Machine learning for the prediction of pseudorealistic pediatric abdominal phantoms for radiation dose reconstruction

Purpose: Current phantoms used for the dose reconstruction of long-term childhood cancer survivors lack individualization. We design a method to predict highly individualized abdominal three-dimensional (3-D) phantoms automatically. Approach: We train machine learning (ML) models to map (2-D) patient features to 3-D organ-at-risk (OAR)...

Design and Application of Gene-pool Optimal Mixing Evolutionary Algorithms for Genetic Programming

Machine learning is impacting modern society at large, thanks to its increasing potential to effciently and effectively model complex and heterogeneous phenomena. While machine learning models can achieve very accurate predictions in many applications, they are not infallible. In some cases, machine learning models can deliver unreasonable...

Machine learning for automatic construction of pediatric abdominal phantoms for radiation dose reconstruction

The advent of Machine Learning (ML) is proving extremely beneficial in many healthcare applications. In pediatric oncology, retrospective studies that investigate the relationship between treatment and late adverse effects still rely on simple heuristics. To capture the effects of radiation treatment, treatment plans are typically simulated...

Symbolic regression and feature construction with GP-GOMEA applied to radiotherapy dose reconstruction of childhood cancer survivors

The recently introduced Gene-pool Optimal Mixing Evolutionary Algorithm for Genetic Programming (GP-GOMEA) has been shown to find much smaller solutions of equally high quality compared to other state-of-the-art GP approaches. This is an interesting aspect as small solutions better enable human interpretation. In this paper, an adaptation of...

Learning to Associate Distances with Historical Patient Data to Enable Fine-grained Studying of Late Adverse Effects of Paediatric Radiotherapy: Data, Methodology, and First Results