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Chandrashekar, A. (author), Givois, A.P.P. (author), Belardinelli, P. (author), Penning, Casper L. (author), Aragon, A.M. (author), Staufer, U. (author), Alijani, F. (author)Quantifying the nanomechanical properties of soft-matter using multi-frequency atomic force microscopy (AFM) is crucial for studying the performance of polymers, ultra-thin coatings, and biological systems. Such characterization processes often make use of cantilever's spectral components to discern nanomechanical properties within a multi...journal article 2022
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Chandrashekar, A. (author), Belardinelli, P. (author), Bessa, M.A. (author), Staufer, U. (author), Alijani, F. (author)Dynamic atomic force microscopy (AFM) is a key platform that enables topological and nanomechanical characterization of novel materials. This is achieved by linking the nanoscale forces that exist between the AFM tip and the sample to specific mathematical functions through modeling. However, the main challenge in dynamic AFM is to quantify...journal article 2022
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Andrew, Philippa Kate (author), Raudsepp, Allan (author), Nock, Volker (author), Fan, D. (author), Williams, Martin A.K. (author), Staufer, U. (author), Avci, Ebubekir (author)Optical micromachines have the potential to improve the capabilities of optical tweezers by amplifying forces and allowing for indirect handling and probing of specimens. However, systematic design and testing of micromachine performance is still an emerging field. In this work we have designed and tested an unsupported microlever, suitable for...conference paper 2022
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ANDREW, PHILIPPA KATE (author), RAUDSEPP, ALLAN (author), Fan, D. (author), Staufer, U. (author), WILLIAMS, MARTIN A.K. (author), AVCI, EBUBEKIR (author)Optical microrobotics is an emerging field that has the potential to improve upon current optical tweezer studies through avenues such as limiting the exposure of biological molecules of interest to laser radiation and overcoming the current limitations of low forces and unwanted interactions between nearby optical traps. However, optical...journal article 2021
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Pleeging, R.M.B. (author), Ibis, F. (author), Fan, D. (author), Sasso, L. (author), Eral, H.B. (author), Staufer, U. (author)Detected kidney stone cases are increasing globally, yet knowledge on the conditions for stone formation is lacking. Experimental approaches mimicking the micro-environmental conditions present in vivo can help sci-entists untangle intertwined physiochemical and biological phenomena leading to kidney stone formation. As crystal nucleation often...journal article 2021
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Mariello, M. (author), Blad, Thijs (author), Mastronardi, V. M. (author), Madaro, F. (author), Guido, F. (author), Staufer, U. (author), Tolou, N. (author), De Vittorio, M. (author)There is a high demand for novel flexible micro-devices for energy harvesting from low-frequency and random mechanical sources. The research of new functional designs is required to strategically enhance the performances and to increase the control on mechanical flexibility. In this work we report the fabrication and characterization of bi...journal article 2021
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Chandrashekar, A. (author), Belardinelli, P. (author), Lenci, Stefano (author), Staufer, U. (author), Alijani, F. (author)Increasing the signal-to-noise ratio in dynamic atomic force microscopy plays a key role in nanomechanical mapping of materials with atomic resolution. In this work, we develop an experimental procedure for increasing the sensitivity of higher harmonics of an atomic-force-microscope cantilever without modifying the cantilever geometry but...journal article 2021
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Nouri Goushki, M. (author), Mirzaali Mazandarani, M. (author), Angeloni, L. (author), Fan, D. (author), Minneboo, M.B. (author), Ghatkesar, M.K. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Fabricating large areas of geometrically complex and precisely controlled topographies is required for the studies of cell behavior on patterned surfaces. Direct laser writing (DLW) is an advanced 3D-fabrication technique, which facilitates the manufacturing of structures within various scales (from a few hundred nanometers to millimeters)....journal article 2020
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Belardinelli, P. (author), D Souza, Savio (author), Verlinden, E.J. (author), Wei, J. (author), Staufer, U. (author), Alijani, F. (author), Ghatkesar, M.K. (author)Suspended microfluidic resonators enable detection of fluid density and viscosity with high sensitivity. Here, a two-legged suspended microchannel resonator that probes pico-litres of liquid is presented. The higher resonant modes (flexural and torsional) were explored for increased sensitivity and resolution. Unlike other reported microchannel...journal article 2020
