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Guo, P. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, J. G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)This paper presents a pitch-matched transceiver ASIC integrated with a 2-D transducer array for a wearable ultrasound device for transfontanelle ultrasonography. The ASIC combines 8-fold multiplexing, 4-channel micro-beamforming (μ BF) and sub-array-level digitization to achieve a 128-fold channel-count reduction. The μ BF is based on passive...conference paper 2023
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Wei, Luxi (author), Wahyulaksana, G. (author), Boni, Enrico (author), Noothout, E.C. (author), Duncker, Dirk J. (author), Tortoli, Piero (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Vos, H.J. (author)Objective: The aim of this study was to assess the feasibility and imaging options of contrast-enhanced volumetric ultrasound kidney vasculature imaging in a porcine model using a prototype sparse spiral array. Methods: Transcutaneous freehand in vivo imaging of two healthy porcine kidneys was performed according to three protocols with...journal article 2023
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Caenen, Annette (author), Keijzer, Lana (author), Bézy, Stéphanie (author), Duchenne, Jürgen (author), Orlowska, Marta (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, Johan G. (author), Voigt, Jens Uwe (author), D’hooge, Jan (author), Vos, H.J. (author)Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple...journal article 2023
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Wahyulaksana, G. (author), Wei, Luxi (author), Voorneveld, J.D. (author), Hekkert, Maaike Te Lintel (author), Strachinaru, Mihai (author), Duncker, Dirk J. (author), de Jong, N. (author), van der Steen, A.F.W. (author), Vos, H.J. (author)Assessing the coronary circulation with contrast-enhanced echocardiography has high clinical relevance. However, it is not being routinely performed in clinical practice because the current clinical tools generally cannot provide adequate image quality. The contrast agent's visibility in the myocardium is generally poor, impaired by motion...journal article 2023
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Guo, P. (author), Fool, F. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)This article presents a low-power and small-area transceiver application-specific integrated circuit (ASIC) for 3-D trans-fontanelle ultrasonography. A novel micro-beamforming receiver architecture that employs current-mode summation and boxcar integration is used to realize delay-and-sum on an N -element sub-array using N× fewer capacitive...journal article 2023
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Wei, Luxi (author), Wahyulaksana, G. (author), Boni, Enrico (author), Noothout, E.C. (author), Tortoli, Piero (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Vos, H.J. (author)Volumetric echocardiography can potentially give a more complete picture of cardiac dynamics than its two-dimensional (2D) counterpart. Current clinical volumetric imaging probes have relatively low frame rates, and often require ECG gating to stitch together an entire volume. This makes measuring fast dynamics of the heart as well as imaging...conference paper 2023
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Hopf, Y.M. (author), Ossenkoppele, B.W. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, C. (author), Vos, H.J. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)This work describes an ASIC design for high-frame-rate 3D intracardiac echocardiography probes. The chip is the first to combine element-level high-voltage pulsers and time-gain-compensation analog frontends as well as subarray beamformers and in-probe digitization in a pitch-matched fashion. The integration challenge is met by a shared hybrid...poster 2022
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Deurvorst, F.R. (author), Collado Lara, G. (author), Matalliotakis, A. (author), Vos, H.J. (author), de Jong, N. (author), Daeichin, V. (author), Verweij, M.D. (author)An in vivo range verification technology for proton beam cancer therapy, preferably in real-time and with submillimeter resolution, is desired to reduce the present uncertainty in dose localization. Acoustical imaging technologies exploiting possible local interactions between protons and microbubbles or nanodroplets might be an interesting...journal article 2022
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Wahyulaksana, G. (author), Wei, Luxi (author), Schoormans, Jasper (author), Voorneveld, J.D. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Vos, H.J. (author)Suppressing tissue clutter is an essential step in blood flow estimation and visualization, even when using ultrasound contrast agents. Blind source separation (BSS)-based clutter filter for high-framerate ultrasound imaging has been reported to perform better in tissue clutter suppression than the conventional frequency-based wall filter and...journal article 2022
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Simoes dos Santos, D. (author), Fool, F. (author), Mozaffarzadeh, M. (author), Shabanimotlagh, M. (author), Noothout, E.C. (author), Kim, T. (author), Rozsa, N.N.M. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author)High frame rate three-dimensional (3D) ultrasound imaging would offer excellent possibilities for the accurate assessment of carotid artery diseases. This calls for a matrix transducer with a large aperture and a vast number of elements. Such a matrix transducer should be interfaced with an application-specific integrated circuit (ASIC) for...journal article 2022
