Searched for: author:"Noorman, H.J."
(1 - 19 of 19)
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Almeida Benalcazar, E.F. (author), Noorman, H.J. (author), Maciel Filho, Rubens (author), Posada Duque, J.A. (author)
Background: Ethanol production through fermentation of gas mixtures containing CO, CO<sub>2</sub> and H<sub>2</sub> has just started operating at commercial scale. However, quantitative schemes for understanding and predicting productivities, yields, mass transfer rates, gas flow profiles and detailed energy requirements have been lacking in...
journal article 2020
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Magalhaes de Medeiros, E. (author), Noorman, H.J. (author), Maciel Filho, Rubens (author), Posada Duque, J.A. (author)
In this work, a model was developed to predict the performance of a bubble column reactor for syngas fermentation and the subsequent recovery of anhydrous ethanol. The model was embedded in an optimization framework which employs surrogate models (artificial neural networks) and multi-objective genetic algorithm to optimize different process...
journal article 2020
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Hajian, Christopher Sarkizi Shams (author), Haringa, Cees (author), Noorman, H.J. (author), Takors, Ralf (author)
Scaling up bioprocesses is one of the most crucial steps in the commercialization of bioproducts. While it is known that concentration and shear rate gradients occur at larger scales, it is often too risky, if feasible at all, to conduct validation experiments at such scales. Using computational fluid dynamics equipped with mechanistic...
journal article 2020
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Straathof, Adrie J.J. (author), Wahl, S.A. (author), Benjamin, Kirsten R. (author), Takors, Ralf (author), Wierckx, Nick (author), Noorman, H.J. (author)
Future manufacturing will focus on new, improved products as well as on new and enhanced production methods. Recent biotechnological and scientific advances, such as CRISPR/Cas and various omic technologies, pave the way to exciting novel biotechnological research, development, and commercialization of new sustainable products. Rigorous...
review 2019
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Magalhaes de Medeiros, E. (author), Posada Duque, J.A. (author), Noorman, H.J. (author), Filho, Rubens Maciel (author)
Syngas fermentation is one of the bets for the future sustainable biobased economies due to its potential as an intermediate step in the conversion of waste carbon to ethanol fuel and other chemicals. Integrated with gasification and suitable downstream processing, it may constitute an efficient and competitive route for the valorization of...
journal article 2019
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Wang, G. (author), Zhao, Junfei (author), Haringa, C. (author), Tang, W. (author), Xia, Jianye (author), Chu, Ju (author), Zhuang, Yingping (author), Zhang, Siliang (author), Deshmukh, A.T. (author), van Gulik, W.M. (author), Heijnen, J.J. (author), Noorman, H.J. (author)
In a 54 m<sup>3</sup> large-scale penicillin fermentor, the cells experience substrate gradient cycles at the timescales of global mixing time about 20–40 s. Here, we used an intermittent feeding regime (IFR) and a two-compartment reactor (TCR) to mimic these substrate gradients at laboratory-scale continuous cultures. The IFR was applied to...
journal article 2018
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Haringa, C. (author), Tang, W. (author), Wang, G. (author), Deshmukh, A.T. (author), van Winden, Wouter A. (author), Chu, Ju (author), van Gulik, W.M. (author), Heijnen, J.J. (author), Mudde, R.F. (author), Noorman, H.J. (author)
We assess the effect of substrate heterogeneity on the metabolic response of P. chrysogenum in industrial bioreactors via the coupling of a 9-pool metabolic model with Euler-Lagrange CFD simulations. In this work, we outline how this coupled hydrodynamic-metabolic modeling can be utilized in 5 steps. (1) A model response study with a fixed...
journal article 2018
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Lu, Hongzhong (author), Cao, Weiqiang (author), Liu, X. (author), Sui, Yufei (author), Ouyang, Liming (author), Xia, Jianye (author), Huang, Mingzhi (author), Zhuang, Yingping (author), Zhang, Siliang (author), Noorman, H.J. (author), Chu, Ju (author)
Oxygen limitation is regarded as a useful strategy to improve enzyme production by mycelial fungus like Aspergillus niger. However, the intracellular metabolic response of A. niger to oxygen limitation is still obscure. To address this, the metabolism of A. niger was studied using multi-omics integrated analysis based on the latest GEMs ...
