Searched for: author:"Meulenbelt, I."
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Bomer, N. (author), Den Hollander, W.T.H.F. (author), Ramos, Y.F.M. (author), Bos, S.D. (author), Van der Breggen, R. (author), Lakenberg, N. (author), Pepers, B.A. (author), Van Eeden, A.E. (author), Darvishan, A. (author), Tobi, E.W. (author), Duijnisveld, B.J. (author), Van den Akker, E.B. (author), Heijmans, B.T. (author), Van Roon-Mom, W.M.C. (author), Verbeek, F.J. (author), Osch, G.J.V.M. (author), Nelissen, R.G.H.H. (author), Slagboom, P.E. (author), Meulenbelt, I. (author)
Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG...
journal article 2015
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Slieker, R.C. (author), Bos, S.D. (author), Goeman, J.J. (author), Bovee, J.V.M.G. (author), Talens, R.P. (author), Van der Breggen, R. (author), Suchiman, H.E.D. (author), Lameijer, E.W. (author), Putter, H. (author), Van dern Akker, E.B. (author), Zhang, Y. (author), Jukema, J.W. (author), Slagboom, P.E. (author), Meulenbelt, I. (author), Heijmans, B.T. (author)
Background: DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study design and focus there still is no consensus as to the annotation of genomic regions predominantly involved in tissue-specific...
journal article 2013