Searched for: author:"Lelieveldt, B.P.F."
(1 - 20 of 34)

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Shahzad, Rahil (author), Shankar, A (author), Amier, Raquel (author), Nijveldt, Robin (author), Westenberg, Jos J.M. (author), de Roos, Albert (author), Lelieveldt, B.P.F. (author), van der Geest, R.J. (author)
Background: Aortic pulse wave velocity (PWV) is an indicator of aortic stiffness and is used as a predictor of adverse cardiovascular events. PWV can be non-invasively assessed using magnetic resonance imaging (MRI). PWV computation requires two components, the length of the aortic arch and the time taken for the systolic pressure wave to...
journal article 2019
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Abdelmoula, Walid M. (author), Pezzotti, N. (author), Hollt, T. (author), Dijkstra, J (author), Vilanova Bartroli, A. (author), McDonnell, Liam A. (author), Lelieveldt, B.P.F. (author)
Technological advances in mass spectrometry imaging (MSI) have contributed to growing interest in 3D MSI. However, the large size of 3D MSI data sets has made their efficient analysis and visualization and the identification of informative molecular patterns computationally challenging. Hierarchical stochastic neighbor embedding (HSNE), a...
journal article 2018
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Liu, Shengnan (author), Dzyubachyk, Oleh (author), Eggermont, Jeroen (author), Nakatani, Shimpei (author), Lelieveldt, B.P.F. (author), Dijkstra, J. (author)
Purpose: Intravascular optical coherence tomography (OCT) is widely used for analysis of the coronary artery disease. Its high spatial resolution allows for visualization of arterial tissue components in detail. There are different OCT systems on the market, each of which produces data characterized by its own intensity range and distribution...
journal article 2018
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Sun, Zhuo (author), Qiao, Yuchuan (author), Lelieveldt, B.P.F. (author), Staring, M. (author)
In recent years, machine learning approaches have been successfully applied to the field of neuroimaging for classification and regression tasks. However, many approaches do not give an intuitive relation between the raw features and the diagnosis. Therefore, they are difficult for clinicians to interpret. Moreover, most approaches treat the...
journal article 2018
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Li, Na (author), van Unen, V. (author), Hollt, T. (author), Thompson, Allan (author), van Bergen, Jeroen (author), Pezzotti, N. (author), Eisemann, E. (author), Vilanova Bartroli, A. (author), Chuva de Sousa Lopes, S.M. (author), Lelieveldt, B.P.F. (author), Koning, F. (author)
Innate lymphoid cells (ILCs) are abundant in mucosal tissues and involved in tissue homeostasis and barrier function. Although several ILC subsets have been identified, it is unknown if additional heterogeneity exists, and their differentiation pathways remain largely unclear. We applied mass cytometry to analyze ILCs in the human fetal...
journal article 2018
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Aizenberg, Evgeni (author), Roex, Edgar A.H. (author), Nieuwenhuis, Wouter P. (author), Mangnus, Lukas (author), van der Helm-Mil, Annette H.M. (author), Reijnierse, Monique (author), Bloem, Johan L. (author), Lelieveldt, B.P.F. (author), Stoel, Berend G. (author)
Methods: For 485 early arthritis patients (clinically confirmed arthritis of one or more joints, symptoms for less than 2 years), MR scans of the wrist were processed in three...
journal article 2018
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Pezzotti, N. (author), Hollt, T. (author), van Gemert, J.C. (author), Lelieveldt, B.P.F. (author), Eisemann, E. (author), Vilanova Bartroli, A. (author)
Deep neural networks are now rivaling human accuracy in several pattern recognition problems. Compared to traditional classifiers, where features are handcrafted, neural networks learn increasingly complex features directly from the data. Instead of handcrafting the features, it is now the network architecture that is manually engineered. The...
journal article 2018
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Laban, Sandra (author), Suwandi, Jessica S. (author), van Unen, V. (author), Pool, J (author), Wesselius, Joris (author), Hollt, T. (author), Pezzotti, N. (author), Vilanova Bartroli, A. (author), Lelieveldt, B.P.F. (author), Roep, Bart O. (author)
Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these auto-reactive cytolytic CD8 T-cells has not yet been extensively described. We used high-dimensional mass cytometry to phenotype autoantigen- (pre-proinsulin), neoantigen- (insulin-DRIP)...
journal article 2018
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Sun, Zhuo (author), van de Giessen, M. (author), Lelieveldt, B.P.F. (author), Staring, M. (author)
Mild Cognitive Impairment (MCI) is an intermediate stage between healthy and Alzheimer’s disease (AD). To enable early intervention it is important to identify the MCI subjects that will convert to AD in an early stage. In this paper, we provide a new method to distinguish between MCI patients that either convert to Alzheimer’s Disease (MCIc)...
journal article 2017
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Dzyubachyk, Oleh (author), Staring, M. (author), Reijnierse, Monique (author), Lelieveldt, B.P.F. (author), van der Geest, Rob J. (author)
Purpose To develop and validate a method for performing inter-station intensity standardization in multispectral whole-body MR data. Methods Different approaches for mapping the intensity of each acquired image stack into the reference intensity space were developed and validated. The registration strategies included: “direct” registration to...
