Searched for: author%3A%22Vastenhouw%2C+B.%22
(1 - 12 of 12)
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Chen, Y. (author), Goorden, M.C. (author), Vastenhouw, B. (author), Beekman, F.J. (author)
Brain perfusion SPECT can be used in the diagnosis of various neurologic or psychiatric disorders, e.g. stroke, epilepsy, dementia and posttraumatic stress disorder. As traditional SPECT provides limited resolution and sensitivity, we recently proposed a high resolution focusing multi-pinhole clinical SPECT scanner dubbed G-SPECT-I (Beekman...
journal article 2020
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Chen, Y. (author), Vastenhouw, B. (author), Wu, C. (author), Goorden, M.C. (author), Beekman, F.J. (author)
SPECT can be used to image dopamine transporter (DaT) availability in the human striatum, e.g. for diagnosis of Parkinson's disease (PD). As traditional SPECT provides limited resolution and sensitivity, we proposed a full ring focusing multi-pinhole SPECT system (G-SPECT-I (Beekman 2015 Eur. J. Nucl. Med. Mol. Imaging 42 S209)) which...
journal article 2018
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Branderhorst, W. (author), Vastenhouw, B. (author), Van der Have, F. (author), Blezer, E.L.A. (author), Bleeker, W.K. (author), Beekman, F.J. (author)
Purpose: Small-animal single photon emission computed tomography (SPECT) with focused multi-pinhole collimation geometries allows scanning modes in which large amounts of photons can be collected from specific volumes of interest. Here we present new tools that improve targeted imaging of specific organs and tumours, and validate the effects of...
journal article 2010
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Wu, C. (author), Van der Have, F. (author), Vastenhouw, B. (author), Dierckx, R.A.J.O. (author), Paans, A.M.J. (author), Beekman, F.J. (author)
Purpose: In pinhole SPECT, attenuation of the photon flux on trajectories between source and pinholes affects quantitative accuracy of reconstructed images. Previously we introduced iterative methods that compensate for image degrading effects of detector and pinhole blurring, pinhole sensitivity and scatter for multi-pinhole SPECT. The aim of...
journal article 2010
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Branderhorst, W. (author), Vastenhouw, B. (author), Beekman, F.J. (author)
Single photon emission computed tomography (SPECT) and positron emission tomography (PET) visualize distributions of radioactive tracer molecules in vivo. These distributions can be calculated from projection images with iterative image reconstruction algorithms. In each iteration an update of the image is calculated after comparing a set of...
journal article 2010
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Beekman, F.J. (author), Vastenhouw, B. (author), Van der Wilt, G. (author), Vervloet, M. (author), Visscher, R. (author), Booij, J. (author), Gerrits, M. (author), Ji, C. (author), Ramakers, R. (author), Van der Have, F. (author)
With the steadily improving resolution of novel small-animal single photon emission computed tomography (SPECT) and positron emission tomography devices, highly detailed phantoms are required for testing and optimizing these systems. We present a three-dimensional (3-D) digital and physical phantom pair to represent, e.g., cerebral blood flow,...
journal article 2009
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Baiker, M. (author), Vastenhouw, B. (author), Branderhorst, W. (author), Reiber, J.H.C. (author), Beekman, F. (author), Lelieveldt, B.P.F. (author)
Highly focused Micro-SPECT scanners enable the acquisition of functional small animal data with very high-resolution. To acquire a maximum of emitted photons from a specific structure of interest and at the same time minimize the required acquisition time, typically only a small subvolume of the animal is scanned that contains the organs of...
conference paper 2009
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Van der Have, F. (author), Vastenhouw, B. (author), Ramakers, R.M. (author), Branderhorst, W. (author), Krah, J.O. (author), Ji, C. (author), Staelens, S.G. (author), Beekman, F.J. (author)
We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of murine organs down to resolutions of less than half a millimeter and high-resolution total-body imaging. Methods: The U-SPECT-II is based on a triangular stationary detector set-up, an XYZ stage that moves the animal during scanning, and interchangeable cylindric...
journal article 2009
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Baiker, M. (author), Vastenhouw, B. (author), Branderhorst, S.W. (author), Reiber, J.H.C. (author), Beekman, F.J. (author), Lelieveld, B.P.F. (author)
Highly focused Micro-SPECT scanners enable the acquisition of functional small animal data with very high-resolution. To acquire a maximum of emitted photons from a specific structure of interest and at the same time minimize the required acquisition time, typically only a small subvolume of the animal is scanned that contains the organs of...
conference paper 2009
document
Wu, C. (author), Vastenhouw, B. (author), Van der Have, F. (author), Dierckx, R.A. (author), Beekman, F.J. (author)
SPECT imaging with low dose or short acquisition time can lead to very noisy reconstructed images. With the USPECT-II system we study the effect of low-count scans, and 3D Gaussian blurring to suppress statistical errors. Three different groups of short-time cardiac rat scans were derived from a longtime scan. Images were reconstructed and then...
conference paper 2008
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Van der Have, F. (author), Vastenhouw, B. (author), Rentmeester, M. (author), Beekman, F.J. (author)
For multipinhole single-photon emission computed tomography (SPECT), iterative reconstruction algorithms are preferred over analytical methods, because of the often complex multipinhole geometries and the ability of iterative algorithms to compensate for effects like spatially variant sensitivity and resolution. Ideally, such compensation...
journal article 2008
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Beekman, F.J. (author), Van der Have, F. (author), Vastenhouw, B. (author), Branderhorst, W.J. (author), Van der Linden, A. (author), Smidt, M.P. (author)
We demonstrate new technologies for SPECT imaging with unsurpassed resolution in mice and rats. Results of the imaging of living animals will be shown. In addition development of detectors for next generation systems with an even higher resolution will be shown.
conference paper
Searched for: author%3A%22Vastenhouw%2C+B.%22
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