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Modeling the Effect of Wave-front Aberrations in Fiber-based Scanning Optical Microscopy

Verstraete, H.R.G.W. (author), Verhaegen, M.H.G. (author), Kalkman, J. (author)

In scanning microscopy and optical coherence tomography, aberrations of the wave-front cause a loss in intensity and resolution. Intensity and resolution are quantified using Fresnel propagation, Fraunhofer diffraction, and the calculation of overlap integrals.

conference paper 2013

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Localized measurement of longitudinal and transverse flow velocities in colloidal suspensions using optical coherence tomography

Weiss, N. (author), Van Leeuwen, T.G. (author), Kalkman, J. (author)

We report on localized measurement of the longitudinal and transverse flow velocities in a colloidal suspension using optical coherence tomography. We present a model for the path-length resolved autocorrelation function including diffusion and flow, which we experimentally verify. For flow that is not perpendicular to the incident beam, the...

journal article 2013

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Ultra-compact silicon photonic integrated interferometer for swept-source optical coherence tomography

Yurtsever, G. (author), Weiss, N. (author), Kalkman, J. (author), Van Leeuwen, T.G. (author), Baets, R. (author)

We demonstrate an ultra-compact silicon integrated photonic interferometer for swept-source optical coherence tomography (SS-OCT). The footprint of the integrated interferometer is only 0.75×5??mm2. The design consists of three 2×2 splitters, a 13 cm physical length (50.4 cm optical length) reference arm, and grating couplers. The photonic...

journal article 2014

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Feedforward operation of a lens setup for large defocus and astigmatism correction

Verstraete, H.R.G.W. (author), Almasian, M. (author), Pozzi, P. (author), Bilderbeek, R (author), Kalkman, J. (author), Faber, DJ (author), Verhaegen, M.H.G. (author)

In this manuscript, we present a lens setup for large defocus and astigmatism correction. A deformable defocus lens and two rotational cylindrical lenses are used to control the defocus and astigmatism. The setup is calibrated using a simple model that allows the calculation of the lens inputs so that a desired defocus and astigmatism are...

conference paper 2016

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Image resolution and deconvolution in optical tomography

van der Horst, J. (author), Kalkman, J. (author)

We present a frequency domain analysis of the image resolution of optical tomography systems. The result of our analysis is a description of the spatially-variant resolution in optical tomographic image after reconstruction as a function of the properties of the imaging system geometry. We validate our model using optical projection...

journal article 2016

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Temperature-immune readout of an integrated optical wavelength meter based on microring resonators

Taballione, Caterina (author), Agbana, T.E. (author), Vdovin, Gleb (author), Hoekman, Marcel (author), Wevers, Lennart (author), Kalkman, J. (author), Verhaegen, M.H.G. (author), van der Slot, Peter J.M. (author), Boller, Klaus-Jochen (author)

Wavelength meters are central for many applications such as in telecommunication systems or laser monitoring. The primary function of a wavelength meter is to provide an output signal that changes sensitively with the wavelength of the input light. Of central importance is the reproducibility of the output signal even in the presence of external...

poster 2017

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Point spread function based image reconstruction in optical projection tomography

Trull, A.K. (author), van der Horst, J. (author), Palenstijn, W.J. (author), van Vliet, L.J. (author), van Leeuwen, Tristan (author), Kalkman, J. (author)

As a result of the shallow depth of focus of the optical imaging system, the use of standard filtered back projection in optical projection tomography causes space-variant tangential blurring that increases with the distance to the rotation axis. We present a novel optical tomographic image reconstruction technique that incorporates the point...

journal article 2017

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Temperature-drift-immune wavelength meter based on an integrated micro-ring resonator

Taballione, C. (author), Agbana, T.E. (author), Vdovin, Gleb (author), Hoekman, M (author), Wevers, L. (author), Kalkman, J. (author), Verhaegen, M.H.G. (author), van der Slot, P.J.M. (author), Boller, KJ (author)

conference paper 2017

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Fourier-Domain Optical Coherence Tomography Signal Analysis and Numerical Modeling

Kalkman, J. (author)

journal article 2017

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Axial-resolution in depth from focus digital holography

van Rooij, J. (author), Kalkman, J. (author)

We use digital holography to quantify surface topography of rough objects in full-field. We calculate the variance of the intensity image as a focus metric over a set of reconstruction distances for each pixel, which results in a focus metric curve. The distance where the variance peaks is an estimate for the depth. First we analyze the lateral...

