Searched for: author%3A%22Wessels%2C+L.F.A.%22
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Lips, Esther H. (author), Michaut, Magali (author), Hoogstraat, Marlous (author), Mulder, Lennart (author), Besselink, Nicole J.M. (author), Koudijs, Marco J. (author), Cuppen, Edwin (author), Voest, Emile E. (author), Bernards, Rene (author), Nederlof, Petra M. (author), Wesseling, Jelle (author), Rodenhuis, Sjoerd (author), Wessels, L.F.A. (author)
Introduction<br/>In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance frequently occur in advanced disease. Hence there is an urgent need for targeted treatments in this breast cancer subtype. In the current study we deep sequenced DNA of tumors prior to...
journal article 2015
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Vollebergh, M.A. (author), Lips, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Wesseling, J. (author), Van de Vijver, M.J. (author), De vries, E.G.E. (author), Van Tinteren, H. (author), Jonkers, J. (author), Hauptman, M. (author), Rodenhuis, S. (author), Linn, S.C. (author)
Introduction: BRCA-mutated breast cancer cells lack the DNA-repair mechanism homologous recombination that is required for error-free DNA double-strand break (DSB) repair. Homologous recombination deficiency (HRD) may cause hypersensitivity to DNA DSB-inducing agents, such as bifunctional alkylating agents and platinum salts. HRD can be caused...
journal article 2014
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De Ronde, J.J. (author), Bonder, M.J. (author), Lips, E.H. (author), Rodenhuis, S. (author), Wessels, L.F.A. (author)
Introduction: Despite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has become clear in recent years that breast cancer is a collection of molecularly distinct diseases. With ever increasing amounts of breast cancer data becoming available, we set out to study if...
journal article 2014
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De Ronde, J.J. (author), Rigaill, G. (author), Rottenberg, S. (author), Rodenhuis, S. (author), Wessels, L.F.A. (author)
Traditional methods that aim to identify biomarkers that distinguish between two groups, like Significance Analysis of Microarrays or the t-test, perform optimally when such biomarkers show homogeneous behavior within each group and differential behavior between the groups. However, in many applications, this is not the case. Instead, a subgroup...
journal article 2013
Searched for: author%3A%22Wessels%2C+L.F.A.%22
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