Searched for: author%3A%22Laan%2C+L.%22
(1 - 12 of 12)
document
Glazenburg, M.M. (author), Laan, L. (author)
Cellular life exhibits order and complexity, which typically increase over the course of evolution. Cell polarization is a well-studied example of an ordering process that breaks the internal symmetry of a cell by establishing a preferential axis. Like many cellular processes, polarization is driven by self-organization, meaning that the...
review 2023
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Daalman, W.K. (author), Sweep, E. (author), Laan, L. (author)
Accurate phenotype prediction based on genetic information has numerous societal applications, such as crop design or cellular factories. Epistasis, when biological components interact, complicates modelling phenotypes from genotypes. Here we show an approach to mitigate this complication for polarity establishment in budding yeast, where...
journal article 2023
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Brauns, Fridtjof (author), Iñigo de la Cruz, L.M. (author), Daalman, W.K. (author), de Bruin, Ilse (author), Halatek, Jacob (author), Laan, L. (author), Frey, Erwin (author)
How can a self-organized cellular function evolve, adapt to perturbations, and acquire new sub-functions? To make progress in answering these basic questions of evolutionary cell biology, we analyze, as a concrete example, the cell polarity machinery of Saccharomyces cerevisiae. This cellular module exhibits an intriguing resilience: it...
journal article 2023
document
Kingma, E. (author), Diepeveen, E.T. (author), Iñigo de la Cruz, L.M. (author), Laan, L. (author)
The ability of cells to translate different extracellular cues into different intracellular responses is vital for their survival in unpredictable environments. In Saccharomyces cerevisiae, cell polarity is modulated in response to environmental signals which allows cells to adopt varying morphologies in different external conditions. The...
journal article 2023
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Zwicker, David (author), Laan, L. (author)
Phase separation has emerged as an essential concept for the spatial organization inside biological cells. However, despite the clear relevance to virtually all physiological functions, we understand surprisingly little about what phases form in a system of many interacting components, like in cells. Here we introduce a numerical method based...
journal article 2022
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Wortel, Meike T. (author), Agashe, Deepa (author), Bailey, Susan F. (author), Bank, Claudia (author), Bisschop, Karen (author), Blankers, Thomas (author), Laan, L. (author), Meijer, Jeroen (author), Tans, S.J. (author)
Evolution has traditionally been a historical and descriptive science, and predicting future evolutionary processes has long been considered impossible. However, evolutionary predictions are increasingly being developed and used in medicine, agriculture, biotechnology and conservation biology. Evolutionary predictions may be used for...
review 2022
document
Linne, C. (author), Visco, Daniele (author), Angioletti-Uberti, Stefano (author), Laan, L. (author), Kraft, Daniela J. (author)
Reliably distinguishing between cells based on minute differences in receptor density is crucial for cell-cell or virus-cell recognition, the initiation of signal transduction, and selective targeting in directed drug delivery. Such sharp differentiation between different surfaces based on their receptor density can only be achieved by...
journal article 2021
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Daalman, W.K. (author), Sweep, E. (author), Laan, L. (author)
A bottom-up route towards predicting evolution relies on a deep understanding of the complex network that proteins form inside cells. In a rapidly expanding panorama of experimental possibilities, the most difficult question is how to conceptually approach the disentangling of such complex networks. These can exhibit varying degrees of...
review 2020
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Vendel, K.J.A. (author), Tschirpke, S. (author), Shamsi, F. (author), Dogterom, A.M. (author), Laan, L. (author)
Cell polarity - the morphological and functional differentiation of cellular compartments in a directional manner - is required for processes such as orientation of cell division, directed cellular growth and motility. How the interplay of components within the complexity of a cell leads to cell polarity is still heavily debated. In this...
review 2019
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Jelenic, Ivan (author), Selmecki, Anna (author), Laan, L. (author), Pavin, Nenad (author)
Faithful chromosome segregation, driven by the mitotic spindle, is essential for organismal survival. Neopolyploid cells from diverse species exhibit a significant increase in mitotic errors relative to their diploid progenitors, resulting in chromosome nondisjunction. In the model system Saccharomyces cerevisiae, the rate of chromosome loss...
journal article 2018
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Diepeveen, E.T. (author), Iñigo de la Cruz, L.M. (author), Laan, L. (author)
Polarity establishment underlies proper cell cycle completion across virtually all organisms. Much progress has been made in generating an understanding of the structural and functional components of this process, especially in model species. Here we focus on the evolutionary dynamics of the fungal polarization protein network in order to...
review 2017
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Van der Knaap, G.A. (author), Van der Laan, L. (author)
Deze voorstudie is in opdracht van het Programmeringsoverleg Ruimtelijk Onderzoek (PRO) geschreven door prof dr. G.A. van der Knaap en dr. L. van der Laan van de Erasmus Universiteit Rotterdam. Op basis van een analyse van relevante maatschappelijke en beleidsontwikkelingen, voortvloeiend uit met name een verkenning van een drietal megatrends en...
book 1991
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