conference paper 2017

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Segmentation of thin corrugated layers in high-resolution OCT images

Dore-Callewaert, T.W.J. (author), Dik, J. (author), Kalkman, J. (author)

In this paper we present a novel method for the segmentation of thin corrugated layers in high resolution optical coherence tomography (OCT) images. First, we make an initial segmentation, for example with graph based segmentation that, for highly corrugated interfaces, leads to many segmentation errors. Second, we resegment the initial...

journal article 2017

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Comparison of image reconstruction techniques for optical projection tomography

Trull, A.K. (author), van der Horst, J. (author), van Vliet, L.J. (author), Kalkman, J. (author)

We present a comparison of image reconstruction techniques for optical projection tomography. We compare conventional filtered back projection, sinogram filtering using the frequency–distance relationship (FDR), image deconvolution, and 2D point-spread-function-based iterative reconstruction. The latter three methods aim to remove the spatial...

journal article 2018

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Optical coherence computed tomography for quantitative 3D imaging of adult zebrafish (Withdrawal Notice)

van der Horst, J. (author), Trull, A.K. (author), Kalkman, J. (author)

conference paper 2018

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Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom

Ghafaryasl, B. (author), Vermeer, K.A. (author), Kalkman, J. (author), Dore-Callewaert, T.W.J. (author), de Boer, J.F. (author), van Vliet, L.J. (author)

The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm,...

conference paper 2018

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Large-scale high-sensitivity optical diffraction tomography of Zebrafish

van Rooij, J. (author), Kalkman, J. (author)

In this work we demonstrate large-scale high-sensitivity optical diffraction tomography (ODT) of zebrafish. We make this possible by three improvements. First, we obtain a large field of view while still maintaining a high resolution by using a high magnification over numerical aperture ratio digital holography set-up. With the inclusion of...

journal article 2019

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Quantification of plant morphology and leaf thickness with optical coherence tomography

de Wit, J. (author), Tonn, Sebastian (author), van den Ackerveken, Guido (author), Kalkman, J. (author)

Optical coherence tomography (OCT) can be a valuable imaging tool for in vivo and label-free digital plant phenotyping. However, for imaging leaves, air-filled cavities limit the penetration depth and reduce the image quality. Moreover, up to now quantification of leaf morphology with OCT has been done in one-dimensional or two-dimensional...

journal article 2020

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Deep-tissue label-free quantitative optical tomography

van der Horst, J. (author), Trull, A.K. (author), Kalkman, J. (author)

In vivo imaging of small animals is of wide interest to the biomedical community studying biological disease and developmental processes. However, optical imaging deep in tissue is severely limited by light scattering, posing restrictions on the imaging depth, image contrast, and spatial resolution. We demonstrate optical coherence projection...

journal article 2020

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Polarization contrast optical diffraction tomography

van Rooij, J. (author), Kalkman, J. (author)

We demonstrate large scale polarization contrast optical diffraction tomography (ODT). In cross-polarized sample arm detection configuration we determine, from the amplitude of the optical wavefield, a relative measure of the birefringence projection. In parallel-polarized sample arm detection configuration we image the conventional phase...

journal article 2020

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Multi-scale optical coherence tomography imaging and visualization of Vermeer’s Girl with a Pearl Earring

Dore-Callewaert, T.W.J. (author), Guo, Jerry Jinfeng (author), Harteveld, G.I. (author), Vandivere, Abbie (author), Dik, J. (author), Eisemann, E. (author), Kalkman, J. (author)

We demonstrate multi-scale multi-parameter optical coherence tomography (OCT) imaging and visualization of Johannes Vermeer’s painting Girl with a Pearl Earring. Through automated acquisition, OCT image segmentation, and 3D volume stitching we realize OCT imaging at the scale of an entire painting. This makes it possible to image, with...

journal article 2020

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Analysis of attenuation coefficient estimation in Fourier-domain OCT of semi-infinite media

Ghafaryasl, B. (author), Vermeer, Koenraad A. (author), Kalkman, J. (author), Dore-Callewaert, T.W.J. (author), Boer, Johannes F.D.E. (author), van Vliet, L.J. (author)

The attenuation coefficient (AC) is an optical property of tissue that can be estimated from optical coherence tomography (OCT) data. In this paper, we aim to estimate the AC accurately by compensating for the shape of the focused beam. For this, we propose a method to estimate the axial PSF model parameters and AC by fitting a model for an...

journal article 2020