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Verlinden, E.J. (author), Madadelahi, M. (author), Sarajlic, E. (author), Shamloo, A. (author), Engel, A.H. (author), Staufer, U. (author), Ghatkesar, M.K. (author)We introduce a two-channel microfluidic atomic force microscopy (AFM) cantilever that combines the nanomechanical sensing functionality of an AFM cantilever with the ability to manipulate fluids of picolitres or smaller volumes through nanoscale apertures near the cantilever tip. Each channel is connected to a separate fluid reservoir, which...journal article 2020
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van der Velden, Gijs (author), Fan, D. (author), Staufer, U. (author)Organ-on-chip (OoC) technology is increasingly used for biomedical research and to speed up the process of bringing a drug from lab to the market. The main fluidic components of an OoC device are microfluidic channels and porous membranes arranged in three dimensions. Current chips are often assembled from several parts. In the development...journal article 2020
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Andrew, Philippa Kate (author), Fan, D. (author), Raudsepp, Allan (author), Lofroth, Matthew (author), Staufer, U. (author), Williams, Martin A.K. (author), Avci, Ebubekir (author)Advances in nanofabrication over the past twenty years have enabled the creation and use of ever-more interesting and useful micromachines. Optical micromachines are a particularly attractive subset of these for researchers in biological and soft-matter sciences, due to their potential to aid in optical tweezer studies of laser-sensitive...conference paper 2020
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Nouri Goushki, M. (author), Sharma, Abhishek (author), Sasso, L. (author), Zhang, Shuang (author), van der Eerden, B.C.J. (author), Staufer, U. (author), Fratila-Apachitei, E.L. (author), Zadpoor, A.A. (author)Manufacturing high throughput in vitro models resembling the tissue microenvironment is highly demanded for studying bone regeneration. Tissues such as bone have complex multiscale architectures inside which cells reside. To this end, engineering a microfluidic platform incorporated with three-dimensional (3D) microscaffolds and submicron...journal article 2019
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Fan, D. (author), Staufer, U. (author), Accardo, A. (author)The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at...journal article 2019
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Puce, Salvatore (author), Sciurti, Elisa (author), Rizzi, Francesco (author), Spagnolo, Barbara (author), Qualtieri, Antonio (author), De Vittorio, Massimo (author), Staufer, U. (author)This work aims at developing a new and unconventional Sacrificial Stencil Mask (SSM) technology by exploiting Two-Photon Polymerization (2PP) in an IP-L/SU-8 double layer resist system. The process consists of the sequential deposition of two different resists, such as SU-8 and IPL, onto the same glass substrate, followed by 2PP lithography...journal article 2019
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Chandrashekar, A. (author), Belardinelli, P. (author), Staufer, U. (author), Alijani, F. (author)In this work, we perform a comprehensive analysis of the robustness of attractors in tapping mode atomic force microscopy. The numerical model is based on cantilever dynamics driven in the Lennard–Jones potential. Pseudo-arc-length continuation and basins of attraction are utilized to obtain the frequency response and dynamical integrity of...journal article 2019
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Schwender, J. (author), Tsioutsios, I. (author), Tavernarakis, A. (author), Dong, Quan (author), Jin, Yong (author), Staufer, U. (author), Bachtold, A. (author)We report on an electrical detection method of ultrasensitive carbon nanotube mechanical resonators. The noise floor of the detection method is reduced using a RLC resonator and an amplifier based on a high electron mobility transistor cooled at 4.2 K. This allows us to resolve the resonance frequency of nanotube resonators with an...journal article 2018
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Belardinelli, P. (author), Ghatkesar, M.K. (author), Staufer, U. (author), Alijani, F. (author)Linear and non-linear vibrations of a U-shaped hollow microcantilever beam filled with fluid and interacting with a small particle are investigated. The microfluidic device is assumed to be subjected to internal flowing fluid carrying a buoyant mass. The equations of motion are derived via extended Hamilton's principle and by using Euler...journal article 2017
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- Gramazio, F. (author), Lorenzoni, M. (author), Perez-Murano, F. (author), Rull Trinidad, E. (author), Staufer, U. (author), Fraxedas, J. (author) journal article 2017
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Rull Trinidad, E. (author), Gribnau, T.W. (author), Belardinelli, P. (author), Staufer, U. (author), Alijani, F. (author)The accuracy of measurements in Amplitude Modulation Atomic Force Microscopy (AFM) is directly related to the geometry of the tip. The AFM tip is characterized by its radius of curvature, which could suffer from alterations due to repetitive mechanical contact with the surface. An estimation of the tip change would allow the user to assess...journal article 2017
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