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Zhang, F. (author), Wu, K. (author), La Zara, D. (author), Sun, F. (author), Quayle, Michael J. (author), Petersson, Gunilla (author), Folestad, Staffan (author), Chew, Jia Wei (author), van Ommen, J.R. (author)For dry powder inhaled formulations, good flow behaviour is vital in re-dispersing the powder. However, inhaled drug powders with a particle size below 10 µm are classified as highly cohesive materials with poor flow characteristics. Here we demonstrate how to alter the flow properties of micronized budesonide powders by depositing different...journal article 2023
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Sewalt, E.J.G. (author), Kalkman, J. (author), van Ommen, J.R. (author), Meesters, G.M.H. (author), van Steijn, V. (author)Properties of powders produced from drying solute-containing droplets arise from the dynamic redistribution of solute during drying. While insights on the dynamic redistribution are instrumental for the rational design of powders and for the optimized operation of equipment such as spray dryers, experimental techniques that allow measuring...journal article 2022
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Nederstigt, Tom A.P. (author), Peijnenburg, Willie J.G.M. (author), Schrama, Maarten (author), van Ommen, J.R. (author), Vijver, Martina G. (author)Recently, the delivery of pesticides through novel controlled-release (nano-)formulations has been proposed intending to reduce (incidental) pesticide translocation to non-target sites. Concerns have however been raised with regards to the potentially enhanced toxicity of controlled-release (nano-)formulations to non-target organisms and...journal article 2022
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Saedy, S. (author), Hiemstra, Nico (author), Benz, D. (author), Van Bui, Hao (author), Nolan, Michael (author), van Ommen, J.R. (author)The promotional effects on photocatalytic hydrogen production of Cu<sub>x</sub>O clusters deposited using atomic layer deposition (ALD) on P25 TiO<sub>2</sub> are presented. The structural and surface chemistry study of Cu<sub>x</sub>O/TiO<sub>2</sub> samples, along with first principles density functional theory simulations, reveal the...journal article 2022
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Kamphorst, R. (author), Wu, K. (author), Salameh, S. (author), Meesters, G.M.H. (author), van Ommen, J.R. (author)The fluidization of cohesive powders has been extensively researched over the years. When looking at literature on the fluidization of cohesive particles, one will often find papers concerned with only micro- or only nano-sized powders. It is, however, unclear whether they should be treated differently at all. In this paper, we look at...journal article 2022
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Santoso, A. (author), Damen, Afke (author), van Ommen, J.R. (author), van Steijn, V. (author)We explore three variants of atomic layer deposition (ALD) to deposit titanium oxide on the soft polymer polydimethylsiloxane (PDMS). We show that the organic solvent resistance of PDMS is increased by two orders of magnitude compared to uncoated PDMS for ALD performed at atmospheric pressure, which results in a unique surface-subsurface...journal article 2022
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Bagemihl, I. (author), Bhatraju, C. (author), van Ommen, J.R. (author), van Steijn, V. (author)Electrochemical reduction of CO<sub>2</sub>using renewable energy is a promising avenue for sustainable production of bulk chemicals. However, CO<sub>2</sub>electrolysis in aqueous systems is severely limited by mass transfer, leading to low reactor performance insufficient for industrial application. This paper shows that structured reactors...journal article 2022
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Feng, Zhen (author), Liu, Daoyin (author), Zhang, Wangle (author), Feng, Hao (author), van Ommen, J.R. (author)Fluidization of nanoparticle agglomerates is a promising technique to process nanoparticles. However, possible elutriation of small agglomerates may cause significant loss of bed material. To obtain the elutriation behavior under stable operation, in this study the elutriation fraction of silica nanoparticle agglomerates is measured in a...journal article 2022
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Benz, D. (author), Van Bui, Hao (author), Hintzen, H.T.J.M. (author), Kreutzer, M.T. (author), van Ommen, J.R. (author)The photocatalytic mechanism of TiO<sub>2</sub> (P25) nanoparticles coated with SiO<sub>2</sub> (SiO<sub>2</sub>:TiO<sub>2</sub>) by atomic layer deposition was investigated. The deposition of SiO<sub>2</sub> on TiO<sub>2</sub> not only gives a photocatalytic improvement for the degradation of both Rhodamine B (3.6–fold) and Acid Blue 9 (3...journal article 2022
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Li, M. (author), Fu, S. (author), Saedy, S. (author), Rajendrakumar, Aparna (author), Tichelaar, F.D. (author), Kortlever, R. (author), van Ommen, J.R. (author)Preparing supported nanoparticles with a well-defined structure, uniform particle size, and composition using conventional catalyst synthesis methods, such as impregnation, precipitation, and deposition-precipitation is challenging. Furthermore, these liquid phase methods require significant solvent consumption, which has sustainable issues...journal article 2022
