Searched for: author%3A%22Peirlinck%2C+M.%22
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Gheysen, Lise (author), Maes, Lauranne (author), Caenen, Annette (author), Segers, Patrick (author), Peirlinck, M. (author), Famaey, Nele (author)
Personalized treatment informed by computational models has the potential to markedly improve the outcome for patients with a type B aortic dissection. However, existing computational models of dissected walls significantly simplify the characteristic false lumen, tears and/or material behavior. Moreover, the patient-specific wall thickness...
journal article 2024
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Peirlinck, M. (author), Linka, Kevin (author), Hurtado, Juan A. (author), Kuhl, Ellen (author)
Constitutive modeling is the cornerstone of computational and structural mechanics. In a finite element analysis, the constitutive model is encoded in the material subroutine, a function that maps local strains onto stresses. This function is called within every finite element, at each integration point, within every time step, at each Newton...
journal article 2024
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Kolawole, F. O. (author), Peirlinck, M. (author), Cork, T. E. (author), Levenston, M. (author), Kuhl, Ellen (author), Ennis, D. B. (author)
Impaired cardiac filling in response to increased passive myocardial stiffness contributes to the pathophysiology of heart failure. By leveraging cardiac MRI data and ventricular pressure measurements, we can estimate in vivo passive myocardial stiffness using personalized inverse finite element models. While it is well-known that this...
journal article 2023
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Pentenga, Puck (author), Stroh, Ashley (author), van Genuchten, Wouter (author), Helbing, Wim A. (author), Peirlinck, M. (author)
Computational heart modeling is a promising approach for improving the prognosis of patients born with congenital heart defects. To create accurate physics-based digital cardiac twins of this population, it is crucial to accurately represent the highly diverse and unique subject-specific heart geometry. In young pediatric patients, this is a...
conference paper 2023
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Tikenoğulları, O. Z. (author), Peirlinck, M. (author), Chubb, H. (author), Dubin, A. M. (author), Kuhl, E. (author), Marsden, A. L. (author)
Single ventricle patients, including those with hypoplastic left heart syndrome (HLHS), typically undergo three palliative heart surgeries culminating in the Fontan procedure. HLHS is associated with high rates of morbidity and mortality, and many patients develop arrhythmias, electrical dyssynchrony, and eventually ventricular failure....
journal article 2023
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Gülcher, Oskar J. (author), Vis, Annemijn (author), Peirlinck, M. (author), Kluin, Jolanda (author)
Background: Maintaining balanced left and right cardiac outputs in a total artificial heart (TAH) is challenging due to the need for continuous adaptation to changing hemodynamic conditions. Proper balance in ventricular outputs of the left and right ventricles requires a preload-sensitive response and mechanisms to address the higher...
review 2023
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St. Pierre, Sarah R. (author), Peirlinck, M. (author), Kuhl, Ellen (author)
Cardiovascular disease in women remains under-diagnosed and under-treated. Recent studies suggest that this is caused, at least in part, by the lack of sex-specific diagnostic criteria. While it is widely recognized that the female heart is smaller than the male heart, it has long been ignored that it also has a different microstructural...
review 2022
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Peirlinck, M. (author), Yao, J. (author), Sahli Costabal, F. (author), Kuhl, E. (author)
Many drugs interact with ion channels in the cells of our heart and trigger heart rhythm disorders with potentially fatal consequences. Computational modeling can provide mechanistic insight into the onset and propagation of drug-induced arrhythmias, but the effect of drugs on the mechanical performance of the heart remains poorly understood....
journal article 2022
Searched for: author%3A%22Peirlinck%2C+M.%22
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