Searched for: author%3A%22Lips%2C+E.H.%22
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Schouten, P.C. (author), Grigoriadis, A. (author), Kuilman, T. (author), Mirza, H. (author), Watkins, J.A. (author), Cooke, S.A. (author), Van Dyk, E. (author), Severson, T.M. (author), Rueda, O.M. (author), Hoogstraat, M. (author), Verhagen, C. (author), Natrajan, R. (author), Chin, S.F. (author), Lips, E.H. (author), Kruizinga, J. (author), Velds, A. (author), Nieuwland, M. (author), Kerkhoven, R.M. (author), Krijgsman, O. (author), Vens, C. (author), Peeper, D. (author), Nederlof, P.M. (author), Caldas, C. (author), Tutt, A.N. (author), Wessels, L.F.A. (author), Linn, S.C. (author)
Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1-like’ or ‘non-BRCA1-like’, which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approximately one third of the BRCA1-like breast...
journal article 2015
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Vollebergh, M.A. (author), Lips, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Wesseling, J. (author), Van de Vijver, M.J. (author), De vries, E.G.E. (author), Van Tinteren, H. (author), Jonkers, J. (author), Hauptman, M. (author), Rodenhuis, S. (author), Linn, S.C. (author)
Introduction: BRCA-mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating agents and platinum salts. HRD can be caused...
journal article 2014
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De Ronde, J.J. (author), Bonder, M.J. (author), Lips, E.H. (author), Rodenhuis, S. (author), Wessels, L.F.A. (author)
Introduction: Despite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has become clear in recent years that breast cancer is a collection of molecularly distinct diseases. With ever increasing amounts of breast cancer data becoming available, we set out to study if...
journal article 2014