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Tsalidis, G.A. (author), Soeteman-Hernández, Lya G. (author), Noorlander, Cornelle W. (author), Saedy, S. (author), van Ommen, J.R. (author), Vijver, Martina G. (author), Korevaar, G. (author)Safe-and-sustainable-by-design (SSbD) is a concept that takes a systems approach by integrating safety, sustainability, and functionality throughout a product’s the life cycle. This paper proposes a framework based on a prospective life cycle assessment for early safety and sustainability assessment. The framework’s purpose is to identify...journal article 2022
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Wu, K. (author), Galli, Federico (author), de Tommaso, Jacopo (author), Patience, Gregory S. (author), van Ommen, J.R. (author)Pressure and temperature are the most important state variables for monitoring physicochemical processes to detect deviations that might lead to explosions and to verify levels, flow rate, and solids/gas hold-up. Pressure fluctuations in multi-phase systems identify regime changes and flow anomalies. Pressure signals are the first indicator...journal article 2022
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Zhang, F. (author), La Zara, D. (author), Sun, F. (author), Quayle, Michael J. (author), Petersson, Gunilla (author), Folestad, Staffan (author), van Ommen, J.R. (author)Fluidization of cohesive pharmaceutical powders is difficult to achieve and typically requires the introduction of external forces. This study investigates the fluidization of the fine inhalation grade of lactose powders (size range from 0.1-20 μm) that are specifically developed for dry powder inhalation (DPI) applications. The fluidization...journal article 2021
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Sewalt, E.J.G. (author), Zhang, F. (author), van Steijn, V. (author), van Ommen, J.R. (author), Meesters, G.M.H. (author)Sticking of particles has a tremendous impact on powder-processing industries, especially for hygroscopic amorphous powders. A wide variety of experimental methods has been developed to measure at what combinations of temperature and moisture content material becomes sticky. This review describes, for each method, how so-called stickiness...journal article 2021
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La Zara, D. (author), Zhang, F. (author), Sun, F. (author), Bailey, Maximilian R. (author), Quayle, Michael J. (author), Petersson, Gunilla (author), Folestad, Staffan (author), van Ommen, J.R. (author)The wettability of pharmaceuticals is a key physical property which influences their dissolution rate, dispersibility, flowability and solid-state stability. Here, we provide a platform of surface nanoengineering methods capable of tuning the wettability of drug powders from high hydrophilicity to superhydrophobicity with drug loadings up to...journal article 2021
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La Zara, D. (author), Sun, F. (author), Zhang, F. (author), Franek, Frans (author), Balogh Sivars, Kinga (author), Horndahl, Jenny (author), Bates, Stephanie (author), Brännström, Marie (author), van Ommen, J.R. (author)Ideal controlled pulmonary drug delivery systems provide sustained release by retarding lung clearance mechanisms and efficient lung deposition to maintain therapeutic concentrations over prolonged time. Here, we use atomic layer deposition (ALD) to simultaneously tailor the release and aerosolization properties of inhaled drug particles...journal article 2021
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Mahtabani, Amirhossein (author), La Zara, D. (author), Anyszka, Rafał (author), He, Xiaozhen (author), Paajanen, Mika (author), van Ommen, J.R. (author), Dierkes, Wilma (author), Blume, Anke (author)Functionalized nanoparticles have various applications, for which grafting of a chemical moiety onto the surface to induce/improve certain properties is needed. When incorporated in polymeric matrices, for instance, the modified nanoparticles can alter the interfacial characteristics leading to improvements ofthe macroscopic properties of the...journal article 2021
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van Gelder, P.H.A.J.M. (author), Taebi, B. (author), van Ommen, J.R. (author), van de Poel, I.R. (author), Asveld, L. (author), Balkenende, A.R. (author), Hollmann, F. (author), van Kampen, E. (author), Krebbers, R.J. (author), de Lange, J. (author), Terwel, K.C. (author), Visser, Eelco (author)In this paper, we provide an overview of how Safe-by-Design is conceived and applied in practice in a large number of engineering disciplines. We discuss the differences, commonalities, and possibilities for mutual learning found in those practices and identify several ways of putting those disciplinary outlooks in perspective. The considered...journal article 2021
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Forner-Escrig, Josep (author), Navarrete, Nuria (author), Palma, Roberto (author), La Zara, D. (author), Goulas, A. (author), Valdesueiro, David (author), van Ommen, J.R. (author), Hernández, Leonor (author), Mondragón, Rosa (author)Nanoencapsulated phase change materials (nePCMs) are nowadays under research for thermal energy storage purposes. NePCMs are composed of a phase change core surrounded by a shell that confines the core when molten. One of the main concerns of nePCMs when subjected to thermal processes is the mechanical failure of the passivation shell...journal article 2021
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Yu, Cunming (author), Sasic, Srdjan (author), Liu, Kai (author), Salameh, S. (author), Ras, Robin H.A. (author), van Ommen, J.R. (author)Nature-inspired self-cleaning surfaces have attracted considerable attention from both fundamental research and practical applications. This review adopts a chemical-engineering point of view and focuses on mechanisms, modelling, and manufacturing (M3) of nature-inspired self-cleaning surfaces. We will introduce six nature-inspired self...journal article 2020