journal article 2018
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Haringa, C. (author), Mudde, R.F. (author), Noorman, H.J. (author)
Euler–Lagrange computational fluid dynamics simulations offer great potential for the integration of transport dynamics and metabolic dynamics in fermentation systems. Since the seminal work of Lapin et al. [1,2], progress has been made, mainly in the analysis of CFD data and translation to laboratory setup designs. Different large-scale...
journal article 2018
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Noorman, H.J. (author), Heijnen, J.J. (author)
Building on the recent revolution in molecular biology, enabling a wealth of bio-product innovations made from renewable feedstocks, the biotechnology field is in a transition phase to bring the products to the market. This requires a shift from natural sciences to engineering sciences with first conception of new, efficient large-scale...
journal article 2017
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Delvigne, Frank (author), Takors, Ralf (author), Mudde, R.F. (author), van Gulik, W.M. (author), Noorman, H.J. (author)
Efficient optimization of microbial processes is a critical issue for achieving a number of sustainable development goals, considering the impact of microbial biotechnology in agrofood, environment, biopharmaceutical and chemical industries. Many of these applications require scale-up after proof of concept. However, the behaviour of...
journal article 2017
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Redl, Stephanie (author), Sukumara, Sumesh (author), Ploeger, Tom (author), Wu, Liang (author), Ølshøj Jensen, Torbjørn (author), Nielsen, Alex Toftgaard (author), Noorman, H.J. (author)
Background: Syngas fermentation is a promising option for the production of biocommodities due to its abundance and compatibility with anaerobic fermentation. Using thermophilic production strains in a syngas fermentation process allows recovery of products with low boiling point from the off-gas via condensation. Results: In this study we...
journal article 2017
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Haringa, C. (author), Deshmukh, Amit T. (author), Mudde, R.F. (author), Noorman, H.J. (author)
With reaction timescales equal to or shorter than the circulation time, the ideal mixing assumption typically does not hold for large scale bioreactors. As a consequence large scale gradients in extra-cellular conditions such as the substrate concentration exist, which may significantly impact the metabolism of micro-organisms and thereby the...
journal article 2017
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Haringa, C. (author), Noorman, H.J. (author), Mudde, R.F. (author)
Large substrate concentration gradients can exist in chemical or biochemical reactions, resulting from a large circulation time compared to the turnover time of substrates. The influence of such gradients on the microbial metabolism can significantly compromise optimal bioreactor performance. Lapin et al. (2004) proposed an Euler–Lagrange CFD...
journal article 2017
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Delvigne, Frank (author), Noorman, H.J. (author)
The bio-economy is in transit from innovation to commercialization. The bioprocess industry is expected to increasingly deliver bio-products to the market, in large amounts, at high quality and at competitive cost levels. This requires flawless start-up of new large-scale bioprocesses and continuous improvement of running processes....
journal article 2017
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Haringa, C. (author), Tang, Wenjun (author), Deshmukh, Amit T. (author), Xia, Jianye (author), Reuss, Matthias (author), Heijnen, J.J. (author), Noorman, H.J. (author), Mudde, R.F. (author)
The trajectories, referred to as lifelines, of individual microorganisms in an industrial scale fermentor under substrate limiting conditions were studied using an Euler-Lagrange computational fluid dynamics approach. The metabolic response to substrate concentration variations along these lifelines provides deep insight in the dynamic...
journal article 2016
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Lu, Hongzhong (author), Liu, Xiaoyun (author), Huang, Mingzhi (author), Xia, Jianye (author), Chu, Ju (author), Zhuang, Yingping (author), Zhang, Siliang (author), Noorman, H.J. (author)
Background: Aspergillus niger is widely used for enzyme production and achievement of high enzyme production depends on the comprehensive understanding of cell's metabolic regulation mechanisms. Results: In this paper, we investigate the metabolic differences and regulation mechanisms between a high glucoamylase-producing strain A. niger...
journal article 2015
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Noorman, H.J. (author), Rakels, J.L.L. (author), Kuenen, J.G. (author), Luyben, K. (author), Heijnen, J.J. (author)
journal article 1992
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Noorman, H.J. (author)
doctoral thesis 1991
Searched for: author:"Noorman, H.J."
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