Searched for: author:"Osch, G.J.V.M."
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Bomer, N. (author), Den Hollander, W.T.H.F. (author), Ramos, Y.F.M. (author), Bos, S.D. (author), Van der Breggen, R. (author), Lakenberg, N. (author), Pepers, B.A. (author), Van Eeden, A.E. (author), Darvishan, A. (author), Tobi, E.W. (author), Duijnisveld, B.J. (author), Van den Akker, E.B. (author), Heijmans, B.T. (author), Van Roon-Mom, W.M.C. (author), Verbeek, F.J. (author), Osch, G.J.V.M. (author), Nelissen, R.G.H.H. (author), Slagboom, P.E. (author), Meulenbelt, I. (author)
Objectives: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. Methods: Epigenetically regulated expression of DIO2 was explored by assessing methylation of positional CpG...
journal article 2015
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Siebelt, M. (author), Groen, H.C. (author), Koelewijn, S.J. (author), De Blois, E. (author), Sandker, M. (author), Waarsing, J.H. (author), Müller, C. (author), Van Osch, G.J.V.M. (author), De Jong, M. (author), Weinans, H.H. (author)
Introduction Articular cartilage needs sulfated-glycosaminoglycans (sGAGs) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical exercise is known to improve cartilage sGAG content and might protect against osteoarthritis (OA). This study investigated...
journal article 2014
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Van Buul, G. (author), Kotek, G. (author), Wielopolski, P.A. (author), Farrell, E. (author), Bos, P.K. (author), Weinans, H. (author), Grohnert, A.U. (author), Jahr, H. (author), Verhaar, J.A.N. (author), Krestin, G.P. (author), Van Osch, G.J.V.M. (author), Bernsen, M.R. (author)
Background: Articular cartilage has very limited intrinsic regenerative capacity, making cell-based therapy a tempting approach for cartilage repair. Cell tracking can be a major step towards unraveling and improving the repair process of these therapies. We studied superparamagnetic iron oxides (SPIO) for labeling human bone marrow-derived...
journal article 2011