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Vente, M.A.D. (author), Nijsen, J.F.W. (author), De Roos, R. (author), Van Steenbergen, M.J. (author), Kaaijk, C.N.J. (author), Koster-Ammerlaan, M.J.J. (author), De Leege, P.F.A. (author), Hennink, W.E. (author), Van het Schip, A.D. (author), Krijger, G.C. (author)
Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (166Ho-PLLA-MS) are a novel microdevice for intra-arterial radioembolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the 166Ho-PLLA-MS. The degree of damage is dependent on the...
journal article 2009
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Bult, W. (author), Seevinck, P.R. (author), Krijger, G.C. (author), Visser, T. (author), Kroon-Batenburg, L.M.J. (author), Bakker, C.J.G. (author), Hennink, W.E. (author), Van het Schip, A.D. (author), Nijsen, J.F.W. (author)
Purpose The aim of this study was to develop microspheres with an ultra high holmium content which can be neutron activated for radioablation of malignancies. These microspheres are proposed to be delivered selectively through either intratumoral injections into solid tumors or administered via an intravascularly placed catheter. Methods...
journal article