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Warmink, Kelly (author), Vinod, Prateeksha (author), Korthagen, Nicoline M. (author), Weinans, H.H. (author), Rios, Jaqueline L. (author)Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have a role in its initiation and progression. Obesity, which is...review 2023
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van Dijk, Bruce (author), Hooning van Duyvenbode, J. Fred F. (author), de Vor, Lisanne (author), Nurmohamed, F. Ruben H.A. (author), Lam, Marnix G.E.H. (author), Poot, Alex J. (author), Ramakers, R.M. (author), Koustoulidou, Sofia (author), Beekman, F.J. (author), Weinans, H.H. (author)Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies (mAbs) targeting S. aureus and provide evidence of the specificity and biodistribution of S.-aureus-targeting antibodies in a...journal article 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, H.H. (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...journal article 2023
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Warmink, K. (author), Rios, J. L. (author), van Valkengoed, D. R. (author), Vinod, P. (author), Korthagen, N. M. (author), Weinans, H.H. (author)Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model. Methods: Wistar-Han rats (n = 24) were fed a chow, a high-fat (HF) diet, or a high-fat/high-sucrose...journal article 2023
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Cecotto, Leonardo (author), Stapels, Daphne A.C. (author), van Kessel, Kok P.M. (author), Croes, Michiel (author), Lourens, Zeldali (author), Vogely, H. Charles (author), van der Wal, Bart C.H. (author), van Strijp, Jos A.G. (author), Weinans, H.H. (author), Amin Yavari, Saber (author)Background: Despite the extensive use of silver ions or nanoparticles in research related to preventing implant-associated infections (IAI), their use in clinical practice has been debated. This is because the strong antibacterial properties of silver are counterbalanced by adverse effects on host cells. One of the reasons for this may be the...journal article 2023
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Jahanmard, F. (author), Khodaei, A. (author), Flapper, Jasper (author), Dogan, O. (author), Roohi, K. (author), Taheri, P. (author), Weinans, H.H. (author), Storm, G. (author), Croes, M. (author), Mastrobattista, E. (author), Amin Yavari, S. (author)Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth because they are bioinert. Surface biofunctionalization of implants with immunomodulatory mediators is a recent approach to promote osteogenic factors that facilitate bone regeneration. Liposomes (Lip) can be used as a low-cost,...journal article 2023
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de Vor, Lisanne (author), van Dijk, Bruce (author), van Kessel, Kok (author), Kavanaugh, Jeffrey S. (author), de Haas, Carla (author), Aerts, Piet C. (author), Ramakers, R.M. (author), Beekman, F.J. (author), Weinans, H.H. (author)Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show...journal article 2022
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Nijhuis, Wouter (author), Verhoef, Marjolein (author), van Bergen, Christiaan (author), Weinans, H.H. (author), Sakkers, Ralph (author)Fractures in patients with osteogenesis imperfecta (OI) are caused by a decreased strength of bone due to a decreased quality and quantity of bone matrix and architecture. Mutations in the collagen type 1 encoding genes cause the altered formation of collagen type I, one of the principal building blocks of bone tissue. Due to the complexity...journal article 2022
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van Erp, Joost H.J. (author), Schlösser, Tom P.C. (author), Baijense, Ariënne W. (author), Snijders, Thom E. (author), Stevenson, Rob (author), Gielis, Willem Paul (author), Castelein, René M. (author), Weinans, H.H. (author), de Gast, Arthur (author)Femoral component orientation plays a key role in implant stability and therefore the success rate of total hip arthroplasty. To date, this topic has been studied using various definitions and a variety of imaging modalities and protocols. The aim of this study is a proof of concept that a new algorithm can be used to describe the femoral...journal article 2022
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Willemsen, Koen (author), Tryfonidou, Marianna A. (author), Sakkers, Ralph J.B. (author), Castelein, René M. (author), Beukers, Martijn (author), Seevinck, Peter R. (author), Weinans, H.H. (author), van der Wal, Bart C.H. (author), Meij, Björn P. (author)The concept of a novel patient-specific 3D-printed shelf implant should be evaluated in a relevant large animal model with hip dysplasia. Therefore, three dogs with radiographic bilateral hip dysplasia and a positive subluxation test underwent unilateral acetabular augmentation with a 3D-printed dog-specific titanium implant. The...journal article 2022
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van Dijk, Bruce (author), Nurmohamed, F. Ruben H.A. (author), Hooning van Duyvenbode, J. Fred F. (author), Veltman, Ewout S. (author), Rentenaar, Rob J. (author), Weinans, H.H. (author), Vogely, H. Charles (author), van der Wal, Bart C.H. (author)Background and purpose — The long-term results of the 1-or 2-stage revision procedure and infection-free prosthesis survival in a tertiary referral center are unknown. In this retrospective observational study, the long-term results of infection control and infection-free prosthesis survival of the peri-prosthetic joint infection-related 1...journal article 2022
