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The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis

Moerman, A. M. (author), Korteland, S. (author), Dilba, K. (author), van Gaalen, K. (author), Poot, D. H.J. (author), van Der Lugt, A. (author), Verhagen, H. J.M. (author), Wentzel, J. J. (author), van Der Steen, A. F.W. (author), Gijsen, F.J.H. (author), Van der Heiden, K. (author)

The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two...

journal article 2022

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Altered tract-specific white matter microstructure is related to poorer cognitive performance. The Rotterdam Study

Cremers, LGM (author), de Groot, M (author), Hofman, A (author), Krestin, GP (author), van der Lugt, A. (author), Niessen, W.J. (author), Vernooij, MW (author), Arfan Ikram, M. (author)

White matter microstructural integrity has been related to cognition. Yet, the potential role of specificwhite matter tracts on top of a global white matter effect remains unclear, especially when consideringspecific cognitive domains. Therefore, we determined the tract-specific effect of white matter micro-structure on global cognition and...

journal article 2016

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The Rotterdam Scan Study: Design update 2016 and main findings

Ikram, M.A. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Koudstaal, P.J. (author), Krestin, G.P. (author), Hofman, A. (author), Bos, D. (author), Vernooij, M.W. (author)

Imaging plays an essential role in research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to elucidate the causes of neurological disease by performing imaging of the brain in a prospective population-based setting. Initially, in 1995 and 1999, random...

journal article 2015

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A computer-simulation study on the effects of MRI voxel dimensions on carotid plaque lipid-core and fibrous cap segmentation and stress modeling

Nieuwstadt, H.A. (author), Kassar, Z.A.M. (author), Van der Lugt, A. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)

Background The benefits of a decreased slice thickness and/or in-plane voxel size in carotid MRI for atherosclerotic plaque component quantification accuracy and biomechanical peak cap stress analysis have not yet been investigated in detail because of practical limitations. Methods In order to provide a methodology that allows such an...

journal article 2015

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Photoacoustic imaging of carotid artery atherosclerosis

Kruizinga, P. (author), Springeling, G. (author), Van Soest, G. (author), Van der Steen, A.F.W. (author), De Jong, N. (author), Robertus, J.L. (author), Van der Lugt, A. (author)

We introduce a method for photoacoustic imaging of the carotid artery, tailored toward detection of lipid-rich atherosclerotic lesions. A common human carotid artery was obtained at autopsy, embedded in a neck mimicking phantom and imaged with a multimodality imaging system using interstitial illumination. Light was delivered through a 1.25-mm...

journal article 2014

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Older age relates to worsening of fine motor skills: A population-based study of middle-aged and elderly persons

Hoogendam, Y.Y. (author), Van der Lijn, F. (author), Vernooij, M.W. (author), Hofman, A. (author), Niessen, W.J. (author), Van der Lugt, A. (author), Arfan Ikram, M. (author), Van der Geest, J.N. (author)

Introduction: In a population-based study of 1,912 community-dwelling persons of 45 years and older, we investigated the relation between age and fine motor skills using the Archimedes spiral-drawing test. Also, we studied the effect of brain volume on fine motor skills. Methods: Participants were required to trace a template of a spiral on an...

journal article 2014

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Atherosclerotic plaque fibrous cap assessment under an oblique scan plane orientation in carotid MRI

Nieuwstadt, H.A. (author), Van der Lugt, A. (author), Kassar, Z.A.M. (author), Breeuwer, M. (author), Van der Steen, A.F.W. (author), Gijsen, F.J.H. (author)

Carotid magnetic resonance imaging (MRI) is used to noninvasively assess atherosclerotic plaque fibrous cap (FC) status, which is closely related to ischemic stroke. Acquiring anisotropic voxels improves in-plane visualization, however, an oblique scan plane orientation could then obscure a FC (i.e., contrast below the noise level) and thus...

journal article 2014

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Development and Validation of Intracranial Thrombus Segmentation on CT Angiography in Patients with Acute Ischemic Stroke

Santos, E.M.M. (author), Marquering, H.A. (author), Berkhemer, O.A. (author), Van Zwam, W.H. (author), Van der Lugt, A. (author), Majoie, C.B. (author), Niessen, W.J. (author)

Background and Purpose: Thrombus characterization is increasingly considered important in predicting treatment success for patients with acute ischemic stroke. The lack of intensity contrast between thrombus and surrounding tissue in CT images makes manual delineation a difficult and time consuming task. Our aim was to develop an automated...

journal article 2014

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Atherosclerotic Plaque Component Segmentation in Combined Carotid MRI and CTA Data Incorporating Class Label Uncertainty

Van Engelen, A. (author), Niessen, W.J. (author), Klein, S. (author), Groen, H.C. (author), Verhagen, H.J.M. (author), Wentzel, J.J. (author), Van der Lugt, A. (author), De Bruijne, M. (author)

Atherosclerotic plaque composition can indicate plaque vulnerability. We segment atherosclerotic plaque components from the carotid artery on a combination of in vivo MRI and CT-angiography (CTA) data using supervised voxelwise classification. In contrast to previous studies the ground truth for training is directly obtained from 3D registration...

journal article 2014

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Carotid atherosclerotic plaque progression and change in plaque composition over time: A 5-year follow-up study with serial CT angiography

van Gils, MJ (author), Vukadinovic, D (author), Dippel, DWJ (author), Niessen, W.J. (author), van der Lugt, A. (author)

journal article 2012

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Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant chemotherapy

