Searched for: author:"Hol, F.J.H."
(1 - 8 of 8)
document
Hol, F.J.H. (author), Rotem, Or (author), Jurkevitch, Edouard (author), Dekker, C. (author), Koster, D. (author)
Soil is a microenvironment with a fragmented (patchy) spatial structure in which many bacterial species interact. Here, we explore the interaction between the predatory bacterium Bdellovibrio bacteriovorus and its prey Escherichia coli in microfabricated landscapes. We ask how fragmentation influences the prey dynamics at the microscale and...
journal article 2016
document
Hol, F.J.H. (author), Hubert, A.W.R. (author), Dekker, C. (author), Keymer Vergara, J.E. (author)
During antibiotic treatment, antibiotic concentration gradients develop. Little is know regarding the effects of antibiotic gradients on populations of nonresistant bacteria. Using a microfluidic device, we show that high-density motile Escherichia coli populations composed of nonresistant bacteria can, unexpectedly, colonize environments...
journal article 2016
document
Hol, F.J.H. (author), Galajda, P. (author), Woolthuis, R.G. (author), Dekker, C. (author), Keymer, J.E. (author)
Background The spatial structure of a habitat can have a strong impact on community dynamics. Different experimental approaches exist to explore the effect of spatial structure on bacterial communities. To investigate the effect of ‘space’, a single implementation of spatial structure is often contrasted to bacterial community dynamics in well...
journal article 2015
document
Hol, F.J.H. (author), Voges, M.J. (author), Dekker, C. (author), Keymer, J.E. (author)
Background: Antagonistic interactions mediated by antibiotics are strong drivers of bacterial community dynamics which shape biodiversity. Colicin production by Escherichia coli is such an interaction that governs intraspecific competition and is involved in promoting biodiversity. It is unknown how environmental cues affect regulation of the...
journal article 2014
document
Hol, F.J.H. (author)
In this thesis, I describe experiments aimed at understanding bacterial population dynamics in ecosystems that are spatially structured at the micro-scale. We combine microfabrication and microfluidics to create synthetic ecosystems that have a complex yet well-defined geometry and chemical composition. Bacteria that inhabit such ecosystems can...
doctoral thesis 2014
document
Van Vliet, S. (author), Hol, F.J.H. (author), Weenink, T. (author), Galajda, P. (author), Keymer, J.E. (author)
Background Bacterial habitats, such as soil and the gut, are structured at the micrometer scale. Important aspects of microbial life in such spatial ecosystems are migration and colonization. Here we explore the colonization of a structured ecosystem by two neutrally labeled strains of Escherichia coli. Using time-lapse microscopy we studied the...
journal article 2014
document
Hol, F.J.H. (author), Galajda, P. (author), Nagy, K. (author), Woolthuis, R.G. (author), Dekker, C. (author), Keymer, J.E. (author)
Cooperative organisms are ubiquitous in nature, despite their vulnerability to exploitation by cheaters. Although numerous theoretical studies suggest that spatial structure is critical for cooperation to persist, the spatial ecology of microbial cooperation remains largely unexplored experimentally. By tracking the community dynamics of...
journal article 2013
document
Männik, J. (author), Wu, F. (author), Hol, F.J.H. (author), Bisicchia, P. (author), Sherratt, D.J. (author), Keymer, J.E. (author), Dekker, C. (author)
Cell division in typical rod-shaped bacteria such as Escherichia coli shows a remarkable plasticity in being able to adapt to a variety of irregular cell shapes. Here, we investigate the roles of the Min system and the nucleoid-occlusion factor SlmA in supporting this adaptation. We study “squeezed” E. coli in narrow nanofabricated channels...
journal article 2012
Searched for: author:"Hol, F.J.H."
(1 - 8 of 8)