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Rashidi, A. (author), Varkevisser, F. (author), Giagka, Vasiliki (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)Electrical stimulation is proven to be an effective way of neuromodulation in bioelectronic medicine (e.g. cochlear implants, deep brain stimulators, etc.), delivering localized treatment by the means of electrical pulses. To increase the stimulation efficiency and neural-type selectivity, there is an increasing interest to employ non...abstract 2023
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Velea, A. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)In an attempt to reduce the side effects caused by the chemically-based drugs used to treat neurological disorders, the field of bioelectronics has been focusing on the development of smart and reliable solutions that could, ideally, interact with the tissue at a resolution of individual cells.1 Conventionally, electrically-based systems have...abstract 2022
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Kolovou Kouri, K. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)During the last few decades, electrical neural stimulators have successfully been employed as a means of treatment for a wide range of neurological disorders. By targeting the peripheral and central nervous systems, electrical neurostimulators activate/inhibit neural activity by manipulating the stimulus- induced electric field arising at the...abstract 2022
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Varkevisser, F. (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)Power efficiency in electrical stimulator circuits is crucial for developing large-scale multichannel applications like bidirectional brain-computer interfaces and neuroprosthetic devices. Many state-of-the-art papers have suggested that some non-rectangular pulse shapes are more energy-efficient for exciting neural excitation than the...journal article 2022
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Siddiqi, M.A. (author), Hahn, Georg (author), Hamdioui, S. (author), Serdijn, W.A. (author), Strydis, C. (author)A Medical Body Area Network (MBAN) is an ensemble of collaborating, potentially heterogeneous, medical devices located inside, on the surface of or around the human body with the objective of tackling one or multiple medical conditions of the MBAN host. These devices-which are a special category of Wireless Body Area Networks (WBANs)–collect,...journal article 2022
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Panskus, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Over the past decades, neuromodulation has been proven to be an effective treatment for several neurological disorders. Moreover, it continues to be a rapidly evolving field with a wide-ranging potential for biomedical applications. However, efficient and patient-specific targeted neuromodulation remains one of the biggest challenges for...abstract 2022
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Bakhshaee Babaroud, N. (author), Palmar, M. (author), Velea, A. (author), Coletti, C. (author), Weingärtner, S.D. (author), Vos, F.M. (author), Serdijn, W.A. (author), Vollebregt, S. (author), Giagka, Vasiliki (author)Multimodal platforms combining electrical neural recording and stimulation, optogenetics, optical imaging, and magnetic resonance (MRI) imaging are emerging as a promising platform to enhance the depth of characterization in neuroscientific research. Electrically conductive, optically transparent, and MRI-compatible electrodes can optimally...journal article 2022
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Coolen, R.J.J. (author), Emmer, K.M. (author), Spantidea, P.I. (author), Asselt, E. van (author), Scheepe, J.R. (author), Serdijn, W.A. (author), Blok, B.F.M. (author)The first two objectives were to establish which stimulation parameters of kilohertz frequency alternating current (KHFAC) neuromodulation influence the effectiveness of pudendal nerve block and its safety. The third aim was to determine whether KHFAC neuromodulation of the pudendal nerve can relax the pelvic musculature, including the anal...journal article 2022
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Safarpour, Amin (author), Dehnavi, Farzaneh (author), Saberi, Mehdi (author), Lotfi, R. (author), Serdijn, W.A. (author)In multi-electrode arrays (MEAs), for electrical recording and electrical stimulation, high voltage (HV) switches are employed to build an analog multiplexer to conduct either a HV stimulation signal from the pulse generator circuit to an electrode or a low-voltage noise-sensitive signal from the electrode to a recording stage. In this brief,...journal article 2022
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Kolovou Kouri, K. (author), Rashidi, A. (author), Varkevisser, F. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)In neuromodulation applications, conventional current mode stimulation is often preferred over its voltage mode equivalent due to its good control of the injected charge. However, it comes at the cost of less energy-efficient output stages. To increase energy efficiency, recent studies have explored non-rectangular stimuli. The current work...conference paper 2022
