Searched for: author:"Weinans, H.H."
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Kozijn, A. E. (author), Tartjiono, M. T. (author), Ravipati, S. (author), van der Ham, F. (author), Barrett, D. A. (author), Mastbergen, S.C. (author), Korthagen, N. M. (author), Lafeber, F. P.J.G. (author), Zuurmond, A. M. (author), Bobeldijk, I. (author), Weinans, H.H. (author), Stoop, R (author)
Objective: C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. Here we evaluated in a human CRP ...
journal article 2019
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Tümer, N. (author), Arbabi, V. (author), Gielis, Willem Paul (author), de Jong, Pim A. (author), Weinans, H.H. (author), Tuijthof, Gabrielle J.M. (author), Zadpoor, A.A. (author)
The bones forming the talocrural joint (TCJ) and subtalar joint (STJ) are often assumed to be bilaterally symmetric. Therefore, the contralateral limb (i.e. the fibula, tibia, calcaneus and talus) is used as a template or an intra-subject control in clinical and research practice. However, the validity of the symmetry assumption is...
journal article 2019
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Tan Timur, Ufuk (author), Caron, Marjolein (author), van den Akker, Guus (author), van der Windt, Anna (author), Visser, Jenny A. (author), van Rhijn, Lodewijk (author), Weinans, H.H. (author), Welting, Tim (author), Emans, Pieter (author), Jahr, H. (author)
During standard expansion culture (i.e., plasma osmolarity, 280 mOsm) human articular chondrocytes dedifferentiate, making them inappropriate for autologous chondrocyte implantation to treat cartilage defects. Increasing the osmolarity of culture media to physiological osmolarity levels of cartilage (i.e., 380 mOsm), increases collagen type...
journal article 2019
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Eastwood, D. M. (author), Allgrove, J. (author), Hvid, I. (author), Weinans, H.H. (author), Bank, R. A. (author), Sakkers, R. J. (author)
The majority of patients with osteogenesis imperfecta (OI) have mutations in the COL1A1 or COL1A2 gene, which has consequences for the composition of the bone matrix and bone architecture. The mutations result in overmodified collagen molecules, thinner collagen fibres and hypermineralization of bone tissue at a bone matrix level. Trabecular...
journal article 2019
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Snijders, Thom E. (author), Schlösser, Tom P.C. (author), van Gaalen, Steven M. (author), Castelein, Rene M. (author), Weinans, H.H. (author), de Gast, Arthur (author)
Objective: To determine the comparability among 10 radiographic anteversion methods for acetabular cup orientation in total hip arthroplasty (THA) found in the literature and the “gold” standard of assessing the anteversion with CT. Methods: This is a retrospective study that blindly compares 10 different conventional radiographic anteversion...
journal article 2019
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Pouran, B. (author), Moshtagh, Parisa R. (author), Arbabi, V. (author), Snabel, Jessica (author), Stoop, Reinout (author), Ruberti, Jeffrey (author), Malda, Jos (author), Zadpoor, A.A. (author), Weinans, H.H. (author)
An important aspect in cartilage ageing is accumulation of advanced glycation end products (AGEs) after exposure to sugars. Advanced glycation results in cross-links formation between the collagen fibrils in articular cartilage, hampering their flexibility and making cartilage more brittle. In the current study, we investigate whether...
journal article 2018
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de Visser, H.M. (author), Mastbergen, S.C. (author), Ravipati, S. (author), Welsing, P. M.J. (author), Pinto, F.C. (author), Lafeber, F.P.J.G. (author), Chapman, V. (author), Barrett, D. A. (author), Weinans, H.H. (author)
Objective Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally...
journal article 2018
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de Visser, H.M. (author), Korthagen, NM (author), Müller, C (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, H.H. (author)
Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...
journal article 2018
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Ahmadi, S.M. (author), Hedayati, R. (author), Li, Y (author), Lietaert, K. (author), Tümer, N. (author), Fatemi, A. (author), Rans, C.D. (author), Pouran, B. (author), Weinans, H.H. (author), Zadpoor, A.A. (author)
Additive manufacturing (AM) techniques enable fabrication of bone-mimicking meta-biomaterials with unprecedented combinations of topological, mechanical, and mass transport properties. The mechanical performance of AM meta-biomaterials is a direct function of their topological design. It is, however, not clear to what extent the material type...
journal article 2018
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Kolken, H.M.A. (author), Janbaz, S. (author), Leeflang, M.A. (author), Lietaert, K. (author), Weinans, H.H. (author), Zadpoor, A.A. (author)
Rationally designed meta-biomaterials present unprecedented combinations of mechanical, mass transport, and biological properties favorable for tissue regeneration. Here we introduce hybrid meta-biomaterials with rationally-distributed values of negative (auxetic) and positive Poisson’s ratios, and use them to design meta-implants that unlike...
journal article 2018
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Croes, M. (author), de Visser, H. (author), Meij, B. P. (author), Lietart, K. (author), van der Wal, B. C.H. (author), Vogely, H.C. (author), Fluit, A.C. (author), Boel, C.H.E. (author), Alblas, J (author), Weinans, H.H. (author), Amin Yavari, S. (author)
A model is needed to study the effectiveness of different anti-bacterial coatings on complex metal implants in a bone environment. This article shares data on the design of porous titanium implants for intramedullary implantation in the proximal rat tibia. The implant length, diameter and porosity were optimized after testing on cadaveric...