Koppelmans, V. (author), De Ruijter, M.B. (author), Van der Lijn, F. (author), Boogerd, W. (author), Seynaeve, C. (author), Van der Lugt, A. (author), Vrooman, H. (author), Niessen, W.J. (author), Breteler, M.M.B. (author), Schagen, S.B. (author)

A limited number of studies have associated adjuvant chemotherapy with structural brain changes. These studies had small sample sizes and were conducted shortly after cessation of chemotherapy. Results of these studies indicate local gray matter volume decrease and an increase in white matter lesions. Up till now, it is unclear if non-CNS...

journal article 2011

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The Rotterdam Scan Study: Design and update up to 2012

Ikram, M.A. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Krestin, G.P. (author), Koudstaal, P.J. (author), Hofman, A. (author), Breteler, M.M.B. (author), Vernooij, M.W. (author)

Neuroimaging plays an important role in etiologic research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to unravel causes of neurological disease by performing neuroimaging in a population-based longitudinal setting. In 1995 and 1999 random subsets of the...

journal article 2011

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Estimating 3D lumen centerlines of carotid arteries in free-hand acquisition ultrasound

Carvalho, D.D.B. (author), Klein, S. (author), Akkus, Z. (author), Ten Kate, G.L. (author), Schinkel, A.F.L. (author), Bosch, J.G. (author), Van der Lugt, A. (author), Niessen, W.J. (author)

Purpose The purpose of this paper is to present a methodology to estimate the carotid artery lumen centerlines in ultrasound (US) images obtained in a free-hand examination. Challenging aspects here are speckle noise in US images, artifacts, and the lack of contrast in the direction orthogonal to the US beam direction. Method An algorithm based...

journal article 2011

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Effects of intima stiffness and plaque morphology on peak cap stress

Akyildiz, A.C. (author), Speelman, L. (author), Van Brummelen, H. (author), Gutiérrez, M.A. (author), Virmani, R. (author), Van der Lugt, A. (author), Van der Steen, A.F.W. (author), Wentzel, J.J. (author), Gijsen, F.J.H. (author)

Background: Rupture of the cap of a vulnerable plaque present in a coronary vessel may cause myocardial infarction and death. Cap rupture occurs when the peak cap stress exceeds the cap strength. The mechanical stress within a cap depends on the plaque morphology and the material characteristics of the plaque components. A parametric study was...

journal article 2011

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Incidence, treatment, and case-fatality of non-traumatic subarachnoid haemorrhage in the Netherlands

Risselada, R. (author), De Vries, L.M. (author), Dippel, D.W.J. (author), Van Kooten, F. (author), Van der Lugt, A. (author), Niessen, W.J. (author), Firouzian, A. (author), Stricker, B.H.C. (author), Sturkenboom, M.C.J.M. (author)

Background Non-traumatic subarachnoid haemorrhage (SAH) is a devastating disorder and in the majority of cases it is caused by rupture of an intracranial aneurysm. No actual data are available on the incidence of non-traumatic SAH and aneursymal SAH (aSAH) in the Netherlands and little is known about treatment patterns of aSAH. Our purpose was...

journal article 2011

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Region based level set segmentation of the outer wall of the carotid bifurcation in CTA

Vukadinovic, D. (author), Van Walsum, T. (author), Manniesing, R. (author), Rozie, S. (author), Van der Lugt, A. (author), Niessen, W.J. (author)

This paper presents a level set based method for segmenting the outer vessel wall and plaque components of the carotid artery in CTA. The method employs a GentleBoost classification framework that classifies pixels as calcified region or not, and inside or outside the vessel wall. The combined result of both classifications is used to construct...

conference paper 2011

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Multispectral MRI centerline tracking in carotid arteries

Tang, H. (author), Van Walsum, T. (author), Van Onkelen, R.S. (author), Klein, S. (author), Hameeteman, R. (author), Schaap, M. (author), Van den Bouwhuijsen, Q. (author), Witteman, J.C.M. (author), Van der Lugt, A. (author), Van Vliet, L.J. (author), Niessen, W.J. (author)

We propose a minimum cost path approach to track the centerlines of the internal and external carotid arteries in multispectral MR data. User interaction is limited to the annotation of three seed points. The cost image is based on both a measure of vessel medialness and lumen intensity similarity in two MRA image sequences: Black Blood MRA and...

conference paper 2011

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Effects of intima stiffness and plaque morphology

Akyildiz, A.C. (author), Speelman, L (author), van Brummelen, EH (author), Gutierrez De La Merced, M.A. (author), Virmani, R (author), van der Lugt, A. (author), van der Steen, AFW (author), Wentzel, JJ (author), Gijsen, FJH (author)

journal article 2011

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Statistical analysis of minimum cost path based structural brain connectivity

De Boer, R. (author), Schaap, M. (author), Van der Lijn, F. (author), Vrooman, H.A. (author), De Groot, M. (author), Van der Lugt, A. (author), Ikram, M.A. (author), Vernooij, M.W. (author), Breteler, M.M.B. (author), Niessen, W.J. (author)

Diffusion MRI can be used to study the structural connectivity within the brain. Brain connectivity is often represented by a binary network whose topology can be studied using graph theory. We present a framework for the construction of weighted structural brain networks, containing information about connectivity, which can be effectively...

journal article 2010

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Intracranial aneurysm segmentation in 3D CT angiography: Method and quantitative validation

Firouzian, A. (author), Manniesing, R. (author), Flach, Z.H. (author), Risselada, R. (author), Van Kooten, F. (author), Sturkenboom, M.C.J.M. (author), Van der Lugt, A. (author), Niessen, W.J. (author)

conference paper 2010