Searched for: author%3A%22Righolt%2C+C.H.%22
(1 - 9 of 9)
document
Sathitruangsak, C. (author), Righolt, C.H. (author), Klewes, L. (author), Tammur, P. (author), Ilus, T. (author), Tamm, A. (author), Punab, M. (author), Olujohungbe, A. (author), Mai, S. (author)
The mammalian nucleus has a distinct substructure that cannot be visualized directly by conventional microscopy. In this study, the organization of the DNA within the nucleus of multiple myeloma (MM) cells, their precursor cells (monoclonal gammopathy of undetermined significance; MGUS) and control lymphocytes of the representative patients is...
journal article 2015
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Righolt, C.H. (author), Van VLiet, L.J. (author), Stallinga, S. (author)
Filtering module for transforming one or more input images into at least one synthesized output image is described wherein one or more input images are generated by an optical- digital imaging system associated with a non-filtered optical transfer function and wherein said filter module comprises: one or more filtering functions that are...
patent 2014
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Righolt, C.H. (author), Guffei, A. (author), Knecht, H. (author), Young, I.T. (author), Stallinga, S. (author), Van Vliet, L.J. (author), Mai, S. (author)
Advances in light microscopy have enabled the visualization of DNA in the interphase nucleus with more detail than is visible with conventional light microscopy. The nuclear architecture is assumed to be different in cancer cells compared to normal cells. In this paper we have studied, for the first time, the organization of nuclear DNA and that...
journal article 2014
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Schmälter, A.K. (author), Kuzyk, A. (author), Righolt, C.H. (author), Neusser, M. (author), Steinlein, O.K. (author), Müller, S. (author), Mai, S. (author)
Background Characterizing the nuclear orientation of chromosomes in the three-dimensional (3D) nucleus by multicolor banding (mBANDing) is a new approach towards understanding nuclear organization of chromosome territories. An mBANDing paint is composed of multiple overlapping subchromosomal probes that represent different regions of a single...
journal article 2014
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Righolt, C.H. (author)
Advances in light microscopy lead to breakthroughs in biology. To further unravel the mysteries of life and the mechanisms behind diseases, better microscope techniques are needed to validate biological hypotheses. This thesis presents how integration of optics and computing leads to better images for quantitative microscopy and how quantitative...
doctoral thesis 2014
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Righolt, C.H. (author), Mai, S. (author), Van Vliet, L.J. (author), Stallinga, S. (author)
The quality of the reconstructed image in structured illumination microscopy (SIM) depends on various aspects of the image filtering process. To optimize the trade-off between resolution and ringing artifacts, which lead to negative intensities, we extend Lukosz-bound filtering to 3D SIM and derive the parametrization of the 3D SIM cut-off. We...
journal article 2014
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Righolt, C.H. (author), Slotman, J.A. (author), Young, I.T. (author), Mai, S. (author), Van Vliet, L.J. (author), Stallinga, S. (author)
Various aspects of image filtering affect the final image quality in Structured Illumination Microscopy, in particular the regularization parameter and type of regularization function, the relative height of the side bands, and the shape of the apodization function. We propose an apodization filter without adjustable parameters based on the...
journal article 2013
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Righolt, C.H. (author), Zatreanu, D.A. (author), Raz, V. (author)
The nuclear lamina is the structural scaffold of the nuclear envelope that plays multiple regulatory roles in chromatin organization and gene expression as well as a structural role in nuclear stability. The lamina proteins, also referred to as lamins, determine nuclear lamina organization and define the nuclear shape and the structural...
journal article 2013
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Righolt, C.H. (author), Raz, V. (author), Vermolen, B.J. (author), Dirks, R.W. (author), Tanke, H.J. (author), Young, I.T. (author)
The nuclear lamina is an intermediate filament network that provides a structural framework for the cell nucleus. Changes in lamina structure are found during changes in cell fate such as cell division or cell death and are associated with human diseases. An unbiased method that quantifies changes in lamina shape can provide information on cells...
journal article 2011
Searched for: author%3A%22Righolt%2C+C.H.%22
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