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Razzi, F. (author), Dijkstra, Jouke (author), Hoogendoorn, Ayla (author), Witberg, Karen (author), Ligthart, Jurgen (author), van Esch, J.H. (author), van Steijn, V. (author), van Soest, Gijs (author), Regar, Evelyn (author)Safety and efficacy of coronary drug-eluting stents (DES) are often preclinically tested using healthy or minimally diseased swine. These generally show significant fibrotic neointima at follow-up, while in patients, incomplete healing is often observed. The aim of this study was to investigate neointima responses to DES in swine with...journal article 2023
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Lantos, Emese (author), Mótyán, Gergő (author), Frank, Éva (author), Eelkema, R. (author), van Esch, J.H. (author), Horváth, Dezső (author), Tóth, Ágota (author)In living systems adaptive regulation requires the presence of nonlinear responses in the underlying chemical networks. Positive feedbacks, for example, can lead to autocatalytic bursts that provide switches between two stable states or to oscillatory dynamics. The stereostructure stabilized by hydrogen bonds provides an enzyme its...journal article 2023
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Ghanbari, E. (author), Chen, Zian (author), Padmanabhan, P. (author), Picken, S.J. (author), van Esch, J.H. (author)We report a systematic study of the gelation behavior of nBA gelators in xylene, with odd and even n-methylene spacers between the amide groups (n = 5-10) and 17 carbons at each end. The melting temperatures (Tm0) of nBA gels are obtained from fitting our DSCN(T) model to the experimental DSC data. The found Tm0 of nBA gels is about 35 °C...journal article 2023
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Wang, Hucheng (author), Fu, Xiaoming (author), Gu, Guanyao (author), Bai, Shengyu (author), Li, Runlai (author), Zhong, Weimin (author), Guo, Xuhong (author), Eelkema, R. (author), van Esch, J.H. (author), Cao, Zhixing (author), Wang, Yiming (author)Living organisms are capable of dynamically changing their structures for adaptive functions through sophisticated reaction-diffusion processes. Here we show how active supramolecular hydrogels with programmable lifetimes and macroscopic structures can be created by relying on a simple reaction-diffusion strategy. Two hydrogel precursors ...journal article 2023
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Ghanbari, E. (author), Picken, S.J. (author), van Esch, J.H. (author)This study intends to develop design rules for binary mixture of gelators that govern their assembly behavior and subsequently explore the impact of their supramolecular assembly patterns on the gels’ rheological properties. To achieve these goals, nBA gelators with odd and even parities [n-methylene spacers between the amide groups (n = 5-10...journal article 2023
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Klemm, B. (author), Roshanasan, A. (author), Piergentili, I. (author), van Esch, J.H. (author), Eelkema, R. (author)We present an approach for detecting thiol analytes through a self-propagating amplification cycle that triggers the macroscopic degradation of a hydrogel scaffold. The amplification system consists of an allylic phosphonium salt that upon reaction with the thiol analyte releases a phosphine, which reduces a disulfide to form two thiols,...journal article 2023
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Ghanbari, E. (author), Picken, S.J. (author), van Esch, J.H. (author)We have developed an analytical method to quantitatively analyze differential scanning calorimetry (DSC) experimental data. This method provides accurate determination of thermal properties such as equilibrium melting temperature, latent heat, change of heat capacity which can be performed automatically without intervention of a DSC operator....journal article 2023
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Ghanbari, E. (author), Krishnamurthy, Aravind (author), Picken, S.J. (author), Klop, Enno A. (author), Bannenberg, L.J. (author), van Esch, J.H. (author)The crystal structure and phase behavior of bisamide gelators are investigated using differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy, X-ray diffraction (XRD), and molecular modeling, aiming at a better understanding of bisamide gel systems. A homologous series of bisamide model compounds (nBAs) was prepared...journal article 2022
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Razzi, F. (author), Lovrak, M. (author), Gruzdyte, Dovile (author), Den Hartog, Yvette (author), Duncker, Dirk J. (author), van Esch, J.H. (author), van Steijn, V. (author), van Beusekom, Heleen M.M. (author)Atherosclerotic arteries are commonly treated using drug-eluting stents (DES). However, it remains unclear whether and how the properties of atherosclerotic plaque affect drug transport in the arterial wall. A limitation of the currently used atherosclerotic animal models to study arterial drug distribution is the unpredictability of plaque...journal article 2021
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Li, G. (author), Trausel, F. (author), van der Helm, M. (author), Klemm, B. (author), Breve, T. (author), van Rossum, S.A.P. (author), Hartono, Muhamad (author), Gerlings, Harm H.P.J. (author), Lovrak, M. (author), van Esch, J.H. (author), Eelkema, R. (author)Dynamic regulation of chemical reactivity is important in many complex chemical reaction networks, such as cascade reactions and signal transduction processes. Signal responsive catalysts could play a crucial role in regulating these reaction pathways. Recently, supramolecular encapsulation was reported to regulate the activities of...journal article 2021
