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Coutinho de Almeida, Rodrigo (author), Mahfouz, A.M.E.T.A. (author), Mei, Hailiang (author), Houtman, Evelyn (author), den Hollander, Wouter (author), Soul, Jamie (author), Suchiman, Eka (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author)OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which...journal article 2021
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van der Voort, Paul (author), van Delft, Danny (author), Valstar, E.R. (author), Kaptein, B.L. (author), Fiocco, Marta (author), Nelissen, R.G.H.H. (author)Introduction: Excellent long-term survival has been reported for both the Taperloc and the Mallory-Head cementless stems. However, little is known about the migration behaviour of these stems which have different design rationales. The purpose of this randomised clinical trial was to compare the migration and clinical outcomes of these stems...journal article 2021
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Van Der Voort, Paul (author), D Klein Nulent, Martijn L. (author), Valstar, E.R. (author), Kaptein, B.L. (author), Fiocco, Marta (author), Nelissen, R.G.H.H. (author)Background and purpose — Little is known about the long-term migration pattern of cementless stems in total hip arthroplasty (THA). Furthermore, the role of bioactive coatings in fixation, and thus migration, remains uncertain. Hydroxyapatite (HA) is the most commonly used bioactive coating. However, delamination of the coating might induce...journal article 2020
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Kraaij, G. (author), Loeve, A.J. (author), Dankelman, J. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author)Mechanical loosening of implants is in the majority accompanied with a periprosthetic interface membrane, which has to be removed during revision surgery. The same is true if a minimal invasive (percutaneous) refixation of a loose implant is done. We describe the requirements for a waterjet applicator for interface tissue removal for this...journal article 2019
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Willemsen, K. (author), Berendes, Thomas D. (author), Geurkink, Timon (author), Bleys, Ronald L.A.W. (author), Leeflang, M.A. (author), Weinans, H.H. (author), Castelein, René M. (author), Nelissen, R.G.H.H. (author), van der Wal, Bart C.H. (author)BACKGROUND: Anterior glenohumeral instability with >20% glenoid bone loss is a disorder that can be treated with the Latarjet stabilizing procedure; however, complications are common. The purposes of this study were to (1) evaluate the effect of an anatomic-specific titanium implant produced by 3-dimensional (3D) printing as a treatment...journal article 2019
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Coutinho de Almeida, Rodrigo (author), Ramos, Yolande F.M. (author), Mahfouz, A.M.E.T.A. (author), den Hollander, Wouter (author), Lakenberg, Nico (author), Houtman, Evelyn (author), van Hoolwerff, Marcella (author), Suchiman, H. Eka D. (author), Rodriguez-Ruiz, Alejandro (author), Slagboom, P. Eline (author), Mei, Hailiang (author), Kielbasa, Szymon M. (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author), Meulenbelt, Ingrid (author)Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage.<br/>Methods We performed RNA sequencing in 130 samples (n=35 and n=30 pairs for messenger RNA (mRNA) and miRNA, respectively) on macroscopically preserved and lesioned OA cartilage from the same patient and performed...journal article 2018
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Van Hamersveld, Koen T. (author), Marang-Van De Mheen, Perla J. (author), Van Der Heide, Huub J.L. (author), Van Der Linden-Van Der Zwaag, Henrica M.J. (author), Valstar, E.R. (author), Nelissen, R.G.H.H. (author)Background and purpose — Mobile-bearing total knee prostheses (TKPs) were developed in the 1970s in an attempt to increase function and improve implant longevity. However, modern fixed-bearing designs like the single-radius TKP may provide similar advantages. We compared tibial component migration measured with radiostereometric analysis (RSA...journal article 2018
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- Nelissen, R.G.H.H. (author), Kaptein, B.L. (author), Veeger, H.E.J. (author) journal article 2017
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Peri-prosthetic tissue cells show osteogenic capacity to differentiate into the osteoblastic lineageSchoeman, Monique A.E. (author), Oostlander, Angela E. (author), Rooij, Karien Ede (author), Valstar, E.R. (author), Nelissen, R.G.H.H. (author)During the process of aseptic loosening of prostheses, particulate wear debris induces a continuous inflammatory-like response resulting in the formation of a layer of fibrous peri-prosthetic tissue at the bone-prosthesis interface. The current treatment for loosening is revision surgery which is associated with a high-morbidity rate,...journal article 2017
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Meinardi, J.E. (author), Valstar, E.R. (author), van der Voort, P (author), Kaptein, B.L. (author), Fiocco, M. (author), Nelissen, R.G.H.H. (author)Background and purpose — Stability and survival of cemented total hip prostheses is dependent on a multitude of factors, including the type of cement that is used. Bone cements vary in viscosity, from low to medium and high. There have been few clinical RSA studies comparing the performance of low- and high-viscosity bone cements. We compared...journal article 2016
