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Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Two porphyrinic metal-organic frameworks (PCN-222 and PCN-224) were prepared and their potential as molybdenum adsorbents for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was explored. The molybdenum adsorption properties of the two adsorbents, including adsorption kinetics and equilibrium isotherms, were evaluated at different molybdenum...journal article 2023
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Ma, C. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The cerium-based metal–organic framework UiO-66 (Ce) was examined as a potential adsorbent for the <sup>99</sup>Mo/<sup>99m</sup>Tc generator. The results showed that the adsorbent had an outstanding adsorption performance, reaching up to 475 mg/g adsorption capacity at pH 3. An adsorption mechanism was proposed, where the adsorption was...journal article 2022
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Ma, C. (author), Liu, H. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Four different MOFs were exposed to γrays by a cobalt-60 source reaching a maximum dose of 5 MGy. The results showed that the MIL-100 (Cr) and MIL-100 (Fe) did not exhibit obvious structural damage, suggesting their excellent radiation stability. MIL-101 (Cr) showed good radiation stability up to 4 MGy, but its structure started degrading...journal article 2022
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Ma, C. (author), Vasileiadis, A. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)The potential of the metal–organic framework UiO-66 and its functionalized derivatives for their utilization in the <sup>99</sup>Mo/<sup>99m</sup>Tc generator was assessed. Molybdenum adsorption experiments, structure characterization, molecular simulations and column experiments with molybdenum-99 were carried out. The results showed that...journal article 2021
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Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)A solid phase extraction based <sup>177m</sup>Lu-<sup>177</sup>Lu separation method has been investigated for its feasibility to be used in the radionuclide generator. The use of 2,2′,2”-(10-(2,6-dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid, (DOTAGA-anhydride) allowed grafting of DOTA (1,4,7,10...journal article 2020
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Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)In order to determine the potential of <sup>177m</sup>Lu/<sup>177</sup>Lu radionuclide generator in <sup>177</sup>Lu production it is important to establish the technical needs that can lead to a clinically acceptable <sup>177</sup>Lu product quality. In this work, a model that includes all the processes and the parameters affecting the...journal article 2020
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Bhardwaj, R. (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)Background In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelled peptide (DOTATATE) and liquid-liquid extraction. Methods The 177mLu cations were complexed with DOTA &...journal article 2019
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Osadchii, D. (author), Olivos Suarez, A.I. (author), Szécsényi, A. (author), Li, G. (author), Nasalevich, M. (author), Dugulan, A.I. (author), Serra Crespo, P. (author), Hensen, Emiel J.M. (author), Veber, Sergey L. (author), Fedin, Matvey V. (author), Sankar, Gopinathan (author), Pidko, E.A. (author), Gascon, Jorge (author)Hybrid materials bearing organic and inorganic motifs have been extensively discussed as playgrounds for the implementation of atomically resolved inorganic sites within a confined environment, with an exciting similarity to enzymes. Here, we present the successful design of a site-isolated mixed-metal metal organic framework (MOF) that...journal article 2018
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Cambraia Lopes Ferreira da Silva, P. (author), Serra Crespo, P. (author), Huizenga, J. (author), Schaart, D.R. (author)Much attention is currently being paid to imaging prompt gamma (PG) rays for in vivo proton range monitoring in proton therapy. PG imaging using a collimator is affected by neutron-related background. We study the effectiveness of background reduction experimentally, using a scanning parallel-slit PG collimator as a simplified model of a...journal article 2018
