Searched for: author:"van der Steen, A.F.W."
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Langeveld, Simone A.G. (author), Beekers, Inés (author), Collado Lara, G. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Kooiman, Klazina (author)
Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the...
journal article 2021
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Zangabad, Reza Pakdaman (author), Bosch, Johan G. (author), Mastik, Frits (author), Beurskens, Robert H.S.H. (author), Henneken, Vincent A. (author), Weekamp, Johannes W. (author), van der Steen, A.F.W. (author), van Soest, Gijs (author)
Intravascular ultrasound (IVUS) is a well-established diagnostic method that provides images of the vessel wall and atherosclerotic plaques. We investigate the potential for phased-array IVUS utilizing Coded Excitation (CE) for improving the penetration depth and image signal-to-noise ratio (SNR). It is realized on a new experimental...
journal article 2021
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Keijzer, Lana B.H. (author), Caenen, A.F.M. (author), Voorneveld, J.D. (author), Strachinaru, Mihai (author), Bowen, Daniel J. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bosch, Johan G. (author), Vos, H.J. (author)
Natural and active shear wave elastography (SWE) are potential ultrasound-based techniques to non-invasively assess myocardial stiffness, which could improve current diagnosis of heart failure. This study aims to bridge the knowledge gap between both techniques and discuss their respective impacts on cardiac stiffness evaluation. We recorded...
journal article 2020
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Cecchetti, Leonardo (author), Wang, Tianshi (author), Hoogendoorn, Ayla (author), Witberg, Karen T. (author), Ligthart, Jurgen M.R. (author), Daemen, Joost (author), van Beusekom, Heleen M.M. (author), Pfeiffer, Tom (author), van der Steen, A.F.W. (author)
To quantify the impact of cardiac motion on stent length measurements with Optical Coherence Tomography (OCT) and to demonstrate in vivo OCT imaging of implanted stents, without motion artefacts. The study consists of: clinical data evaluation, simulations and in vivo tests. A comparison between OCT-measured and nominal stent lengths in 101...
journal article 2020
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Beekers, D.I. (author), Vegter, Merel (author), Lattwein, Kirby R. (author), Mastik, Frits (author), Beurskens, Robert (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)
Ultrasound insonification of microbubbles can locally increase vascular permeability to enhance drug delivery. To control and optimize the therapeutic potential, we need to better understand the underlying biological mechanisms of the drug delivery pathways. The aim of this in vitro study was to elucidate the microbubble-endothelial cell...
journal article 2020
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López-Marín, Antonio (author), Springeling, Geert (author), Beurskens, Robert (author), Van Beusekom, Heleen (author), van der Steen, A.F.W. (author), Koch, Arjun D. (author), Bouma, Brett E. (author), Huber, Robert A. (author), Van Soest, Gijs (author), Wang, Tianshi (author)
In this study, we demonstrate a 12x36 mm motorized capsule for OCT imaging of the esophagus. The capsule produces unobstructed images by using a distal reflector design, thus avoiding shadow caused by the motor wires. The motor synchronous control enables three working modes: circumferential imaging, angular sector imaging and accurate beam...
conference paper 2020
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Doug Deen, Aaron (author), Pfeiffer, Tom (author), Van Beusekom, Heleen (author), Essers, J. (author), Huber, Robert (author), van der Steen, A.F.W. (author), Van Soest, Gijs (author), Wang, Tianshi (author)
The absorption of laser pulses by tissue leads not only to the generation of acoustic waves, but also to nanometer to sub-micrometer scale displacement. After the initial expansion, a quasi-steady state is achieved in a few microseconds. Previously we introduced the concept of thermo-elastic optical coherence tomography (TE-OCT) to "visualise...
conference paper 2020
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Beekers, D.I. (author), Mastik, Frits (author), Beurskens, Robert (author), Tang, Phoei Ying (author), Vegter, Merel (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)
Ultrasound insonification of microbubbles can locally enhance drug delivery, but the microbubble–cell interaction remains poorly understood. Because intracellular calcium (Ca<sub>i</sub> <sup>2+</sup>) is a key cellular regulator, unraveling the Ca<sub>i</sub> <sup>2+</sup> fluctuations caused by an oscillating microbubble provides crucial...
journal article 2020
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Liu, Shengnan (author), Neleman, Tara (author), Hartman, Eline M.J. (author), Ligthart, Jurgen M.R. (author), Witberg, Karen T. (author), van der Steen, A.F.W. (author), Wentzel, Jolanda J. (author), Daemen, Joost (author), van Soest, Gijs (author)
Coronary calcification represents a challenge in the treatment of coronary artery disease by stent placement. It negatively affects stent expansion and has been related to future adverse cardiac events. Intravascular ultrasound (IVUS) is known for its high sensitivity in detecting coronary calcification. At present, automated quantification...
journal article 2020
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Voorneveld, J.D. (author), Saaid, H. (author), Schinkel, C.V. (author), Radeljic, Nikola (author), Lippe, Boris (author), Gijsen, F.J.H. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Claessens, T.P.T. (author), Vos, H.J. (author), Kenjeres, S. (author), Bosch, J.W. (author)
Left ventricular (LV) blood flow is an inherently complex time-varying 3-D phenomenon, where 2-D quantification often ignores the effect of out-of-plane motion. In this study, we describe high frame rate 4-D echocardiographic particle image velocimetry (echo-PIV) using a prototype matrix transesophageal transducer and a dynamic LV phantom for...