journal article 2017
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Liu, Shengnan (author), Sotomi, Yohei (author), Eggermont, Jeroen (author), Nakazawa, Gaku (author), Torii, Sho (author), Ijichi, Takeshi (author), Onuma, Yoshinobu (author), Serruys, Patrick W. (author), Lelieveldt, B.P.F. (author), Dijkstra, J. (author)
An important application of intravascular optical coherence tomography (IVOCT) for atherosclerotic tissue analysis is using it to estimate attenuation and backscatter coefficients. This work aims at exploring the potential of the attenuation coefficient, a proposed backscatter term, and image intensities in distinguishing different...
journal article 2017
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Aizenberg, Evgeni (author), van den Berg, Rosaline (author), Ez-Zaitouni, Zineb (author), van der Heijde, Désirée (author), Reijnierse, Monique (author), Dzyubachyk, Oleh (author), Lelieveldt, B.P.F. (author)
Background: Evaluating inflammatory changes over time on MR images of the spine in patients with suspected axial Spondyloarthritis (axSpA) can be a labor-intensive task, requiring readers to manually search for and perceptually align a set of vertebrae between two scans. The purpose of this study was to assess the feasibility of computer...
journal article 2017
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van Unen, V. (author), Hollt, T. (author), Pezzotti, N. (author), Li, Na (author), Reinders, M.J.T. (author), Eisemann, E. (author), Koning, F. (author), Vilanova Bartroli, A. (author), Lelieveldt, B.P.F. (author)
Mass cytometry allows high-resolution dissection of the cellular composition of the immune system. However, the high-dimensionality, large size, and non-linear structure of the data poses considerable challenges for the data analysis. In particular, dimensionality reduction-based techniques like t-SNE offer single-cell resolution but are...
journal article 2017
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Keo, D.L. (author), Aziz, N. Ahmad (author), Dzyubachyk, Oleh (author), Van Der Grond, Jeroen (author), van Roon-Mom, WMC (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)
Cytosine-adenine-guanine (CAG) repeat expansions in the coding regions of nine polyglutamine (polyQ) genes (HTT, ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, ATN1, AR, and TBP) are the cause of several neurodegenerative diseases including Huntington’s disease (HD), six different spinocerebellar ataxias (SCAs), dentatorubral-pallidoluysian atrophy, and...
journal article 2017
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Doorenweerd, Nathalie (author), Mahfouz, A.M.E.T.A. (author), van Putten, Maaike (author), Kaliyaperumal, Rajaram (author), 't Hoen, P.A.C. (author), Hendriksen, Jos G.M. (author), Aartsma-Rus, Annemieke M. (author), Verschuuren, Jan J.G.M. (author), Niks, Erik H. (author), Reinders, M.J.T. (author), Kan, Hermien E. (author), Lelieveldt, B.P.F. (author)
Duchenne muscular dystrophy (DMD) is a muscular dystrophy with high incidence of learning and behavioural problems and is associated with neurodevelopmental disorders. To gain more insights into the role of dystrophin in this cognitive phenotype, we performed a comprehensive analysis of the expression patterns of dystrophin isoforms across...
journal article 2017
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Mulder, Inge A. (author), Khmelinskii, Artem (author), Dzyubachyk, Oleh (author), de Jong, Sebastiaan (author), Rieff, Nathalie (author), Wermer, Marieke J.H. (author), Hoehn, Mathias (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author)
Magnetic resonance imaging (MRI) has become increasingly important in ischemic stroke experiments in mice, especially because it enables longitudinal studies. Still, quantitative analysis of MRI data remains challenging mainly because segmentation of mouse brain lesions in MRI data heavily relies on time-consuming manual tracing and...
journal article 2017
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Mulder, Inge A. (author), Khmelinskii, Artem (author), Dzyubachyk, Oleh (author), De Jong, Sebastiaan (author), Wermer, Marieke J.H. (author), Hoehn, Mathias (author), Lelieveldt, B.P.F. (author), van den Maagdenberg, Arn M.J.M. (author)
In this data report we make available to the community a highly variable longitudinal MRI mouse brain data set of ischemic lesion after transient middle cerebral artery occlusion (tMCAo). Together with the provided semi-automated and automated segmentations, these data can be used to further improve the method proposed by Mulder et al. (2017)...
journal article 2017
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Mahfouz, A.M.E.T.A. (author), Huisman, S.M.H. (author), Lelieveldt, B.P.F. (author), Reinders, M.J.T. (author)
The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms...
journal article 2017
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Huisman, S.M.H. (author), Van Lew, B. (author), Mahfouz, A.M.E.T.A. (author), Pezzotti, N. (author), Hollt, T. (author), Michielsen, Lieke C.M. (author), Vilanova Bartroli, A. (author), Reinders, M.J.T. (author), Lelieveldt, B.P.F. (author)
Spatial and temporal brain transcriptomics has recently emerged as an invaluable data source for molecular neuroscience. The complexity of such data poses considerable challenges for analysis and visualization. We present BrainScope: A web portal for fast, interactive visual exploration of the Allen Atlases of the adult and developing human...
journal article 2017
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Elbaz, MSM (author), van der Geest, Rob J. (author), Calkoen, EE (author), de Roos, A. (author), Lelieveldt, B.P.F. (author), Roest, AAW (author), Westenberg, JJM (author)
Purpose To evaluate viscous energy loss and the association with three-dimensional (3D) vortex ring formation in left ventricular (LV) blood flow during diastolic filling. Theory and Methods Thirty healthy volunteers were compared with 32 patients with corrected atrioventricular septal defect as unnatural mitral valve morphology and inflow are...
journal article 2017
Searched for: author:"Lelieveldt, B.P.F."
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