- document
-
Baglioni, G. (author), Pezone, R. (author), Vollebregt, S. (author), Cvetanović Zobenica, Katarina (author), Spasenović, Marko (author), Todorović, Dejan (author), Liu, H. (author), Verbiest, G.J. (author), van der Zant, H.S.J. (author), Steeneken, P.G. (author)Microphones exploit the motion of suspended membranes to detect sound waves. Since the microphone performance can be improved by reducing the thickness and mass of its sensing membrane, graphene-based microphones are expected to outperform state-of-the-art microelectromechanical (MEMS) microphones and allow further miniaturization of the...journal article 2023
- document
-
Liu, H. (author), Nadar, R.A. (author), Fauzia, R.P. (author), Laan, A.C. (author), Wang, R. (author), van Cooten, Quenteijn (author), Carroll, E.C.M. (author), Eelkema, R. (author), Denkova, A.G. (author)Combination of therapies is a common strategy in cancer treatment. Such combined therapies only have merit provided that there is superior therapeutic outcome with fewer side effects, compared to single therapies. Here, this work explores the possibility to combine chemotherapy with radionuclide therapy using polymeric micelles as a delivery...journal article 2023
- document
-
Sarafraz, A. (author), Givois, A.P.P. (author), Roslon, I.E. (author), Liu, H. (author), Brahmi, Hatem (author), Verbiest, G.J. (author), Steeneken, P.G. (author), Alijani, F. (author)The resonance frequency of ultra-thin layered nanomaterials changes nonlinearly with the tension induced by the pressure from the surrounding gas. Although the dynamics of pressurized nanomaterial membranes have been extensively explored, recent experimental observations show significant deviations from analytical predictions. Here, we...journal article 2023
- document
-
Liu, H. (author), Lee, M. (author), Siskins, M. (author), van der Zant, H.S.J. (author), Steeneken, P.G. (author), Verbiest, G.J. (author)Heat transport by acoustic phonons in two-dimensional (2D) materials is fundamentally different from that in 3D crystals because the out-of-plane phonons propagate in a unique way that strongly depends on tension and bending rigidity. Here, using optomechanical techniques, we experimentally demonstrate that the heat transport time in...journal article 2023
- document
-
Liu, H. (author), Basuvalingam, Saravana B. (author), Lodha, S.V. (author), Bol, Ageeth A. (author), van der Zant, H.S.J. (author), Steeneken, P.G. (author), Verbiest, G.J. (author)Atomic layer deposition (ALD), a layer-by-layer controlled method to synthesize ultrathin materials, provides various merits over other techniques such as precise thickness control, large area scalability and excellent conformality. Here we demonstrate the possibility of using ALD growth on top of suspended 2D materials to fabricate...journal article 2023
- document
-
Liu, H. (author)In the Geomatics domain, a point cloud refers to a data set which records the coordinates and other attributes of a huge number of points. Conceptually, each of these attributes can be regarded as a dimension, representing a specific type of information. Apart from routinely concerned spatio-temporal dimensions for coordinates, other dimensions...doctoral thesis 2022
- document
-
Piergentili, I. (author), Bouwmans, Pepijn R. (author), Reinalda, L. (author), Lewis, R.W. (author), Klemm, Benjamin (author), Liu, H. (author), de Kruijff, R.M. (author), Denkova, A.G. (author), Eelkema, R. (author)In certain tumor and diseased tissues, reactive oxygen species (ROS), such as H<sub>2</sub>O<sub>2</sub>, are produced in higher concentrations than in healthy cells. Drug delivery and release systems that respond selectively to the presence of ROS, while maintaining their stability in “healthy” biological conditions, have great potential as...journal article 2022
- document
-
Liu, H. (author), de Kruijff, R.M. (author), Laan, A.C. (author), Beekman, F.J. (author), van den Heuvel, E.J. (author), Ramakers, R.M. (author), Eelkema, R. (author), Denkova, A.G. (author)A variety of polymer micelles are designed for the delivery of chemotherapeutic drugs to tumors. Although the promise of these nanocarriers is very high, in the clinic the effectivity is rather limited. Determining the in vivo fate of the micelles can greatly help to improve this treatment. Here, a simple and fast chelator-free method for...journal article 2022
- document
-
Ma, C. (author), Liu, H. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Four different MOFs were exposed to γrays by a cobalt-60 source reaching a maximum dose of 5 MGy. The results showed that the MIL-100 (Cr) and MIL-100 (Fe) did not exhibit obvious structural damage, suggesting their excellent radiation stability. MIL-101 (Cr) showed good radiation stability up to 4 MGy, but its structure started degrading...journal article 2022
- document
-