journal article 2020
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Iskander-Rizk, Sophinese (author), Kruizinga, P. (author), Beurskens, Robert (author), Springeling, Geert (author), Mastik, Frits (author), de Groot, N.M.S. (author), Knops, Paul (author), van der Steen, A.F.W. (author), van Soest, Gijs (author)
In interventional electrophysiology, catheter-based radiofrequency (RF) ablation procedures restore cardiac heart rhythm by interrupting aberrant conduction paths. Real-time feedback on lesion formation and post-treatment lesion assessment could overcome procedural challenges related to ablation of underlying structures and lesion gaps. This...
journal article 2019
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López-Marín, Antonio (author), Springeling, Geert (author), Beurskens, Robert (author), van Beusekom, Heleen (author), van der Steen, A.F.W. (author), Koch, Arjun D. (author), Bouma, Brett E. (author), Huber, Robert (author), Soest, Gijs V.A.N. (author), Wang, Tianshi (author)
We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam...
journal article 2019
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Iskander-Rizk, Sophinese (author), van der Steen, A.F.W. (author), Van Soest, Gijs (author)
Imaging guidance is paramount to procedural success in minimally invasive interventions. Catheter-based therapies are the standard of care in the treatment of many cardiac disorders, including coronary artery disease, structural heart disease and electrophysiological conditions. Many of these diseases are caused by, or effect, a change in...
review 2019
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Keijzer, L.B.H. (author), Strachinaru, Mihai (author), Bowen, Dan J. (author), Geleijnse, Marcel L. (author), van der Steen, A.F.W. (author), Bosch, Johan G. (author), de Jong, N. (author), Vos, H.J. (author)
For the quantification of myocardial function, myocardial stiffness can potentially be measured non-invasively using shear wave elastography. Clinical diagnosis requires high precision. In 10 healthy volunteers, we studied the reproducibility of the measurement of propagation speeds of shear waves induced by aortic and mitral valve closure ...
journal article 2019
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Beekers, D.I. (author), Lattwein, Kirby R. (author), Kouijzer, Joop J.P. (author), Langeveld, Simone A.G. (author), Vegter, M. (author), Beurskens, Robert (author), Mastik, F. (author), Verduyn Lunel, Rogier (author), van der Steen, A.F.W. (author), de Jong, N. (author)
Controlling microbubble-mediated drug delivery requires the underlying biological and physical mechanisms to be unraveled. To image both microbubble oscillation upon ultrasound insonification and the resulting cellular response, we developed an optical imaging system that can achieve the necessary nanosecond temporal and nanometer spatial...
journal article 2019
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Iskander-Rizk, Sophinese (author), Kruizinga, P. (author), Van Der Steen, Antonius F.W. (author), van Soest, G. (author), van der Steen, A.F.W. (author)
Catheter-based radiofrequency ablation for atrial fibrillation has long-term success in 60-70% of cases. A better assessment of lesion quality, depth, and continuity could improve the procedure’s outcome. We investigate here photoacoustic contrast between ablated and healthy atrial-wall tissue in vitro in wavelengths spanning from 410 nm to...
journal article 2018
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Beekers, D.I. (author), van Rooij, Tom (author), van der Steen, A.F.W. (author), de Jong, N. (author), Verweij, M.D. (author), Kooiman, Klazina (author)
Ultrasound contrast agents consist of gas-filled coated microbubbles that oscillate upon ultrasound insonification. Their characteristic oscillatory response provides contrast enhancement for imaging and has the potential to locally enhance drug delivery. Since microbubble response depends on the local acoustic pressure, an ultrasound...
journal article 2018
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Janjic, Jovana (author), Tan, M. (author), Daeichin, V. (author), Noothout, E.C. (author), Chen, C. (author), Chen, Z. (author), Chang, Z.Y. (author), Beurskens, Robert H.S.H. (author), van Soest, G. (author), van der Steen, A.F.W. (author), Verweij, M.D. (author), Pertijs, M.A.P. (author), de Jong, N. (author)
Intravascular ultrasound is an imaging modality used to visualize atherosclerosis from within the inner lumen of human arteries. Complex lesions like chronic total occlusions require forward-looking intravascular ultrasound (FL-IVUS), instead of the conventional side-looking geometry. Volumetric imaging can be achieved with 2D array...
journal article 2018
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Bera, D. (author), Van Den Adel, Franc (author), Radeljic-Jakic, Nikola (author), Lippe, Boris (author), Soozande, M. (author), Pertijs, M.A.P. (author), Verweij, M.D. (author), Kruizinga, P. (author), Daeichin, V. (author), Vos, H.J. (author), van der Steen, A.F.W. (author), Bosch, Johan G. (author), de Jong, N. (author)
We describe a 3-D multiline parallel beamforming scheme for real-time volumetric ultrasound imaging using a prototype matrix transesophageal echocardiography probe with diagonally diced elements and separated transmit and receive arrays. The elements in the smaller rectangular transmit array are directly wired to the ultrasound system. The...
journal article 2018
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Skachkov, Ilya (author), Luan, Ying (author), Van Tiel, Sandra T. (author), van der Steen, A.F.W. (author), de Jong, N. (author), Bernsen, Monique R. (author), Kooiman, Klazina (author)
In vivo cell tracking of therapeutic, tumor, and endothelial cells is an emerging field and a promising technique for imaging cardiovascular disease and cancer development. Site-specific labeling of endothelial cells with the MRI contrast agent superparamagnetic iron oxide (SPIO) in the absence of toxic agents is challenging. Therefore, the...
journal article 2018
Searched for: author:"van der Steen, A.F.W."
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