Searched for: author%3A%22Weihs%2C+Daphne%22
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document
Chen, J. (author), Weihs, Daphne (author), Vermolen, F.J. (author)
More than eighty percent of pancreatic cancer involves ductal adenocarcinoma with an abundant desmoplastic extracellular matrix surrounding the solid tumor entity. This aberrant tumor microenvironment facilitates a strong resistance of pancreatic cancer to medication. Although various therapeutic strategies have been reported to be effective...
journal article 2019
document
Chen, J. (author), Weihs, Daphne (author), Vermolen, F.J. (author)
During metastasis of cancer, cell migration plays a crucial role, which is normally accompanied by morphological evolution. To simulate cell deformation, we develop a phenomenological, computational model involving deformation of a cell as well as its nucleus. The migration of a single cell is orchestrated by a generic signal (e.g. a chemokine...
conference paper 2018
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Chen, J. (author), Weihs, Daphne (author), van Dijk, Marcel (author), Vermolen, F.J. (author)
Cell migration plays an essential role in cancer metastasis. In cancer invasion through confined spaces, cells must undergo extensive deformation, which is a capability related to their metastatic potentials. Here, we simulate the deformation of the cell and nucleus during invasion through a dense, physiological microenvironment by developing...
journal article 2018
document
Chen, J. (author), Weihs, Daphne (author), Vermolen, F.J. (author)
Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response as well as other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic tumor islets. This migration is determined by the...
journal article 2017
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