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Van Berlo, R.J.P. (author)
Bioinformatics concerns itself with developing data-driven tools for extracting biological information from high-throughput datasets (e.g. gene expression data, protein interaction data). Until recently, most of these tools focus on analyzing a single source of data. However, all high-throughput measurements are noisy and incomplete. Therefore,...
doctoral thesis 2010
De Groot, M.J.L. (author), Van Berlo, R.J.P. (author), Van Winden, W.A. (author), Verheijen, P.J.T. (author), Reinders, M.J.T. (author), De Ridder, D. (author)
Motivation: Many enzymes are not absolutely specific, or even promiscuous: they can catalyze transformations of more compounds than the traditional ones as listed in e.g. KEGG. This information is currently only available in databases, such as the BRENDA enzyme activity database. In this paper, we propose to model enzyme aspecificity by...
journal article 2009