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Varkevisser, F. (author), Rashidi, A. (author), Lopes Marta da Costa, T.M. (author), Giagka, Vasiliki (author), Serdijn, W.A. (author)This work proposes a guideline for designing more energy-efficient electrical stimulators by analyzing the frequency spectrum of the stimuli. It is shown that the natural low-pass characteristic of the neuron’s membrane limits the energy transfer efficiency from the stimulator to the cell. Thus, to improve the transfer efficiency, it is proposed...conference paper 2022
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Brash, Rohan (author), Serdijn, W.A. (author), Muratore, D.G. (author)This paper introduces a fast artifact recovery algorithm (FARA) that uses electrochemical impedance spectroscopy to model the electrode-tissue interface and design an optimum stimulation waveform to minimize the residual artifact duration in single-cell resolution neural interfaces. Results in saline solution with a custom PCB and a 30 $\mu ...conference paper 2022
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Dilevicius, Ignas (author), Serdijn, W.A. (author), Lopes Marta da Costa, T.M. (author)Deep brain stimulation is currently the only technique used in the clinical setting to modulate the neural activity of deep brain nuclei. Recently, low-intensity transcranial focused ultrasound (LIFU) has been shown to reversibly modulate brain activity through a transcranial pathway. Transcranial LIFU requires a low-frequency ultrasound of...conference paper 2022
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Kolovou Kouri, K. (author), Soloukey, Sadaf (author), Harhangi, Biswadjiet (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)Spinal Cord Injury (SCI) is characterized by a disruption of the spinal pathways connecting the brain to the rest of the body. This can result in an impairment or complete loss of sensory and/or motor functions, depending on the level and severity of the injury. The most common approach of attempting motor recovery using neuromodulation has been...abstract 2021
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Coolen, R.L. (author), Emmer, K.M. (author), Spantidea, P.I. (author), Asselt, E. van (author), Scheepe, J.R. (author), Serdijn, W.A. (author), Blok, B.F.M. (author)Hoogfrequente stimulatie met bifasische blokpulsen in de kHz-range induceert een tijdelijke zenuwgeleidingsblokkade. Toegepast op de nervus pudendus, kan het de bekkenmusculatuur ontspannen. Dit kan helpen bij het legen van de blaas en de darmen, hetgeen een nieuwe therapie biedt voor urineretentie en disfunctionele defecatie. Deze studie is...journal article 2021
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Kandilakis, E. (author), Serdijn, W.A. (author), Akgün, O.C. (author)In this paper, we present the design of a low-voltage, low-power, and small-area time-mode ADC (TM-ADC) for bio-signal sensing applications. The proposed time-mode ADC (TM-ADC) consists of a programmable oversampling ratio (OSR), voltage-controlled ring oscillator (VCRO) based analog-to-time converter (ATC), followed by an asynchronous unfolded...conference paper 2021
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Martins Da Ponte, R. (author), Gaio, N. (author), van Zeijl, H.W. (author), Vollebregt, S. (author), Dijkstra, Paul (author), Dekker, R. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)One of the many applications of organ-on-a-chip (OOC) technology is the study of biological processes in human induced pluripotent stem cells (iPSCs) during pharmacological drug screening. It is of paramount importance to construct OOCs equipped with highly compact in situ sensors that can accurately monitor, in real time, the extracellular...journal article 2021
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de Goederen, R. (author), Pu, S. (author), Silos Viu, M. (author), Doan, D. (author), Overeem, S. (author), Serdijn, W.A. (author), Joosten, K. F.M. (author), Long, X. (author), Dudink, J. (author)Study objectives: Unobtrusive monitoring of sleep and sleep disorders in children presents challenges. We investigated the possibility of using Ultra-Wide band (UWB) radar to measure sleep in children. Methods: Thirty-two children scheduled to undergo a clinical polysomnography participated; their ages ranged from 2 months to 14 years. During...journal article 2021
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Kolovou Kouri, K. (author), Soloukey, Sadaf (author), Huygen, F.J.P.M. (author), Harhangi, Biswadjiet S. (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)This paper presents the development of a Dorsal Root Ganglion (DRG) stimulator system intended for use in early clinical trials for motor recovery after Spinal Cord Injury (SCI). It allows for independent control of multisite/multilevel bilateral (on both sides of the spinal cord) stimulation, it can supply a high output current of 25.4mA,...conference paper 2021
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Celentano, A. (author), Pareschi, Fabio (author), Valente, V. (author), Rovatti, Riccardo (author), Serdijn, W.A. (author), Setti, Gianluca (author)We consider the design of Wireless Power Transfer (WPT) systems based on inductive links and focus on recent works where the whole WPT system (i.e. both energy transmitter and energy receiver) is designed as an isolated resonant class-E DC-DC converter characterized by a loosely-coupled transformer. The aim of this work is to compare the classic...conference paper 2021