Searched for: author%3A%22Kouwenberg%2C+J.J.M.%22
(1 - 8 of 8)
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Kouwenberg, J.J.M. (author)
Alpha radionuclide therapy has great potential for effective treatment of metastatic with reduced normal tissue complications. (Pre-clinical) research of alpha radiation of therapy does however suffer from a lack of proper tools for spectroscopy, (micro-) dosimetry and radiobiology. An attempt was made to develop and verify methods for the...
doctoral thesis 2018
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Kouwenberg, J.J.M. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), bos, A.J.J. (author)
Background: While alpha microdosimetry dates back a couple of decades, the effects of localized energy deposition of alpha particles are often still unclear since few comparative studies have been performed. Most modern alpha microdosimetry studies rely for large parts on simulations, which negatively impacts both the simplicity of the...
journal article 2018
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Kouwenberg, J.J.M. (author), Kremers, G. J. (author), Slotman, J. A. (author), Wolterbeek, H.T. (author), Houtsmuller, A.B. (author), Denkova, A.G. (author), bos, A.J.J. (author)
Structured illumination microscopy (SIM) for the imaging of alpha particle tracks in fluorescent nuclear track detectors (FNTD) was evaluated and compared to confocal laser scanning microscopy (CLSM). FNTDs were irradiated with an external alpha source and imaged using both methodologies. SIM imaging resulted in improved resolution, without...
journal article 2018
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Akselrod, Mark (author), Kouwenberg, J.J.M. (author)
Fluorescent Nuclear Track Detector technology is a passive luminescent integrating detector technology having important advantages in measuring neutrons, heavy ions and even photons. FNTD is based on new aluminum oxide crystals doped with carbon and magnesium impurities (Al<sub>2</sub>O<sub>3</sub>:C,Mg) and confocal laser scanning...
review 2018
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de Kruijff, R.M. (author), van der Meer, A.J.G.M. (author), Windmeijer, C.A.A. (author), Kouwenberg, J.J.M. (author), Morgenstern, A. (author), Bruchertseifer, F. (author), Sminia, P. (author), Denkova, A.G. (author)
Alpha emitters have great potential in targeted tumour therapy, especially in destroying micrometastases, due to their high linear energy transfer (LET). To prevent toxicity caused by recoiled daughter atoms in healthy tissue, alpha emitters like <sup>225</sup>Ac can be encapsulated in polymeric nanocarriers (polymersomes), which are capable...
journal article 2018
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Kouwenberg, J.J.M. (author), de Pooter, J. A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), bos, A.J.J. (author)
To answer the need for better tools for alpha radiation radiobiology and microdosimetry research, a novel irradiation setup based on a honeycomb collimator, in combination with Fluorescent Nuclear Track Detectors (FNTD) for alpha radiation dosimetry and spectroscopy, was introduced. FNTDs are a novel type of small, crystalline detector that...
journal article 2018
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Kouwenberg, J.J.M. (author), Ulrich, Leonie (author), Jäkel, Oliver (author), Greilich, Steffen (author)
A robust and computationally efficient algorithm for automated tracking of high densities of particles travelling in (semi-) straight lines is presented. It extends the implementation of (Sbalzarini and Koumoutsakos 2005) and is intended for use in the analysis of single ion track detectors. By including information of existing tracks in the...
journal article 2016
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Kouwenberg, J.J.M. (author)
Objective: Prostate cancer remains one of the most prevalent forms of cancer in men aged over 65 years, with yearly around 11,200 new cases and 2,600 deaths in the Netherlands. Diagnosis of prostate cancer still relies on biopsies, which are unpleasant and invasive procedures for the patient. The new PET tracer, [68Ga]Sarabesin 3, aims to offer...
master thesis 2015
Searched for: author%3A%22Kouwenberg%2C+J.J.M.%22
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