Diaz, Vitali (author), Liu, H. (author), van Oosterom, P.J.M. (author), Meijers, B.M. (author), Verbree, E. (author), Baart, F. (author), Pronk, M.J. (author), Van Lankveld, T. (author)Point cloud is made up of a multitude of three-dimensional (3D) points with one or more attributes attached. Point cloud is the third data paradigm in addition to the well-established object (vector) and gridded (raster) representations, since point cloud data can be directly collected, computed, stored, and analyzed without converting to other...conference paper 2022
- document
-
Liu, H. (author)The focus of this thesis is on the utilization of biodegradable drug nanocarriers combined with ionizing radiation in cancer treatment. Polymeric micelles based on PCL-PEO block copolymers were selected as the main platform for delivering various therapeutic substances due to their size, degradability and easy preparation. This thesis can...doctoral thesis 2021
- document
-
Liu, H. (author), Thompson, R.J. (author), van Oosterom, P.J.M. (author), Meijers, B.M. (author)Efficient spatial queries are frequently needed to extract useful information from massive nD point clouds. Most previous studies focus on developing solutions for orthogonal window queries, while rarely considering the polytope query. The latter query, which includes the widely adopted polygonal query in 2D, also plays a critical role in...journal article 2021
- document
-
Liu, H. (author), van Oosterom, P.J.M. (author), Mao, B. (author), Meijers, B.M. (author), Thompson, R. (author)Governments use flood maps for city planning and disaster management to protect people and assets. Flood risk mapping projects carried out for these purposes generate a huge amount of modelling results. Previously, data submitted are highly condensed products such as typical flood inundation maps and tables for loss analysis. Original...journal article 2021
- document
-
Liu, H. (author), Thompson, R.J. (author), van Oosterom, P.J.M. (author), Meijers, B.M. (author)As an extension to 2D polygonal queries, the nD-polytope queries on point clouds also play a crucial rolein nD GIS applications such as the perspective view selection. This report rst denes the nD-polytopemathematically, and then develops an ecient nD-polytope querying solution by extending an index-organized table (IOT) approach. The solution...report 2021
- document
-
Men, Y. (author), Breve, T. (author), Liu, H. (author), Denkova, A.G. (author), Eelkema, R. (author)We present a new light cleavable polymer containing o-nitrobenzene thioacetal groups in the main chain. By conjugation to a PEG block, we synthesized block copolymers capable of forming nanoparticles in aqueous solution. We studied drug encapsulation and release using the model drug Nile Red. Irradiation with UV-A light (365 nm) leads to...journal article 2021
- document
-
Liu, H. (author), Kementzetzidis, E. (author), Abell, J. A. (author), Pisano, F. (author)Serviceability criteria for offshore monopiles include the estimation of long-term, permanent tilt under repeated operational loads. In the lack of well-established analysis methods, experimental and numerical research has been carried out in the last decade to support the fundamental understanding of monopile-soil interaction mechanisms, and...journal article 2021
- document
-
Liu, H. (author), Laan, A.C. (author), Plomp, J. (author), Parnell, S.R. (author), Men, Y. (author), Dalgliesh, Robert M. (author), Eelkema, R. (author), Denkova, A.G. (author)Polymeric micelles, due to their easy preparation and versatile properties, have been widely applied as one of the most popular carriers for chemotherapeutic agents. Such micelles primarily prevent the leakage of drugs during transportation and thus protect healthy tissue. Controlled drug release, which releases the drugs at the site of...journal article 2021
- document
-
Cheng, Xiaoyang (author), Diambra, Andrea (author), Ibraim, Erdin (author), Liu, H. (author), Pisano, F. (author)Based on advanced 3D finite element modelling, this paper analyses the stress paths experienced by soil elements in the vicinity of a monopile foundation for offshore wind turbines subjected to cyclic loading with the aim of informing soil laboratory testing in support of monopile foundation design. It is shown that the soil elements in front of...journal article 2021
- document
-
Liu, Chenxi (author), Xu, Yanlin (author), Liu, H. (author), Lin, Mingtuan (author), Zha, Song (author)A terahertz metamaterial with switching characteristics from optical buffering to absorbing performance is realized by incorporating a phase-change film of vanadium dioxide. By introducing the electromagnetically induced transparency behavior based on simple strip pairs, the slow light effect with group delay up to 3.5 ps is obtained. When...journal article 2021
- document
-
Breve, T. (author), Liu, H. (author), Denkova, A.G. (author), Eelkema, R. (author)Gamma radiation triggered secondary crosslinking of dextran hydrogels leads to macroscopic hydrogel contraction. The authors use stable polymer hydrogels, prepared through azide-alkyne crosslinking, containing surplus alkyne groups. γ-irradiation of these gels leads to more alkyne crosslinking, enabling controlled increase of crosslink...journal article 2021