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Piskorz, T.K. (author), De Vries, A. H. (author), van Esch, J.H. (author)In recent years, computational methods have become an essential element of studies focusing on the self-assembly process. Although they provide unique insights, they face challenges, from which two are the most often mentioned in the literature: the temporal and spatial scale of the self-assembly. A less often mentioned issue, but not less...journal article 2021
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Lakshminarayanan, Vasudevan (author), Chockalingam, Cindhuja (author), Mendes, E. (author), van Esch, J.H. (author)Properties such as shear modulus, gelation time, structure of supramolecular hydrogels are strongly dependent on self-assembly, gelation triggering mechanism and processes used to form the gel. In our work we extend reported rheology analysis methodologies to pH-triggered supramolecular gels to understand structural insight using a model...journal article 2021
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Wang, Yiming (author), Piskorz, T.K. (author), Lovrak, M. (author), Mendes, E. (author), Guo, Xuhong (author), Eelkema, R. (author), van Esch, J.H. (author)Here, transient supramolecular hydrogels that are formed through simple aging-induced seeded self-assembly of molecular gelators are reported. In the involved molecular self-assembly system, multicomponent gelators are formed from a mixture of precursor molecules and, typically, can spontaneously self-assemble into thermodynamically more...journal article 2020
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Oldenhof, S. (author), Mytnyk, S. (author), Gil Arranja, A. (author), de Puit, M. (author), van Esch, J.H. (author)We report a flexible single-cell isolation method by imaging-assisted hydrogel formation. Our approach consists of imaging-aided selective capture of cells of interest by encasing them into a polymeric hydrogel, followed by removal of unwanted cells and subsequent release of isolated cells by enzymatic hydrogel degradation, thus offering an...journal article 2020
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Liu, Q. (author), Yuan, Z. (author), Guo, Xuhong (author), van Esch, J.H. (author)In cancer therapy, the selective targeting of cancer cells while avoiding side effects to normal cells is still full of challenges. Here, we developed dual-functionalized crescent microgels, which selectively captured and killed lung cancer cells in situ without killing other cells. Crescent microgels with the inner surface of the cavity...journal article 2020
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Wang, Yiming (author), Xu, Zhi (author), Lovrak, M. (author), le Sage, V.A.A. (author), Zhang, K. (author), Guo, Xuhong (author), Eelkema, R. (author), Mendes, E. (author), van Esch, J.H. (author)Supramolecular structures with strain-stiffening properties are ubiquitous in nature but remain rare in the lab. Herein, we report on strain-stiffening supramolecular hydrogels that are entirely produced through the self-assembly of synthetic molecular gelators. The involved gelators self-assemble into semi-flexible fibers, which thereby...journal article 2020
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Wang, Hucheng (author), Liu, Liqun (author), Bai, Shengyu (author), Guo, Xuhong (author), Eelkema, R. (author), van Esch, J.H. (author), Wang, Y. (author)The present work shows how transient supramolecular hydrogels can be formed by catalytically controlled molecular self-assembly. Catalysis formation of molecular gelators leads the self-assembly along a kinetically favored pathway, resulting in transient hydrogels. This work demonstrates an effective approach towards pathway-dependent...journal article 2020
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van Assenbergh, S.P. (author), Fokker, Marike (author), Langowski, Julian (author), van Esch, J.H. (author), Kamperman, Marleen (author), Dodou, D. (author)The adhesiveness of biological micropatterned adhesives primarily relies on their geometry (e.g., feature size, architecture) and material properties (e.g., stiffness). Over the last few decades, researchers have been mimicking the geometry and material properties of biological micropatterned adhesives. The performance of these biomimetic...journal article 2019
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Piskorz, T.K. (author), Gobbo, Cristian (author), Marrink, Siewert J. (author), De Feyter, Steven (author), De Vries, Alex H. (author), van Esch, J.H. (author)Coarse-grained molecular dynamics simulations are employed to obtain a detailed view of the formation of long-range ordered lamellar structures of physisorbed self-assembling long functionalized alkanes on graphite. During the self-assembly, two processes take place: Langmuir preferential adsorption and rearrangement on the surface. The...journal article 2019
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Liu, Q. (author), Zhao, M. (author), Mytnyk, S. (author), Klemm, B. (author), Zhang, K. (author), Wang, Y. (author), Yan, Dadong (author), Mendes, E. (author), van Esch, J.H. (author)Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self-orientation of crescent-shaped hydrogel microparticles and elucidate its mechanism. Additionally, the microparticles were used, for the first time, as...journal article 2019
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