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Bomer, N. (author), Den Hollander, W.T.H.F. (author), Ramos, Y.F.M. (author), Bos, S.D. (author), Van der Breggen, R. (author), Lakenberg, N. (author), Pepers, B.A. (author), Van Eeden, A.E. (author), Darvishan, A. (author), Tobi, E.W. (author), Duijnisveld, B.J. (author), Van den Akker, E.B. (author), Heijmans, B.T. (author), Van Roon-Mom, W.M.C. (author), Verbeek, F.J. (author), Osch, G.J.V.M. (author), Nelissen, R.G.H.H. (author), Slagboom, P.E. (author), Meulenbelt, I. (author)Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG...journal article 2015
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Malan, D.F. (author), Van der Walt, S.J. (author), Raidou, R.G. (author), Van den Berg, B. (author), Stoel, B.C. (author), Botha, C.P. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author)Purpose In orthopaedics, minimally invasive injection of bone cement is an established technique. We present HipRFX, a software tool for planning and guiding a cement injection procedure for stabilizing a loosening hip prosthesis. HipRFX works by analysing a pre-operative CT and intraoperative C-arm fluoroscopic images. Methods HipRFX simulates...journal article 2015
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Van der Voort, P. (author), Pijls, B.G. (author), Nieuwenhuijse, M.J. (author), Jasper, J. (author), Fiocco, M. (author), Plevier, J.W.M. (author), Middeldorp, S. (author), Valstar, E.R. (author), Nelissen, R.G.H.H. (author)Background and purpose — Few studies have addressed the association between early migration of femoral stems and late aseptic revision in total hip arthroplasty. We performed a meta-regression analysis on 2 parallel systematic reviews and meta-analyses to determine the association between early migration and late aseptic revision of femoral...journal article 2015
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Andreykiv, A. (author), Janssen, D. (author), Nelissen, R.G.H.H. (author), Vlastar, E.R. (author)Background Cement injection into osteolytic areas around the cement mantle is a technique for refixation of loose hip implants for patients who cannot undergo standard revision surgery. Preliminary clinical results show the improvement in walking distance, patients' independence and pain relief. Methods In this study, we use a detailed finite...journal article 2012
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Wolterbeek, N. (author), Garling, E.H. (author), Mertens, B.J. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author)Background The mobile-bearing variant of a single-radius design is assumed to provide more freedom of motion compared to the fixed-bearing variant because the insert does not restrict the natural movements of the femoral component. This would reduce the contact stresses and wear which in turn may have a positive effect on the fixation of the...journal article 2012
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Pijls, B.G. (author), Dekkers, O.M. (author), Middeldorp, S. (author), Valstar, E.R. (author), Van der Heide, H.J.L. (author), Van der Linden-Van der Zwaag, H.M.J. (author), Nelissen, R.G.H.H. (author)Background: In the light of both the importance and large numbers of case series and cohort studies (observational studies) in orthopaedic literature, it is remarkable that there is currently no validated measurement tool to appraise their quality. A Delphi approach was used to develop a checklist for reporting quality, methodological quality...journal article 2011
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Wolterbeek, N. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author)Purpose: The aim of this study was to compare a broad range of total knee prostheses with different design parameters to determine whether in vivo kinematics was consistently related to design. The hypothesis was that there are no clear recognizable differences in in vivo kinematics between different design parameters or prostheses. Methods: At...journal article 2011
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Malan, D.F. (author), Botha, C.P. (author), Kraaij, G. (author), Joemai, R.M.S. (author), Van der Heide, H.J.L. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author)Objective Computed tomography is the modality of choice for measuring osteolysis but suffers from metal-induced artefacts obscuring periprosthetic tissues. Previous papers on metal artefact reduction (MAR) show qualitative improvements, but their algorithms have not found acceptance for clinical applications. We investigated to what extent metal...journal article 2011
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Krekel, P.R. (author), Vochteloo, A.J.H. (author), Bloem, R.M. (author), Nelissen, R.G.H.H. (author)Introduction :Femoroacetabular impingement leads to limited hip motion, pain and progressive damage to the labrum. Assessment of the amount and location of excessive ossification can be difficult, and removal does not always lead to pain relief and an increase of function. One of the challenges ahead is to discover why certain cases have poor...journal article 2011
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Garling, E.H. (author), Wolterbeek, N. (author), Velzeboer, S. (author), Nelissen, R.G.H.H. (author), Valstar, E.R. (author), Doorenbosch, C.A.M. (author), Harlaar, J. (author)It was hypothesized that rheumatoid arthritis (RA) patients with a total knee prosthesis that allows axial rotation of the bearing (MB) will show more co-contraction to stabilize the knee joint during a step-up task than RA patients with a fixed bearing total knee prosthesis (FB) where this rotational freedom is absent while having the same...journal article 2008