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Guo, P. (author), Chang, Z.Y. (author), Noothout, E.C. (author), Vos, H.J. (author), Bosch, Johan G. (author), de Jong, N. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author)This article presents a compact analog front-end (AFE) circuit for ultrasound receivers with linear-in-dB continuous gain control for time-gain compensation (TGC). The AFE consists of two variable-gain stages, both of which employ a novel complementary current-steering network (CCSN) as the interpolator to realize continuously variable gain....journal article 2022
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Ossenkoppele, B.W. (author), Wei, Luxi (author), Luijten, Ben (author), Vos, H.J. (author), de Jong, N. (author), Van Sloun, Ruud J.G. (author), Verweij, M.D. (author)3-D contrast enhanced ultrasound enables better visualization of inherently 3-D vascular geometries compared to an intersecting plane. Additionally, it would allow the application of motion correction techniques for all directions. Both contrast detection and motion correction work better on high-frame rate data. However high-frame rate 3-D...conference paper 2022
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Hopf, Y.M. (author), Ossenkoppele, Boudewine W. (author), Soozande, Mehdi (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, Chao (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)In this article, an application-specific integrated circuit (ASIC) for 3-D, high-frame-rate ultrasound imaging probes is presented. The design is the first to combine element-level, high-voltage (HV) transmitters and analog front-ends, subarray beamforming, and in-probe digitization in a scalable fashion for catheter-based probes. The...journal article 2022
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Guo, P. (author), Fool, F. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)The integration of 2D ultrasonic transducer arrays and pitch-matched ASICs has enabled the realization of various 3D ultrasound imaging devices in recent years [1]-[3]. As applications such as 3D intravascular ultrasonography, intra-cardiac echocardiography, and trans-fontanelle ultrasonography call for miniaturization and improved spatial...conference paper 2022
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Hopf, Y.M. (author), Ossenkoppele, B.W. (author), Soozande, M. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Chen, C. (author), Vos, H.J. (author), Bosch, J.G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)Intra-cardiac echography (ICE) probes (Fig. 32.2.1) are widely used in electrophysiology for their good procedure guidance and relatively safe application. ASICs are increasingly employed in these miniature probes to enhance signal quality and reduce the number of connections needed in mm-diameter catheters [1]-[5]. 3D visualization in real...conference paper 2022
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Hopf, Y.M. (author), Ossenkoppele, B.W. (author), Soozande, M. (author), Noothout, E.C. (author), Chang, Z.Y. (author), Vos, H.J. (author), Bosch, Johan G. (author), Verweij, M.D. (author), de Jong, N. (author), Pertijs, M.A.P. (author)In this letter, a compact high-voltage (HV) transmit circuit for dense 2-D transducer arrays used in 3-D ultrasonic imaging systems is presented. Stringent area requirements are addressed by a unipolar pulser with embedded transmit/receive switch. Combined with a capacitive HV level shifter, it forms the ultrasonic HV...journal article 2022
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Wei, Luxi (author), Boni, Enrico (author), Ramalli, Alessandro (author), Fool, F. (author), Noothout, E.C. (author), van der Steen, A.F.W. (author), Verweij, M.D. (author), Tortoli, Piero (author), de Jong, N. (author), Vos, H.J. (author)Two-dimensional (2-D) arrays offer volumetric imaging capabilities without the need for probe translation or rotation. A sparse array with elements seeded in a tapering spiral pattern enables one-to-one connection to an ultrasound machine, thus allowing flexible transmission and reception strategies. To test the concept of sparse spiral array...journal article 2022
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Simoes dos Santos, D. (author), Fool, F. (author), Kim, Taehoon (author), Noothout, E.C. (author), Rozsa, N.N.M. (author), Vos, H.J. (author), Bosch, Johan G. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), De Jona, Nico (author)Over the past decades, ultrasound imaging has made considerable progress based on the advancement of imaging systems as well as transducer technology. With the need for advanced transducer arrays with complex designs and technical requirements, there is also a need for suitable tools to characterize such transducers. However, despite the...conference paper 2022
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Soozande, Mehdi (author), Ossenkoppele, B.W. (author), Hopf, Y.M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), de Jong, N. (author), Vos, H.J. (author), Bosch, Johan G. (author)Atrial fibrillation (AF) is the most common cardiac arrhythmia and is normally treated by RF ablation. Intracardiac echography (ICE) is widely employed during RF ablation procedures to guide the electrophysiologist in navigating the ablation catheter, although only 2-D probes are currently clinically used. A 3-D ICE catheter would not only...journal article 2022
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Heymans, Sophie V. (author), Collado Lara, G. (author), Rovituso, M. (author), Vos, H.J. (author), D'hooge, Jan (author), de Jong, N. (author), Van Den Abeele, Koen (author)Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the door to ultrasound-based in vivo proton range verification. However, at body temperature and physiological pressures, perfluorobutane nanodroplets (PFB-NDs), which offer a good compromise between stability and radiation sensitivity, are not...journal article 2022