Total knee arthroplasty improves gait adaptability in osteoarthritis patients; a pilot study

Background: Gait adaptability is of utmost importance for keeping balance during gait in patients with knee osteoarthritis, also after total knee arthroplasty (TKA). The aims of this explorative study are: (1) assess the effect of age, knee osteoarthritis and TKA on gait adaptability; (2) assess changes in gait adaptability pre-to post-TKA...

Inter-laboratory comparison of knee biomechanics and muscle activation patterns during gait in patients with knee osteoarthritis

Background: Gait analysis has been used for decades to quantify knee function in patients with knee osteoarthritis; however, it is unknown whether and to what extent inter-laboratory differences affect the comparison of gait data between studies. Therefore, the aim of this study was to perform an inter-laboratory comparison of knee...

Matching walking speed of controls affects identification of gait deviations in patients with a total knee replacement

Background: The assessment of functional recovery of patients after a total knee replacement includes the quantification of gait deviations. Comparisons to comfortable gait of healthy controls may incorrectly suggest biomechanical gait deviations, since the usually lower walking speed of patients already causes biomechanical differences....

Effect of walking with a modified gait on activation patterns of the knee spanning muscles in people with medial knee osteoarthritis

Objective: To evaluate muscle activation patterns and co-contraction around the knee in response to walking with modified gait patterns in patients with medial compartment knee-osteoarthritis (KOA). Design: 40 medial KOA patients walked on an instrumented treadmill. Surface EMG activity from seven knee-spanning muscles (gastrocnemius,...

Precision of determining bone pose and marker position in the foot and lower leg from computed tomography scans: How low can we go in radiation dose?

Computed tomography (CT) imaging can be used to determine bone pose, sometimes combined with skin-mounted markers. For this specific application, a lower radiation dose than the conventional clinical dose might suffice. This study aims to determine how lowering the radiation dose of a CT-scan of the ankle and foot affects the precision of...

Gait retraining using real-time feedback in patients with medial knee osteoarthritis: Feasibility and effects of a six-week gait training program

Background: The knee adduction moment (KAM) is often elevated in medial knee osteoarthritis (KOA). The aim of this study was to evaluate effects on KAM and patient-reported outcomes of a six-week gait training program. Methods: Twenty-one patients (61 ± 6 years) with KOA participated in a six-week biofeedback training program to encourage...

Relationship between knee joint contact forces and external knee joint moments in patients with medial knee osteoarthritis: effects of gait modifications

Objective: To evaluate 1) the relationship between the knee contact force (KCF) and knee adduction and flexion moments (KAM and KFM) during normal gait in people with medial knee osteoarthritis (KOA), 2) the effects on the KCF of walking with a modified gait pattern and 3) the relationship between changes in the KCF and changes in the knee...

Allerheiligenvloed 2006: Achtergrondverslag van de stormvloed van 1 november 2006

De stormvloed van 1 november 2006, de Allerheiligenvloed genaamd, heeft na analyse van de waterstandsverwachting, de golfmetingen bij Schiermonnikoog Noord (SON), de veekranden en de duinafslag, geleid tot aanbevelingen voor het informatie- en kennisontwikkelingsproces. Het betreft aanbevelingen voor het instrumentarium van de SVSD, voor het...

Torque-limited RecA polymerization on dsDNA

Dual architectural roles of HU: Formation of flexible hinges and rigid filaments

Initiation of translocation by Type I restriction-modification enzymes is associated with a short DNA extrusion

The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility

Human Rad51 filaments on double- and single-stranded DNA: Correlating regular and irregular forms with recombination function

Recombinase proteins assembled into helical filaments on DNA are believed to be the catalytic core of homologous recombination. The assembly, disassembly and dynamic rearrangements of this structure must drive the DNA strand exchange reactions of homologous recombination. The sensitivity of eukaryotic recombinase activity to reaction conditions...