneration. However, brain structure and function are also affected by ‘normal’ brain...journal article 2019
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van der Lee, Sven J. (author), Roshchupkin, Gennady V. (author), Adams, Hieab H. (author), Schmidt, Helena (author), Hofer, Edith (author), Saba, Yasaman (author), Schmidt, Reinhold (author), Hofman, Albert (author), Amin, Najaf (author), van Duijn, Cornelia M. (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author), Niessen, W.J. (author)Background: The combination of genetics and imaging has improved their understanding of the brain through studies of aggregate measures obtained from high-resolution structural imaging. Voxel-wise analyses have the potential to provide more detailed information of genetic influences on the brain. Here they report a large-scale study of the...journal article 2017
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Roshchupkin, Gennady V. (author), Gutman, Boris A. (author), Vernooij, Meike W. (author), Jahanshad, Neda (author), Martin, Nicholas G. (author), Hofman, Albert (author), McMahon, Katie L. (author), van der Lee, S.J. (author), van Duijn, Cornelia M. (author), De Zubicaray, Greig I. (author), Uitterlinden, André G. (author), Wright, Margaret J. (author), Niessen, W.J. (author), Thompson, Paul M. (author), Ikram, M. Arfan (author), Adams, Hieab H. (author)The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum,...journal article 2016
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Selwaness, Mariana (author), Hameeteman, Reinhard (author), Van 't Klooster, Ronald (author), Van den Bouwhuijsen, Quirijn (author), Hofman, Albert (author), Franco, Oscar H. (author), Niessen, W.J. (author), Klein, Stefan (author), Vernooij, Meike W. (author), Van der Lugt, Aad (author), Wentzel, Jolanda J. (author)Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer...journal article 2016
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Evans, Tavia E. (author), O'Sullivan, Michael J. (author), De Groot, Marius (author), Niessen, W.J. (author), Hofman, Albert (author), Krestin, Gabriel P. (author), Van Der Lugt, Aad (author), Portegies, Marileen L P (author), Koudstaal, Peter J. (author), Bos, Daniel (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author)Background and Purpose - The presence of subclinical vascular brain disease, including white matter lesions and lacunar infarcts, substantially increases the risk of clinical stroke. White matter microstructural integrity is considered an earlier, potentially better, marker of the total burden of vascular brain disease. Its association with...journal article 2016