Searched for: author%3A%22van+den+Akker%2C+E.B.%22
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Sterenborg, Rosalie B.T.M. (author), Steinbrenner, Inga (author), Li, Yong (author), Bujnis, Melissa N. (author), Naito, Tatsuhiko (author), Marouli, Eirini (author), Meima, M.E. (author), van den Akker, E.B. (author), Teumer, Alexander (author), Medici, M. (author)
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism ...
journal article 2024
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Abbassi-Daloii, Tooba (author), el Abdellaoui, Salma (author), Kan, H.E. (author), van den Akker, E.B. (author), ’t Hoen, Peter A.C. (author), Raz, Vered (author), Voortman, Lenard M. (author)
Skeletal muscles are composed of different myofiber types characterized by the expression of myosin heavy chain isoforms, which can be affected by physical activity, aging, and pathological conditions. Here, we present a step-by-step high-throughput semi-automated approach for performing myofiber type quantification of entire human or mouse...
journal article 2023
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Cordes, Martijn (author), Pike-Overzet, K. (author), van den Akker, E.B. (author), Staal, F.J.T. (author), Canté-Barrett, Kirsten (author)
Traditionally, flow cytometry has been the preferred method to characterize immune cells at the single-cell level. Flow cytometry is used in immunology mostly to measure the expression of identifying markers on the cell surface, but—with good antibodies—can also be used to assess the expression of intracellular proteins. The advent of single...
review 2023
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Kuiper, L.M. (author), Polinder-Bos, Harmke A. (author), Bizzarri, D. (author), Vojinovic, Dina (author), Vallerga, Costanza L. (author), Reinders, M.J.T. (author), Slagboom, P. Eline (author), van den Akker, E.B. (author)
Biological age captures a person's age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but here we present a large-scale study comparing them. In 2 prospective cohorts (n = 3 222), we...
journal article 2023
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Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, Marian (author), Slagboom, P. Eline (author), van den Akker, E.B. (author)
1H-NMR metabolomics data is increasingly used to track health and disease. Nightingale Health, a major supplier of 1H-NMR metabolomics, has recently updated the quantification strategy to further align with clinical standards. Such updates, however, might influence backward replicability, particularly affecting studies with repeated measures....
journal article 2023
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Frkatović-Hodžić, Azra (author), Mijakovac, Anika (author), Miškec, Karlo (author), Nostaeva, Arina (author), Sharapov, Sodbo Z. (author), Landini, Arianna (author), Haller, Toomas (author), van den Akker, E.B. (author), Sharma, Sapna (author)
Glycans are an essential structural component of immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but...
journal article 2023
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Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, M. (author), Slagboom, P. E. (author), van den Akker, E.B. (author)
Background: Missing or incomplete phenotypic information can severely deteriorate the statistical power in epidemiological studies. High-throughput quantification of small-molecules in bio-samples, i.e. ‘metabolomics’, is steadily gaining popularity, as it is highly informative for various phenotypical characteristics. Here we aim to leverage...
journal article 2022
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Maurits, Marc P. (author), Korsunsky, Ilya (author), Raychaudhuri, Soumya (author), Murphy, Shawn N. (author), Smoller, Jordan W. (author), Weiss, Scott T. (author), Huizinga, Thomas W.J. (author), Reinders, M.J.T. (author), van den Akker, E.B. (author)
Objective: To facilitate patient disease subset and risk factor identification by constructing a pipeline which is generalizable, provides easily interpretable results, and allows replication by overcoming electronic health records (EHRs) batch effects. Material and Methods: We used 1872 billing codes in EHRs of 102 880 patients from 12...
journal article 2022
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Melsen, Janine E. (author), van Ostaijen-ten Dam, Monique M. (author), van den Akker, E.B. (author), Welters, Marij J.P. (author), Heezen, Kim C. (author), Pico-Knijnenburg, Ingrid (author), Kolijn, P.M. (author), Bredius, Robbert G.M. (author), van Doorn, Remco (author)
The first successful European hematopoietic stem cell transplantation (HSCT) was performed in 1968 as treatment in a newborn with IL2RG deficiency using an HLA-identical sibling donor. Because of declining naive T and natural killer (NK) cells, and persistent human papilloma virus (HPV)-induced warts, the patient received a peripheral stem...
journal article 2022
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Bizzarri, D. (author), Reinders, M.J.T. (author), Beekman, M. (author), Slagboom, P. E. (author), van den Akker, E.B. (author)
Motivation: 1H-NMR metabolomics is rapidly becoming a standard resource in large epidemiological studies to acquire metabolic profiles in large numbers of samples in a relatively low-priced and standardized manner. Concomitantly, metabolomics-based models are increasingly developed that capture disease risk or clinical risk factors. These...
journal article 2022
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Niehues, Anna (author), Bizzarri, Daniele (author), Reinders, M.J.T. (author), Slagboom, P. Eline (author), van Gool, Alain J. (author), van den Akker, E.B. (author), 't Hoen, Peter A.C. (author)
Population-scale expression profiling studies can provide valuable insights into biological and disease-underlying mechanisms. The availability of phenotypic traits is essential for studying clinical effects. Therefore, missing, incomplete, or inaccurate phenotypic information can make analyses challenging and prevent RNA-seq or other omics...
