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Genetic variation underlying cognition and its relation with neurological outcomes and brain imagingKnol, Maria J. (author), Heshmatollah, Alis (author), Cremers, Lotte G.M. (author), Ikram, M. Kamran (author), Uitterlinden, André G. (author), van Duijn, Cornelia M. (author), Niessen, W.J. (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author), Adams, Hieab H.H. (author)Cognition in adults shows variation due to developmental and degenerative components. A recent genomewide association study identified genetic variants for general cognitive function in 148 independent loci. Here, we aimed to elucidate possible developmental and neurodegenerative pathways underlying these genetic variants by relating them to...journal article 2019
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- Kool, Maria J. (author), Cremers, Lotte G.M. (author), Heshmatollah, Alis (author), Ikram, M. Kamran (author), Uiterlinden, Andre G. (author), van Duijn, Cornelia M. (author), Niessen, W.J. (author), Vernooij, Meike W. (author), Arfan Ikram, M. (author), Adams, Hieab H.H. (author) journal article 2018
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van der Lee, Sven J. (author), Roshchupkin, Gennady V. (author), Adams, Hieab H. (author), Schmidt, Helena (author), Hofer, Edith (author), Saba, Yasaman (author), Schmidt, Reinhold (author), Hofman, Albert (author), Amin, Najaf (author), van Duijn, Cornelia M. (author), Vernooij, Meike W. (author), Ikram, M. Arfan (author), Niessen, W.J. (author)Background: The combination of genetics and imaging has improved their understanding of the brain through studies of aggregate measures obtained from high-resolution structural imaging. Voxel-wise analyses have the potential to provide more detailed information of genetic influences on the brain. Here they report a large-scale study of the...journal article 2017
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Roshchupkin, Gennady V. (author), Gutman, Boris A. (author), Vernooij, Meike W. (author), Jahanshad, Neda (author), Martin, Nicholas G. (author), Hofman, Albert (author), McMahon, Katie L. (author), van der Lee, S.J. (author), van Duijn, Cornelia M. (author), De Zubicaray, Greig I. (author), Uitterlinden, André G. (author), Wright, Margaret J. (author), Niessen, W.J. (author), Thompson, Paul M. (author), Ikram, M. Arfan (author), Adams, Hieab H. (author)The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum,...journal article 2016