Searched for: author%3A%22van+der+Valk%2C+R.A.%22
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Prabudiansyah, I. (author), van der Valk, R.A. (author), Aubin-Tam, M.E. (author)
FtsH is a membrane-bound protease that plays a crucial role in proteolytic regulation of many cellular functions. It is universally conserved in bacteria and responsible for the degradation of misfolded or misassembled proteins. A recent study has determined the structure of bacterial FtsH in detergent micelles. To properly study the function...
journal article 2021
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Dias Ribeiro de Carvalho, V.I. (author), Prabudiansyah, I. (author), Kovacik, Lubomir (author), Chami, Mohamed (author), Kieffer, R.Y. (author), van der Valk, R.A. (author), De Lange, Nick (author), Engel, Andreas (author), Aubin-Tam, M.E. (author)
AAA+ proteases are degradation machines that use ATP hydrolysis to unfold protein substrates and translocate them through a central pore toward a degradation chamber. FtsH, a bacterial membrane-anchored AAA+ protease, plays a vital role in membrane protein quality control. How substrates reach the FtsH central pore is an open key question...
journal article 2020