journal article 2018
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Koolen, Marianne K.E. (author), Pouran, B. (author), Oner, Fetullah C. (author), Zadpoor, A.A. (author), van der Jagt, Olav P. (author), Weinans, H.H. (author)
Bone substitutes are frequently used in clinical practice but often exhibit limited osteoinductivity. We hypothesized that unfocused shockwaves enhance the osteoinductivity of bone substitutes and improve osteointegration and angiogenesis. Three different bone substitutes, namely porous tricalcium phosphate, porous hydroxyapatite and porous...
journal article 2018
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Mirzaali Mazandarani, M. (author), Van Dongen, I. C.P. (author), Tümer, N. (author), Weinans, H.H. (author), Amin Yavari, S. (author), Zadpoor, A.A. (author)
Nanopillar arrays that are bactericidal but not cytotoxic against the host cells could be used in implantable medical devices to prevent implant-associated infections. It is, however, unclear what heights, widths, interspacing, and shape should be used for the nanopillars to achieve the desired antibacterial effects while not hampering the...
journal article 2018
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Kuperus, J.S. (author), Smit, E.J.M. (author), Pouran, B. (author), van Hamersvelt, R.W. (author), van Stralen, Marijn (author), Seevinck, PR (author), Buckens, C.F. (author), Bleys, Ronald L.A.W. (author), Weinans, H.H. (author), Oner, F. C. (author), de Jong, P.A. (author), Verlaan, J-J (author)
Diffuse idiopathic skeletal hyperostosis (DISH) is often theorized to be an ossification of the anterior longitudinal ligament (ALL). Using computed tomography (CT) imaging and cryomacrotome sectioning, we investigated the spatial relationship between the ALL and newly formed bone in DISH to test this hypothesis. In the current study, four...
journal article 2018
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Mirahmadi, F. (author), Koolstra, J. H. (author), Fazaeli, S. (author), Lobbezoo, F. (author), van Lenthe, G. H. (author), Snabel, Jessica (author), Stoop, R (author), Arbabi, V. (author), Weinans, H.H. (author), Everts, V (author)
Objective: Aging can cause an increase in the stiffness of hyaline cartilage as a consequence of increased protein crosslinks. By induction of crosslinking, a reduction in the diffusion of solutions into the hyaline cartilage has been observed. However, there is a lack of knowledge about the effects of aging on the biophysical and biochemical...
journal article 2018
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Rahnamay Moshtagh, P. (author), Korthagen, NM (author), Plomp, S.G. (author), Pouran, B. (author), Castelein, Rene M. (author), Zadpoor, A.A. (author), Weinans, H.H. (author)
This study aims to investigate the earliest alterations of bone and cartilage tissues as a result of different exercise protocols in the knee joint of Wistar rats. We hypothesize that pretraining to a continuous intense running protocol would protect the animals from cartilage degeneration. Three groups of animals were used: (i) an adaptive ...
journal article 2018
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Kamperman, T. (author), Henke, S. (author), Zoetebier, B. (author), Ruiterkamp, N. (author), Wang, R. (author), Pouran, B. (author), Weinans, H.H. (author), Karperien, M. (author), Leijten, J (author)
In situ gelation of water-in-oil polymer emulsions is a key method to produce hydrogel particles. Although this approach is in principle ideal for encapsulating bioactive components such as cells, the oil phase can interfere with straightforward presentation of crosslinker molecules. Several approaches have been developed to induce in-emulsion...
journal article 2017
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Bakhshandeh, S. (author), Gorgin Karaji, Z. (author), Lietaert, K. (author), Fluit, A.C. (author), Boel, C.H.E. (author), Vogely, H.C. (author), Vermonden, T (author), Hennink, W. E. (author), Weinans, H.H. (author), Zadpoor, A.A. (author), Amin Yavari, S. (author)
Implant-associated infections are notoriously difficult to treat and may even result in amputation and death. The first few days after surgery are the most critical time to prevent those infections, preferably through full eradication of the micro-organisms entering the body perioperatively. That is particularly important for patients with a...
journal article 2017
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Bobbert, F.S.L. (author), Lietaert, K. (author), Eftekhari, A.A. (author), Pouran, B. (author), Ahmadi, S.M. (author), Weinans, H.H. (author), Zadpoor, A.A. (author)
Porous biomaterials that simultaneously mimic the topological, mechanical, and mass transport properties of bone are in great demand but are rarely found in the literature. In this study, we rationally designed and additively manufactured (AM) porous metallic biomaterials based on four different types of triply periodic minimal surfaces (TPMS)...
journal article 2017
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de Visser, H.M. (author), Weinans, H.H. (author), Coeleveld, K. (author), van Rijen, M.H.P. (author), Lafeber, F.P.J.G. (author), Mastbergen, S.C. (author)
Several experimental models of osteoarthritis in rats are used to study the pathophysiology of osteoarthritis. Many mechanically induced models have the limitation that permanent joint instability is induced by, for example, ligament transection or meniscal damage. This permanent instability will counteract the potential beneficial effects of...
journal article 2016
Searched for: author:"Weinans, H.H."
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