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Cecotto, Leonardo (author), van Kessel, Kok (author), Wolfert, Margreet A. (author), Vogely, Charles (author), van der Wal, Bart (author), Weinans, H.H. (author), van Strijp, Jos (author), Amin Yavari, S. (author)Cationic host defense peptides (HDPs) are a promising alternative to antibiotics in the fight against Staphylococcus aureus infections. In this study, we investigated the antibacterial and immunomodulatory properties of three HDPs namely IDR-1018, CATH-2, and LL-37. Although all three HDPs significantly inhibited LPS-induced activation of...journal article 2022
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Willemsen, Koen (author), Niemeyer, Menco J.S. (author), Harlianto, Netanja I. (author), Sadiqi, Said (author), Seevinck, Peter R. (author), Sakkers, Ralph J.B. (author), Weinans, H.H. (author), Van der Wal, Bart C.H. (author)BACKGROUND AND PURPOSE: The Chiari osteotomy was a regular treatment for developmental hip dysplasia before it became mostly reserved as a salvage therapy. However, the long-term survival of the Chiari osteotomy has not been systematically investigated. We investigated the survival time of the Chiari osteotomy until conversion to total hip...journal article 2022
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Warmink, Kelly (author), Siebelt, Michiel (author), Low, Philip S. (author), Riemers, Frank M. (author), Wang, Bingbing (author), Plomp, Saskia G.M. (author), Tryfonidou, Marianna A. (author), van Weeren, P. René (author), Weinans, H.H. (author), Korthagen, Nicoline M. (author)OBJECTIVE: Folate receptor beta (FR-β) has been used as a clinical marker and target in multiple inflammatory diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA). However, the conditions under which FR-β+ macrophages arise remain unclear and could be affected by corticosteroids. Therefore, we studied FR-β expression in vitro...journal article 2022
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Willemsen, Koen (author), Magré, Joëll (author), Mol, Jeroen (author), Noordmans, Herke Jan (author), Weinans, H.H. (author), Hekman, Edsko E.G. (author), Kruyt, Moyo C. (author)For decades, the advantages of rapid prototyping for clinical use have been recognized. However, demonstrations of potential solutions to treat spinal problems that cannot be solved otherwise are scarce. In this paper, we describe the development, regulatory process, and clinical application of two types of patient specific 3D-printed devices...journal article 2022
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Willemsen, Koen (author), Tryfonidou, Marianna (author), Sakkers, Ralph (author), Castelein, René M. (author), Zadpoor, A.A. (author), Seevinck, Peter (author), Weinans, H.H. (author), Meij, Björn (author), van der Wal, Bart C.H. (author)A solution for challenging hip dysplasia surgery could be a patient-specific 3D-printed shelf implant that is positioned extra-articular and restores the dysplastic acetabular rim to normal anatomical dimensions. The anatomical correction and biomechanical stability of this concept were tested in a canine model that, like humans, also suffers...journal article 2022
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Arbabi, Saeed (author), Seevinck, Peter (author), Weinans, H.H. (author), de, Pim A. (author), Sturkenboom, Joran (author), van Hamersvelt, Robbert W. (author), Foppen, Wouter (author), Arbabi, Vahid (author)Diagnosis of ankle impingement is performed primarily by clinical examination, whereas medical imaging is used for severity staging and treatment guidance. The association of impingement symptoms with regional three-dimensional (3D) bone shape variaties visible in medical images has not been systematically explored, nor do we know the type...journal article 2022
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Current Evidence for Spinopelvic Characteristics Influencing Total Hip Arthroplasty Dislocation Riskvan der Gronde, B. A.T.D. (author), Schlösser, T. P.C. (author), van Erp, J. H.J. (author), Snijders, T. E. (author), Castelein, R. M. (author), Weinans, H.H. (author), de Gast, A. (author)BACKGROUND: Decreased pelvic mobility and pelvic retroversion may result from spinal degeneration and lead to changes in the orientation of the acetabular implant after total hip arthroplasty (THA). While multiple patient and surgery-related factors contribute to THA dislocations, there is increasing evidence that sagittal spinopelvic...review 2022
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Willemsen, K. (author), Möring, Michelle M. (author), Harlianto, Netanja I. (author), Tryfonidou, Marianna A. (author), van der Wal, Bart C.H. (author), Weinans, H.H. (author), Meij, Björn P. (author), Sakkers, Ralph J. B. (author)Hip dysplasia (HD) is common in both humans and dogs. This interconnection is because humans and dogs descended from a common ancestor and therefore have a similar anatomy at micro- and macroscopic levels. Furthermore, dogs are the animals of choice for testing new treatments for human hip dysplasia and orthopedic surgery in general. However,...review 2021
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van Erp, Joost H.J. (author), Snijders, Thom E. (author), Weinans, H.H. (author), Castelein, René M. (author), Schlösser, Tom P.C. (author), de Gast, Arthur (author)Introduction: Dislocation remains a major complication in total hip arthroplasty (THA), in which femoral component orientation is considered a key parameter. New imaging modalities and definitions on femoral component orientation have been introduced, describing orientation in different planes. This study aims to systematically review the...review 2021