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Bhardwaj, R. (author), van der Meer, A.J.G.M. (author), Das, S.K. (author), de Bruin, M (author), Gascon, Jorge (author), Wolterbeek, H.T. (author), Denkova, A.G. (author), Serra Crespo, P. (author)177Lu has sprung as a promising radionuclide for targeted therapy. The low soft tissue penetration of its β− emission results in very efficient energy deposition in small-size tumours. Because of this, 177Lu is used in the treatment of neuroendocrine tumours and is also clinically approved for prostate cancer therapy. In this work, we report a...journal article 2017
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Denkova, A.G. (author), de Kruijff, R.M. (author), Serra Crespo, P. (author)Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treatments. However, most preclinical studies show that complete elimination of tumors is rarely...journal article 2017
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Dikhtiarenko, A. (author), Serra Crespo, P. (author), Castellanos Ortega, S. (author), Pustovarenko, Alexey (author), Mendoza-Merono, Rafael (author), García-Granda, Santiago (author), Gascon, Jorge (author)Three supramolecular isomers of lutetium metal-organic framework, {Lu<sub>2</sub>(H<sub>2</sub>O)<sub>4</sub>(ATA)<sub>3</sub>·4H<sub>2</sub>O}<sub>n</sub> (Lu-ATA@RT), {Lu<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>(C<sub>3</sub>H<sub>7</sub>NO)<sub>2</sub>(ATA)<sub>3</sub>}<sub>n</sub> (Lu-ATA@100), and {Lu<sub>2</sub>(C<sub>3</sub>H<sub>7</sub...journal article 2016
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Goesten, M.G. (author), de Lange, M.F. (author), Olivos Suarez, A.I. (author), Bavykina, A.V. (author), Serra Crespo, P. (author), Krywka, C. (author), Bickelhaupt, F. M. (author), Kapteijn, F. (author), Gascon, Jorge (author)Chemical clocks are often used as exciting classroom experiments, where an induction time is followed by rapidly changing colours that expose oscillating concentration patterns. This type of reaction belongs to a class of nonlinear chemical kinetics also linked to chaos, wave propagation and Turing patterns. Despite its vastness in occurrence...journal article 2016
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- Szilagyi, Petra (author), Serra Crespo, P. (author), Gascon, Jorge (author), Geerlings, J.J.C. (author), Dam, B. (author) journal article 2016
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- Serra Crespo, P. (author) doctoral thesis 2014
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García-Pérez, E. (author), Serra-Crespo, P. (author), Hamad, S. (author), Kapteijn, F. (author), Gascon, J. (author)Simulation of gas adsorption in flexible porous materials is still limited by the slow progress in the development of flexible force fields. Moreover, the high computational cost of such flexible force fields may be a drawback even when they are fully developed. In this work, molecular simulations of gas adsorption and diffusion of carbon...journal article 2014
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Serra-Crespo, P. (author), Dikhtiarenko, A. (author), Stavitski, E. (author), Juan-Alcañiz, J. (author), Kapteijn, F. (author), Coudert, F.X. (author), Gascon, J. (author)We report a series of powder X-ray diffraction experiments performed on the soft porous crystals MIL-53(Al) and NH2-MIL-53(Al) in a diamond anvil cell under different pressurization media. Systematic refinements of the obtained powder patterns demonstrate that these materials expand along a specific direction while undergoing total volume...journal article 2014
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Juan-Alcaniz, J. (author), Gielisse, R. (author), Lago, A.B. (author), Ramos-Fernandez, E.V. (author), Serra-Crespo, P. (author), Devic, T. (author), Guillou, N. (author), Serre, C. (author), Kapteijn, F. (author), Gascon, J. (author)In this work, the inclusion of free sulfonic acid groups in highly stable MOFs is explored. The synthesized catalysts have been applied in a model esterification reaction. Two metal organic frameworks bearing sulfonic acid moieties are investigated: HSO3-MIL-101(Cr) synthesized following different approaches and a new structure based on HSO3-bdc...journal article 2013
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Rodenas, T. (author), Van Dalen, M. (author), Garcia-Perez, E. (author), Serra-Crespo, P. (author), Zornoza, B. (author), Kapteijn, F. (author), Gascon, J. (author)Mixed matrix membranes (MMMs) composed of metal organic framework (MOF) fi llers embedded in a polymeric matrix represent a promising alternative for CO 2 removal from natural gas and biogas. Here, MMMs based on NH 2 -MIL-53(Al) MOF and polyimide are successfully synthesized with MOF loadings up to 25 wt% and different thicknesses. At 308 K and ...journal article 2013