journal article 2022
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Buergel, Thore (author), Steinfeldt, Jakob (author), Ruyoga, Greg (author), Pietzner, Maik (author), Bizzarri, Daniele (author), Vojinovic, Dina (author), Upmeier zu Belzen, Julius (author), Loock, Lukas (author), van den Akker, E.B. (author)
Risk stratification is critical for the early identification of high-risk individuals and disease prevention. Here we explored the potential of nuclear magnetic resonance (NMR) spectroscopy-derived metabolomic profiles to inform on multidisease risk beyond conventional clinical predictors for the onset of 24 common conditions, including...
journal article 2022
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Bogaards, Fatih A. (author), Gehrmann, Thies (author), Beekman, Marian (author), van den Akker, E.B. (author), van de Rest, Ondine (author), Hangelbroek, Roland W.J. (author), Noordam, Raymond (author), Mooijaart, Simon P. (author), Reinders, M.J.T. (author)
The response to lifestyle intervention studies is often heterogeneous, especially in older adults. Subtle responses that may represent a health gain for individuals are not always detected by classical health variables, stressing the need for novel biomarkers that detect intermediate changes in metabolic, inflammatory, and immunity-related...
journal article 2022
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Bizzarri, D. (author), Dollé, Martijn E. T. (author), Loef, Bette (author), van den Akker, E.B. (author), van Kerkhof, Linda W. M. (author)
Sustained night shift work is associated with various adverse health risks, including an increased risk of cardiovascular disease, type II diabetes, and susceptibility to infectious respiratory diseases. The extent of these adverse health effects, however, seems to greatly vary between night shift workers, yet the underlying reasons and the...
journal article 2022
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Cordes, Martijn (author), Canté-Barrett, Kirsten (author), van den Akker, E.B. (author), Moretti, Federico A. (author), Kiełbasa, Szymon M. (author), Vloemans, Sandra A. (author), Garcia-Perez, Laura (author), Teodosio, Cristina (author), van Dongen, Jacques J.M. (author), Pike-Overzet, K. (author), Reinders, M.J.T. (author), Staal, F.J.T. (author)
T cell development in the mouse thymus has been studied extensively, but less is known regarding T cell development in the human thymus. We used a combination of single-cell techniques and functional assays to perform deep immune profiling of human T cell development, focusing on the initial stages of prelineage commitment. We identified...
journal article 2022
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May, Christina M. (author), van den Akker, E.B. (author), Zwaan, Bas J. (author)
Developmental diet is known to exert long-term effects on adult phenotypes in many animal species as well as disease risk in humans, purportedly mediated through long-term changes in gene expression. However, there are few studies linking developmental diet to adult gene expression. Here, we use a full-factorial design to address how three...
journal article 2021
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Khatri, I. (author), Diks, Annieck M. (author), van den Akker, E.B. (author), Oosten, Liesbeth E. M. (author), Zwaginga, Jaap Jan (author), Reinders, M.J.T. (author), van Dongen, Jacques J. M. (author), Berkowska, Magdalena A. (author)
To mount an adequate immune response against pathogens, stepwise mutation and selection processes are crucial functions of the adaptive immune system. To better characterize a successful vaccination response, we performed longitudinal (days 0, 5, 7, 10, and 14 after Boostrix vaccination) analysis of the single-cell transcriptome as well as the B...
journal article 2021
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Khatri, I. (author), Berkowska, Magdalena A. (author), van den Akker, E.B. (author), Teodosio, Cristina (author), Reinders, M.J.T. (author), van Dongen, Jacques J. M. (author)
Immunoglobulin (IG) loci harbor inter-individual allelic variants in many different germline IG variable, diversity and joining genes of the IG heavy (IGH), kappa (IGK) and lambda (IGL) loci, which together form the genetic basis of the highly diverse antigen-specific B-cell receptors. These allelic variants can be shared between or be...
journal article 2021
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Khatri, Indu (author), Berkowska, Magdalena A. (author), van den Akker, E.B. (author), Teodosio, Cristina (author), Reinders, M.J.T. (author), van Dongen, Jacques J.M. (author)
journal article 2021
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Arindrarto, Wibowo (author), Borràs, Daniel M. (author), de Groen, Ruben A.L. (author), van den Berg, Redmar R. (author), Locher, Irene J. (author), van Diessen, Saskia A.M.E. (author), Valk, Peter J.M. (author), Janssen, Bart (author), van den Akker, E.B. (author)
Acute myeloid leukemia (AML) is caused by genetic aberrations that also govern the prognosis of patients and guide risk-adapted and targeted therapy. Genetic aberrations in AML are structurally diverse and currently detected by different diagnostic assays. This study sought to establish whole transcriptome RNA sequencing as single,...
journal article 2021
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