Searched for: author%3A%22Nederlof%2C+P.M.%22
(1 - 5 of 5)
document
Schouten, P.C. (author), Grigoriadis, A. (author), Kuilman, T. (author), Mirza, H. (author), Watkins, J.A. (author), Cooke, S.A. (author), Van Dyk, E. (author), Severson, T.M. (author), Rueda, O.M. (author), Hoogstraat, M. (author), Verhagen, C. (author), Natrajan, R. (author), Chin, S.F. (author), Lips, E.H. (author), Kruizinga, J. (author), Velds, A. (author), Nieuwland, M. (author), Kerkhoven, R.M. (author), Krijgsman, O. (author), Vens, C. (author), Peeper, D. (author), Nederlof, P.M. (author), Caldas, C. (author), Tutt, A.N. (author), Wessels, L.F.A. (author), Linn, S.C. (author)
Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1-like’ or ‘non-BRCA1-like’, which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approximately one third of the BRCA1-like breast...
journal article 2015
document
Vollebergh, M.A. (author), Lips, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Wesseling, J. (author), Van de Vijver, M.J. (author), De vries, E.G.E. (author), Van Tinteren, H. (author), Jonkers, J. (author), Hauptman, M. (author), Rodenhuis, S. (author), Linn, S.C. (author)
Introduction: BRCA-mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating agents and platinum salts. HRD can be caused...
journal article 2014
document
Holstege, H. (author), Van Beers, E. (author), Velds, A. (author), Liu, X. (author), Joosse, S.A. (author), Klarenbeek, S. (author), Schut, E. (author), Kerkhoven, R. (author), Klijn, C.N. (author), Wessels, L.F.A. (author), Nederlof, P.M. (author), Jonkers, J. (author)
Background: Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor genes whose absence or overexpression may give...
journal article 2010
document
Lai, C. (author), Horlings, H.M. (author), Van De Vijver, M.J. (author), Van Beers, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Reinders, M.J.T. (author)
journal article 2007
document
Nederlof, P.M. (author), Van Beers, E. (author), Joosse, S. (author), Hogervorst, F.B.L. (author), Wessels, L.F.A. (author), Devilee, P. (author), Cornelisse, C. (author), Oldenburg, R. (author), Verhoef, S. (author), Van 't Veer, L.J. (author)
journal article 2005
Searched for: author%3A%22Nederlof%2C+P.M.%22
(1 - 5 of 5)